Exploring the Potential and Advancements of Circular RNA Therapeutics DOI Creative Commons
Lei Wang, Lianqing Wang, Chunbo Dong

et al.

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

ABSTRACT Messenger RNA (mRNA) technology is revolutionizing the pharmaceutical industry owing to its superior safety profile, manufacturing capabilities, and potential applications in previously undruggable therapeutic targets. In addition linear mRNA, such as conventional self‐amplifying trans‐amplifying circular mRNA has emerged a promising candidate. Circular (circRNA) class of single‐stranded with covalently closed loop structure that offers enhanced stability compared by resisting degradation from RNases. Recent studies have revolutionized our understanding their biological functions, surpassing notion they are merely byproducts aberrant splicing events. Given remarkable success achieved cancer SARS‐CoV‐2/monkeypox virus (MPXV) vaccines, circRNA being intensively investigated for gene cell therapies. this review, we provide an overview biogenesis mechanisms vivo, along synthesis strategies vitro, while discussing translation regulation quality control processes involved production. Furthermore, explore application scenarios circRNAs.

Language: Английский

Exploring the Potential and Advancements of Circular RNA Therapeutics DOI Creative Commons
Lei Wang, Lianqing Wang, Chunbo Dong

et al.

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

ABSTRACT Messenger RNA (mRNA) technology is revolutionizing the pharmaceutical industry owing to its superior safety profile, manufacturing capabilities, and potential applications in previously undruggable therapeutic targets. In addition linear mRNA, such as conventional self‐amplifying trans‐amplifying circular mRNA has emerged a promising candidate. Circular (circRNA) class of single‐stranded with covalently closed loop structure that offers enhanced stability compared by resisting degradation from RNases. Recent studies have revolutionized our understanding their biological functions, surpassing notion they are merely byproducts aberrant splicing events. Given remarkable success achieved cancer SARS‐CoV‐2/monkeypox virus (MPXV) vaccines, circRNA being intensively investigated for gene cell therapies. this review, we provide an overview biogenesis mechanisms vivo, along synthesis strategies vitro, while discussing translation regulation quality control processes involved production. Furthermore, explore application scenarios circRNAs.

Language: Английский

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