TREM2 modulates lipid metabolism to alleviate airway inflammation in asthma: A potential therapeutic target

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142306 - 142306

Published: March 1, 2025

Language: Английский

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Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis

Science Advances, Journal Year: 2025, Volume and Issue: 11(18)

Published: May 1, 2025

Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease, characterized by excessive fibroblast activation and collagen deposition, leading to progressive pulmonary function decline limited therapeutic efficacy. Here, the inhalable, myofibroblast-targeted, pH-responsive liposomes (FL-NI) were developed for effective codelivery of nintedanib, mainstream antifibrotic drug in clinic, siIL11, small interfering RNA that silences key profibrosis cytokine IL-11. Notably, FL-NI achieved 117.8% increase delivery noninvasive inhalation 71.5% specifically protein-positive myofibroblasts while reducing nonspecific immune cell epithelial uptake 29.8 55.8%, respectively. The accurate nintedanib siIL11 into synergistic effects, effectively enhanced myofibroblast deactivation, reduced pathological deposition 50.8%, promoted tissue repair. remodeled aberrant microenvironment without inducing systemic toxicities. Therefore, this work demonstrated notable potential pluripotent strategy improving PF outcomes its promising clinical translation.

Language: Английский

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Advances in locally administered nucleic acid therapeutics

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 218 - 254

Published: March 10, 2025

Language: Английский

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Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

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“Capture and kill” circulating fibrocytes by cisplatin prodrug loaded albumin disrupt the progress of pulmonary fibrosis in mice

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113781 - 113781

Published: April 1, 2025

Language: Английский

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