Bioactive Deproteinized Bovine Bone Mineral Based on Self-assembled Albumin Nanoparticles Promoted Bone Regeneration via Activation of Wnt/β-catenin Pathway DOI Creative Commons

Yawen Zhu,

Yu-wen Wei,

Jingyi Ma

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101730 - 101730

Published: April 1, 2025

One of the major problems faced with pre-implant bone reconstruction therapy is that large defects do not heal over time. Artificial graft materials, such as deproteinized bovine mineral, are commonly used in clinics. However, lack osteoinductive capacity and risk post-implantation infections remain key limitations. Bioactive materials strong formation a high degree biocompatibility still needed. In this study, we synthesised serum albumin nanoparticles (BNP) loaded Tideglusib (TD), TD BNP were bound together by self-assembly, mixed mineral (DBBM) to form substitute material (TD-BNP@DBBM) had low cytotoxicity, promoted cell proliferation migration, induced differentiation, regulated osteogenesis. vitro, experiments suggested TD-BNP@DBBM could promote osteoblast differentiation MC3T3-E1 cells. vivo, demonstrated significantly accelerated enhanced healing rat cranial defect model. Furthermore, result link between Wnt/β-catenin pathway osteogenic effect, providing basis for subsequent investigations into mechanism regeneration biomaterials. might be promising new approach treating defects.

Language: Английский

Bioactive Deproteinized Bovine Bone Mineral Based on Self-assembled Albumin Nanoparticles Promoted Bone Regeneration via Activation of Wnt/β-catenin Pathway DOI Creative Commons

Yawen Zhu,

Yu-wen Wei,

Jingyi Ma

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101730 - 101730

Published: April 1, 2025

One of the major problems faced with pre-implant bone reconstruction therapy is that large defects do not heal over time. Artificial graft materials, such as deproteinized bovine mineral, are commonly used in clinics. However, lack osteoinductive capacity and risk post-implantation infections remain key limitations. Bioactive materials strong formation a high degree biocompatibility still needed. In this study, we synthesised serum albumin nanoparticles (BNP) loaded Tideglusib (TD), TD BNP were bound together by self-assembly, mixed mineral (DBBM) to form substitute material (TD-BNP@DBBM) had low cytotoxicity, promoted cell proliferation migration, induced differentiation, regulated osteogenesis. vitro, experiments suggested TD-BNP@DBBM could promote osteoblast differentiation MC3T3-E1 cells. vivo, demonstrated significantly accelerated enhanced healing rat cranial defect model. Furthermore, result link between Wnt/β-catenin pathway osteogenic effect, providing basis for subsequent investigations into mechanism regeneration biomaterials. might be promising new approach treating defects.

Language: Английский

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