Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Acute kidney injury (AKI) is a life-threatening condition characterized by rapid decline in the renal function, primarily caused oxidative stress, inflammation, and ferroptosis. Herein, we present selenium-doped carbon dots (Zt-SeCDs) that integrate antioxidant activity with controlled release of Zileuton, 5-lipoxygenase (ALOX5) inhibitor, under high reactive oxygen species (ROS) conditions. This nanoplatform can efficiently deliver leveraging its inherent properties to achieve targeted prevention treatment AKI. In vitro studies have confirmed Zt-SeCDs eliminate excessive ROS, prevent ferroptotic cell death, modulate inflammatory responses reducing expression key pro-inflammatory cytokines. Additionally, regulate ferroptosis through suppression ALOX5 upregulation glutathione peroxidase 4 (GPX4) expression. The significantly improves promotes regeneration damaged tissue, alleviates processes, death. Moreover, monitoring serum indicators observing pathological changes further potential preventing Notably, activate AMPK/FoxO1 signaling pathway, enhancing endogenous defenses protect tissue from damage. promising not only holds significant promise for AKI, but also aims facilitate clinical application.

Language: Английский

Metabolism and Mendelian Randomization Study on the Mechanism of Buyang Huanwu Decoction in Regulating Iron Metabolism and Improving Cerebral Ischemia-Reperfusion Injury.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120062 - 120062

Published: June 1, 2025

Language: Английский