Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 3123 - 3138
Published: Jan. 20, 2021
Exploring
a
rational
delivery
system
of
integrating
chemotherapy
with
immunotherapy
to
broaden
benefits
cancer
immunochemotherapy
is
still
under
challenge.
Herein,
we
developed
doxorubicin
(DOX)-loaded
biomimetic
hybrid
nanovesicles
(DOX@LINV)
via
fusing
artificial
liposomes
(LIPs)
tumor-derived
(TNVs)
for
combinational
immunochemotherapy.
DOX@LINV
homologous
targeting
ability
could
deliver
DOX
tumor
tissue
and
elicit
an
effective
immunogenic
cell
death
response
improve
the
immunogenicity
tumor.
Meanwhile,
preserved
antigens
endogenous
danger
signals
in
activated
dendritic
cells
induced
subsequent
antigen-specific
T
immune
response.
displayed
specific
antitumor
effect
on
murine
melanoma,
Lewis
lung
cancer,
4T1
breast
based
infiltration
effector
improvement
immunosuppressive
microenvironment.
Furthermore,
combination
checkpoint
inhibitor
amplified
efficacy
33.3%
mice
being
tumor-free.
Therefore,
LINV
promising
drug
platform
boosted
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
