ACS Nano,
Journal Year:
2020,
Volume and Issue:
15(1), P. 1627 - 1639
Published: Dec. 23, 2020
Multifunctional
nanotheranostics
are
typically
designed
by
integrating
multiple
functional
components.
This
approach
not
only
complicates
the
preparation
process
but
also
hinders
any
bioapplication
due
to
potential
toxic
effects
when
each
component
is
metabolized.
Here,
we
report
a
safe,
biodegradable,
and
tumor-specific
nanocarrier
that,
once
activated
acidic
tumor
microenvironment
(TME),
has
diagnostic
therapeutic
functions
suitable
for
theranostics.
Our
composed
of
biomineralized
manganese
carbonate
(BMC)
nanoparticles
(NPs)
that
readily
decompose
release
Mn2+
ions
CO2
gas
in
TME
its
intrinsic
pH-dependent
solubility.
permits
magnetic
resonance
ultrasound
imaging
tumors,
respectively.
These
NPs
can
be
loaded
with
anticancer
drug
doxorubicin
(DOX):
BMC-DOX
high
inhibition
both
vitro
vivo
combined
Mn2+-mediated
chemodynamic
therapy
DOX-induced
chemotherapy.
actuating
might
promising
candidate
clinical
translation.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 6293 - 6308
Published: March 30, 2022
Glioblastoma
(GBM)
is
among
the
most
treatment-resistant
solid
tumors
and
often
recurrs
after
resection.
One
of
mechanisms
through
which
GBM
escapes
various
treatment
modalities
overexpression
anti-apoptotic
Bcl-2
family
proteins
(e.g.,
Bcl-2,
Bcl-xl,
Mcl-1)
in
tumor
cells.
Small-molecule
inhibitors
such
as
ABT-263
(ABT),
can
promote
mitochondrial-mediated
cell
apoptosis
by
selectively
inhibiting
function
have
been
proven
to
be
promising
anticancer
agents
clinical
trials.
However,
therapeutic
prospects
ABT
for
are
hampered
its
limited
blood–brain
barrier
(BBB)
penetration,
dose-dependent
thrombocytopenia,
drug
resistance
driven
Mcl-1,
overexpressed
cells
further
upregulated
upon
with
ABT.
Herein,
we
reported
that
Mcl-1-specific
inhibitor
A-1210477
(A12)
act
synergistically
induce
potent
U87
MG
cells,
drug-resistant
U251
patient-derived
cancer
stem
We
designed
a
biomimetic
nanomedicine,
based
on
apolipoprotein
E
(ApoE)
peptide-decorated
red
blood
membrane
pH-sensitive
dextran
nanoparticles,
brain-targeted
delivery
A12.
The
synergistic
anti-GBM
effect
was
retained
encapsulation
nanomedicine.
Additionally,
obtained
nanomedicine
possessed
good
biocompatibility,
exhibited
efficient
BBB
could
effectively
suppress
growth
prolong
survival
time
mice
bearing
orthotopic
xenografts
without
inducing
detectable
adverse
effects.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(3), P. 1739 - 1763
Published: Jan. 23, 2023
The
outbreak
of
COVID-19
provided
a
warning
sign
for
society
worldwide:
that
is,
we
urgently
need
to
explore
effective
strategies
combating
unpredictable
viral
pandemics.
Protective
textiles
such
as
surgery
masks
have
played
an
important
role
in
the
mitigation
pandemic,
while
revealing
serious
challenges
terms
supply,
cross-infection
risk,
and
environmental
pollution.
In
this
context,
with
antivirus
functionality
attracted
increasing
attention,
many
innovative
proposals
exciting
commercial
possibilities
been
reported
over
past
three
years.
review,
illustrate
progress
textile
filtration
pandemics
summarize
recent
development
antiviral
personal
protective
purposes
by
cataloging
them
into
classes:
metal-based,
carbon-based,
polymer-based
materials.
We
focused
on
preparation
routes
emerging
textiles,
providing
forward-looking
perspective
their
opportunities
challenges,
evaluate
efficacy,
scale
up
manufacturing
processes,
expand
high-volume
applications.
Based
conclude
ideal
are
characterized
high
efficiency,
reliable
effect,
long
storage
life,
recyclability.
expected
processes
should
be
economically
feasible,
scalable,
quickly
responsive.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: Sept. 25, 2023
Nanozymes
with
inherent
enzyme-mimicking
catalytic
properties
combat
malignant
tumor
progression
via
therapy,
while
the
therapeutic
efficacy
still
needs
to
be
improved.
In
this
work,
ultrasmall
platinum
nanozymes
(nPt)
in
a
confined
domain
of
wormlike
pore
channel
gold
nanobipyramidal-mesoporous
silica
dioxide
nanocomposites,
producing
nanozyme
carriers
AP-mSi
photoenhanced
peroxidase
ability,
are
innovatively
synthesized.
Afterward,
based
on
prepared
AP-mSi,
lung-cancer
probe
(AP-HAI)
is
ingeniously
produced
by
removing
SiO2
template,
modifying
human
serum
albumin,
and
loading
atovaquone
molecules
(ATO)
as
well
IR780.
Under
NIR
light
irradiation,
inner
AuP
IR780
collaborate
for
photothermal
process,
thus
facilitating
peroxidase-like
process
H2
O2
.
Additionally,
loaded
ATO,
cell
respiration
inhibitor,
can
impair
metabolism
cause
oxygen
retention,
hence
enhancing
IR780's
photodynamic
therapy
(PDT)
effectiveness.
As
result,
PDT
nPt
nanozymes'
ability
endow
probes
high
ROS
productivity,
eliciting
antitumor
immune
responses
destroy
tissue.
Systematic
studies
reveal
that
obvious
reactive
species
(ROS)
generation
obtained
strategy
using
reducing
consumption
which
turn
enables
synergetic
therapy/immunogenic-cell-death-based
immunotherapy.
The
results
work
would
provide
theoretical
justification
practical
use
probes.
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
7, P. 100231 - 100231
Published: Jan. 23, 2024
Over
the
last
two
decades,
researchers
have
paid
more
attention
to
magnetic
nanosystems
due
their
wide
application
in
diverse
fields.
The
metal
nanomaterials'
antimicrobial
and
biocidal
properties
make
them
an
essential
nanosystem
for
biomedical
applications.
Moreover,
could
also
been
used
diagnosis
treatment
because
of
magnetic,
optical,
fluorescence
properties.
Superparamagnetic
iron
oxide
nanoparticles
(SPIONs)
quantum
dots
(QDs)
are
most
widely
prepared
by
a
simple
process.
By
surface
modification,
recently
working
on
conjugating
metals
like
silica,
copper,
gold
with
nanosystems.
This
hybridization
modifies
structural
characteristics
nanomaterials
helps
improve
efficacy
targeted
drug
gene
delivery.
various
micelles,
cubosomes,
liposomes,
polymeric
is
gaining
interest
nanometer
size
range
nontoxic,
biocompatible
nature.
they
good
injectability
higher
targeting
ability
accumulation
at
target
site
external
field.
present
article
discussed
detail
regarding
structure,
properties,
interaction
biological
system,
diagnostic
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(5), P. 2703 - 2724
Published: April 22, 2024
The
scientific
world
is
increasingly
focusing
on
rare
earth
metal
oxide
nanomaterials
due
to
their
consequential
biological
prospects,
navigated
by
breakthroughs
in
biomedical
applications.
Terbium
belongs
elements
(lanthanide
series)
and
possesses
remarkably
strong
luminescence
at
lower
energy
emission
signal
transduction
properties,
ushering
wide
applications
for
diagnostic
measurements
(i.e.,
bioimaging,
biosensors,
fluorescence
imaging,
etc.)
the
sectors.
In
addition,
theranostic
of
terbium-based
nanoparticles
further
permit
targeted
delivery
drugs
specific
site
disease.
Furthermore,
antimicrobial
properties
terbium
induced
via
reactive
oxygen
species
(ROS)
cause
oxidative
damage
cell
membrane
nuclei
living
organisms,
ion
release,
surface
charge
interaction,
thus
creating
or
exhibiting
excellent
antioxidant
characteristics.
Moreover,
recent
tissue
engineering,
wound
healing,
anticancer
activity,
etc.,
angiogenesis,
proliferation,
promotion
growth
factors,
biocompatibility,
cytotoxicity
mitigation,
anti-inflammatory
potentials,
make
this
nanoparticle
anticipate
a
future
epoch
nanomaterials.
stand
as
game
changer
realm
research,
proffering
array
possibilities,
from
revolutionary
imaging
techniques
advanced
drug
systems.
Their
unique
including
luminescence,
magnetic
characteristics,
have
redefined
boundaries
what
can
be
achieved
biomedicine.
This
review
primarily
delves
into
various
mechanisms
involved
physicochemical
article
explains
potential
with
in-depth
significant
individual
literature.
additionally
stands
first
instance
furnish
"single-platted"
comprehensive
acquaintance
shaping
healthcare
well
limitations
overcoming
strategies
that
require
exploration
before
being
trialed
clinical
settings.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: Feb. 17, 2024
Abstract
Atherosclerosis,
a
multifaceted
chronic
inflammatory
disease,
has
profound
impact
on
cardiovascular
health.
However,
the
critical
limitations
of
atherosclerosis
management
include
delayed
detection
advanced
stages,
intricate
assessment
plaque
stability,
and
absence
efficacious
therapeutic
strategies.
Nanotheranostic
based
nanotechnology
offers
novel
paradigm
for
addressing
these
challenges
by
amalgamating
imaging
capabilities
with
targeted
interventions.
Meanwhile,
iron
oxide
nanoparticles
have
emerged
as
compelling
candidates
theranostic
applications
in
due
to
their
magnetic
resonance
capability
biosafety.
This
review
delineates
current
state
prospects
nanoparticle‐based
nanotheranostics
realm
atherosclerosis,
including
pivotal
aspects
development,
pertinent
targeting
strategies
involved
disease
pathogenesis,
diagnostic
roles
nanoparticles.
Furthermore,
this
provides
comprehensive
overview
nanomedicine
approaches
employing
nanoparticles,
encompassing
chemical
therapy,
physical
stimulation
biological
therapy.
Finally,
proposes
discusses
associated
translating
innovative
into
clinically
viable
anti‐atherosclerosis
In
conclusion,
new
insights
future
theranostic,
showcasing
remarkable
potential
oxide‐based
versatile
tools
battle
against
atherosclerosis.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(19), P. 8827 - 8836
Published: April 15, 2020
Blood
proteins
adsorb
onto
the
surface
of
nanoparticles
after
intravenous
injection
to
form
a
protein
corona.
The
underlying
organization
and
binding
function
these
adsorbed
remain
unclear.
This
can
impact
how
corona
mediates
cell
tissue
interactions.
Here,
we
investigated
structural
using
an
immunoassay
approach.
We
discovered
that
only
27%
examined
are
functional
for
their
target
protein.
is
because
architecture
not
monolayer,
but
assembly
bound
each
other.
further
demonstrated
control
functionality
by
changing
in
assembly.
show
manipulation
composition
influence
interactions
with
macrophage
cells
culture.
study
provides
detailed
insights
into
on
nanomaterials
offers
new
strategy
manipulate
it
controlled
biological
system.
Nanoscale,
Journal Year:
2020,
Volume and Issue:
13(2), P. 460 - 484
Published: Dec. 10, 2020
The
extensive
research
on
liquid-phase
exfoliation
(LPE)
performed
in
the
last
10
years
has
enabled
a
low
cost
and
mass
scalable
approach
to
successful
production
of
range
solution-processed
2-dimensional
(2D)
materials
suitable
for
many
applications,
from
composites
energy
storage
printed
electronics.
However,
direct
LPE
requires
use
specific
solvents,
which
are
typically
toxic
expensive.
Dispersant-assisted
allows
us
overcome
this
problem
by
enabling
solution
processed
2D
wider
including
water.
This
is
based
inclusion
an
additive,
amphiphilic
molecule,
designed
interact
with
both
nanosheet
solvent,
stabilization
at
same
time.
method
been
extensively
used
graphene
discussed
reviews,
whilst
little
attention
given
dispersant-assisted
beyond
graphene.
Considering
increasing
number
their
potential
nanomedicine
catalysis,
review
focuses
transition
metal
dichalcogenides
(TMDs),
hexagonal
boron
nitride
(h-BN)
less
studied
materials.
We
first
provide
introduction
fundamentals
type
dispersants
that
have
graphene,
we
then
discuss
each
class
material,
providing
overview
concentration
properties
nanosheets
obtained.
Finally,
perspective
some
challenges
need
be
addressed
field
research.
