ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(47), P. 42809 - 42818
Published: Nov. 14, 2022
A
Schiff
base
bearing
two
methyl
substituents,
namely,
6,6'-((1E,1'E)-((2,2-dimethylpropane-1,3-diyl)
bis(azanylylidene))
bis(methanylylidene))
bis(2-methylphenol)
[H2AD1Me]
was
synthesized
and
characterized
through
physicochemical
spectroscopic
analyses.
Then,
the
complexed
with
Pd(II)
Ni(II)
to
form
[Pd(AD1Me)]
[Ni(AD1Me)],
respectively.
Both
metal
complexes
were
successfully
obtained
several
analyses,
viz.,
melting
point,
elemental
analysis,
molar
conductivity,
magnetic
susceptibility,
FTIR,
1H
NMR,
UV-vis,
single
crystal
X-ray
diffraction.
quantitative
analysis
of
intermolecular
interactions
in
structures
has
been
performed
using
Hirshfeld
surface
analysis.
crystallized
a
monoclinic
system
space
group
P21/c.
Additionally,
deprotonated
phenolic
oxygen
atom
(O1/O2)
azomethine
nitrogen
(N1/N2)
ligand
chelate
ions,
forming
slightly
distorted
square-planar
complex
containing
three
six-membered
rings
encircling
core
dsp2
hybridization.
The
shift
ν(C=N)
higher
frequency
FTIR
by
26-28
cm-1
indicated
that
complexation
N
established.
It
further
supported
shifting
proton
signal
or
lower
chemical
shifts
Δδ
=
0.43-1.15
ppm
NMR.
In
addition,
n-π*(C=N)
band
UV-vis
spectra
Δλ
24-40
nm
involvement
complexation.
All
compounds
showed
no
significant
antibacterial
activity
against
bacterial
strains,
Staphylococcus
aureus
subsp.
Rosenbach
(ATCC
6538),
Streptococcus
mutans
Clarke
700,610),
Proteus
vulgaris
6380),
as
percent
growth
inhibition
calculated
less
than
90%.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 23, 2023
Tuberculosis
disease
is
a
serious
threat
to
humans
and
spreading
quickly
worldwide,
therefore,
find
potent
drug,
the
synthesis
of
hydrazone
ligands
endowed
Co(II),
Ni(II),
Cu(II),
Zn(II)
metal
complexes
were
carried
out
well
characterized
by
numerous
spectral
analytical
techniques.
The
octahedral
geometry
was
confirmed
analysis.
Further,
in
vitro
antituberculosis
efficacy
compounds
(1-10)
revealed
that
(6),
(9),
(10)
have
highest
potency
control
TB
malformation
with
0.0028
±
0.0013-0.0063
0.0013
µmol/mL
MIC
value
while
complex
(0.0028
µmol/mL)
has
nearly
four
time
suppress
comparison
streptomycin
(0.0107
0.0011
µmol/mL).
antimicrobial
anti-inflammatory
evaluations
more
active
lowest
(0.0057-0.0114
IC50
(7.14
0.05
µM)
values,
correspondingly
which
are
comparable
their
respective
standard
drugs.
Furthermore,
theoretical
studies
such
as
molecular
docking,
DFT,
MESP
ADMET
employed
authenticate
HL2
ligand
(2)
its
(7-10)
zinc(II)
might
be
utilized
novel
drug
candidate
for
tuberculosis
dysfunctions.
So,
present
research
gives
new
insight
vivo
investigation
compounds.
Journal of Coordination Chemistry,
Journal Year:
2023,
Volume and Issue:
76(5-6), P. 546 - 580
Published: March 19, 2023
The
discovery
of
new
chemical
entities
having
enhanced
bioactivities
and
improved
functionalities
to
overcome
the
prevailing
antibiotic
resistance
emerging
diseases
has
evolved
as
one
most
needed
research
areas
in
pharmaceutical
field.
Intensive
been
done
on
metal-based
drugs
a
result,
metal
complexes
various
Schiff
bases
are
acknowledged
potential
area
bioinorganic
chemistry
account
their
promising
applicable
uses
several
fields
science.
base
sulfonamides
versatile
pharmacophores
forming
stable
compounds
by
coordinating
with
metals
oxidation
states.
As
therapeutic
candidates,
they
have
actively
used
many
applications
including
antifungal,
analgesic,
anti-inflammatory,
antiviral,
antitumor,
antibacterial
more.
There
worldwide
risk
drug
medical
field
pathogenic
microbes
capable
deactivating
substances.
This
review
summarizes
developments
that
taken
place
from
2008
2022
activities
derived
compounds.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(3)
Published: Jan. 17, 2024
For
further
pharmaceutical
applications,
a
novel
Schiff
base
derivative
of
aminothiazole
and
its
Co
(II),
Cu
Zn
Th
(IV)
chelates
were
designed
prepared.
this
purpose,
2‐aminothiazole
2,4‐dihydroxybenzaldehyde
have
been
coupled
before
the
complexation
reaction
with
metal
salts.
Elemental
analysis,
FT‐IR,
1HNMR,
UV–Vis
spectra,
transmission
electron
microscopy
(TEM),
X‐ray
powder
diffraction
(XRD),
molar
conductance,
magnetic
moment
measurements
used
to
determine
structural
formula
ligand
produced
chelates.
The
acquired
data
pointed
out
that
was
chelated
through
nitrogen
azo
group
deprotonated
ortho
phenolic
oxygen
atoms.
In
(II)
complex
copper
ion
two
molecules,
whereas
in
other
complexes
binds
one
molecule
only
ligand.
It
shown
by
XRD
patterns
high‐resolution
TEM
images
particles
had
uniform
distribution
across
chelates'
surfaces
nanometric
size.
Extremely,
antimicrobial
anticancer
activity
for
prepared
investigated,
which
showed
high
activity,
especially
after
formation.
Docking
studies
performed
predict
compounds'
efficacy
as
antitumor
agents
their
interaction
co‐crystal
structure
proteins
breast
cancer
cells
(PDB
ID:
3S7S)
protein
liver
2
2JW2).
experimental
results
promising
results,
compound
exhibited
greatest
(IC
50
=
12.81
μg/ml)
contra
HepG‐2
carcinoma
Mcf‐7
18.92
±
0.91
μg/ml).
Antimicrobial
against
strains
Klebsiella
pneumoniae
(
K.
),
Escherichia
coli
E.
Staphylococcus
aureus
S.
Bacillus
subtilis
(B.
subtilis),
C.
albicans
Aspergillus
niger
(A.
niger)
also
gave
very
when
it
is
compared
standard
drugs.
Journal of Coordination Chemistry,
Journal Year:
2022,
Volume and Issue:
75(3-4), P. 293 - 334
Published: Feb. 16, 2022
From
the
apocalyptic
era
of
antibiotic
resistance,
scientific
community
around
world
is
engaged
in
designing
and
developing
metal-based
compounds
to
inhibit
control
continuously
rising
microbial
infections.
Metal
based
triazole-derived
are
being
explored
for
antimicrobial
actions
potentially
applicable
provide
effective
nontoxic
drug
candidates
having
preferred
improved
pharmacological
activity.
Updating
existing
literature
supporting
such
details,
this
review
combines
chemistry,
synthetic
aspects
formation
triazole
Schiff
bases,
mechanism
bioactivity
metal
complexes
accompanied
by
assessment
biological
efficacy
including
antibacterial,
antifungal,
enzyme
inhibition
antioxidant
This
covers
bioactive
symmetrical
assymmetrical
mono
bis-Schiff
bases
synthesized
from
condensation
involving
amine
group
3-amino-1,2,4-triazole
3,5-diamino-1,2,4-triazole
with
carbonyl
several
aromatic
aldehydes
ketones
along
their
transition
which
were
characterized
physical,
spectral
chemical
properties.
In
most
studies
highlighting
biomedical
imine
functionalized
compounds,
showed
outstanding
results
comparison
free
ligands.
