Facile synthesis of bis(indol-3-yl)methane derivatives catalyzed by carboxylic acid functionalized ionic liquid at room temperature: Investigation of photophysical properties, DFT calculations and molecular docking with bovine serum albumin

Tetrahedron, Journal Year: 2024, Volume and Issue: 153, P. 133845 - 133845

Published: Jan. 23, 2024

Language: Английский

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Functionalized graphene oxide by 4-amino-3-hydroxy-1-naphthalenesulfonic acid as a heterogeneous nanocatalyst for one-pot synthesis of tetraketone and tetrahydrobenzo[b]pyran derivatives under green conditions

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(15), P. 3911 - 3922

Published: Jan. 1, 2024

4-Amino-3-hydroxy-1-naphthalenesulfonic acid-functionalized graphene oxide (GO-ANSA) was prepared and used as a highly efficient reusable solid acid carbocatalyst for synthesis of tetraketone well tetrahydrobenzo[ b ]pyran derivatives.

Language: Английский

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Immobilized Schiff base-Mn complex as a hybrid magnetic nanocatalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(10), P. 2713 - 2721

Published: Jan. 1, 2024

Fe 3 O 4 @SiO 2 @Mn-complex was successfully prepared and utilized in the synthesis of biologically active pyridopyrimidinones an aqueous medium, providing environmentally friendly conditions.

Language: Английский

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[CMMIM][BF₄] as a Sustainable Catalyst for Spirooxindoles Synthesis via One‐Pot Multicomponent Reaction: Insights into their Photophysical Properties and Theoretical Calculations

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(15)

Published: April 16, 2024

Abstract This study shows an effective approach for the synthesis of spirooxindole‐pyrans and bis‐spirooxindole‐pyrans derivatives using 5 mol % [CMMIM][BF 4 ] ionic liquid. The a library 28 was accomplished with impressive yields, ranging from 81 to 97 %. were successfully characterized by 1 H‐NMR, 13 C‐NMR, FT‐IR, high‐resolution mass spectral techniques. In addition, photophysical properties 17 selected derivatives, including molar extinction coefficient (ϵ) Stokes shift (Δυ̅), have been investigated. values vary between 14863 47372 5516 9766 cm −1 , respectively. On other hand, corresponding 30871 57622 9199 13351 bis‐spirooxindole‐pyrans. Furthermore, experimental data is supported density functional theory (DFT) time‐dependent DFT calculations. theoretical studies conducted demonstrated trend remarkably consistent results.

Language: Английский

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Nickel‐Catalyzed Sequential Synthesis of Alkylated Quinolines and Their Photophysical Studies

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Abstract An efficient nickel‐catalyzed sequential one‐pot strategy for the synthesis of coumarin‐appended quinolines and bis‐quinolines has been developed under mild reaction conditions in moderate to good yields (up 84 %) via dehydrogenative Friedlander annulation followed by C(sp 3 )−H functionalization. The use a cost‐effective Ni catalyst, environmentally friendly solvents simple operating procedures are attractive attributes this method. Additionally, photophysical properties synthesized derivatives were explored utilizing UV‐vis absorption fluorescence emission studies. Furthermore, large‐scale synthetic utility highlight potential applicability organic chemistry. Moreover, A plausible mechanism is supported control experiments monitoring 1 H NMR analysis.

Language: Английский

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Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 27, 2025

In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO3 nanoparticles was fabricated. The provided stable biocompatible matrix for the nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), energy-dispersive (EDS) were used to characterize confirm successful synthesis nanostructure. newly prepared bio-nanocomposite (AlFeO3@CS-SO3H) effectively employed in biologically active 7-aryl[4,3d]pyrido[1,2a]pyrimidin-6(7H)one derivatives an aqueous medium, creating environmentally friendly process. desired products manufactured high yields (88–98%) without formation noticeable side products. This procedure offers numerous advantages, short reaction times, use green solvent, ability reuse catalyst significant decrease catalytic activity, easy separation using external magnet. minimal product indicate efficiency selectivity method, making it promising strategy sustainable production compounds.

Language: Английский

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Brønsted Acid Ionic-Liquid-Catalyzed Facile One-Pot Synthesis of 1-[(1,3-Benzothiazol-2-ylamino)methyl]-2-naphthols in a Green Medium

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract A rapid, simple, and efficient one-pot protocol has been developed for the sustainable synthesis of 1-[(1,3-benzothiazol-2-ylamino)methyl]-2-naphthols from substituted 2-aminobenzothiazoles, aryl aldehydes, 2-naphthol by using 5 mol% a Bronsted acid ionic liquid as catalyst. This method offers several advantages such broad substrate scope, short reaction time, procedure, benign medium, high yield low catalyst loading. Moreover, can be recycled up to three times without noteworthy loss in catalytic activity.

Language: Английский

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Ionic Liquid-Assisted Approaches in the Synthesis of Nitrogen-Containing Heterocycles: A Focus on 3- to 6-Membered Rings

Journal of Ionic Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 100146 - 100146

Published: March 1, 2025

Language: Английский

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Green Synthetic Approach: A Well-organized Eco-friendly Tool for Synthesis of Bio-active Fused Heterocyclic Compounds

Current Green Chemistry, Journal Year: 2023, Volume and Issue: 10(1), P. 5 - 24

Published: Jan. 23, 2023

Background: Heterocyclic chemistry is a highly significant and exciting segment of organic because its high biological pharmacological activities. An environmentally benign synthetically proficient way synthesis fused heterocycles the major goal modern by developing greener synthetic strategies. Green approaches address our future challenges for development bioactive heterocycle framework with maximum productivity minimum side products. A few decades ago, novel tools manufacturing had huge impact on chemistry. Subsequently, preparation through efficient route important purpose Methods: This review consists green strategies N/O-containing various bio-active heterocyclic compounds using transformations including: cyclocondensation, cycloaddition, one-pot, multi-components, other modular reactions. Some unconventional techniques such as ultrasound microwave-assisted method, solvent solventfree reaction medium are modes adopted towards sustainability. Objective: aims to reflect sustainability scope in so that economically viable methodologies may be selectively identified applied academia industries. Conclusion: In this review, we have discussed recent advancements eco-friendly N/O-based will lead further research field.

Language: Английский

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Facile Synthesis of Bis‐Coumarins Using [BCMIM][Cl] Zwitter Ionic Liquid and Their Binding with Bovine Serum Albumin

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(8)

Published: July 6, 2023

Abstract Herein, we report a novel synthetic pathway for synthesizing bis‐coumarins using 5 mol% [BCMIM][Cl] ionic liquid via the facile, one‐pot, metal‐free synthesis in aqueous ethanol at room temperature. A series of 24 derivatives were furnished up to 94% yields 15 min 1.5 h and characterized different spectroscopic techniques. The photophysical properties bis‐coumarin explored through UV‐Visible fluorescence spectroscopy. absorption emission spectra demonstrate peak wavelength (λ max ), within range 297–311 nm 486–505 nm, respectively. An analogous pattern experimental results is seen density functional calculations. binding affinities all synthesised with Bovine Serum Albumin (BSA) determined AutoDock Vina which exhibited from −8.4 −11.5 kcal mol −1 . computed constant (K BSA ) by tryptophan (Trp) quenching values illustrate strong interactions selected ligands order 10 4 calculated validated performing molecular dynamics simulations best docking pose GROMACS software over period 1 ns studying stability protein‐ligand complexes.

Language: Английский

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