One-Pot Green Synthesis and Biological Evaluation of Dimedone-Coupled 2,3-Dihydrofuran Derivatives to Divulge Their Inhibition Potential against Staphylococcal Thioredoxin Reductase Enzyme

ACS Omega, Journal Year: 2024, Volume and Issue: 9(43), P. 43414 - 43425

Published: Oct. 21, 2024

New therapeutic leads are in global demand against multiple drug-resistant

Language: Английский

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Transition Metal‐Free Diastereoselective Synthesis of β‐Carboline Tethered Dihydrofurocoumarin Derivatives

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 13(5)

Published: Feb. 26, 2024

Abstract One‐pot procedure has been developed for the synthesis of novel β ‐carboline tethered trans 2,3‐furocoumarins via assembling 1‐formyl‐ ‐carbolines, 4‐hydroxycoumarins, and phenacyl bromides in pyridine under transition metal‐free conditions. The strategy was also found applicable to gram scale a library 40 molecules developed. significant features this operationally facile approach includes high efficiency, short reaction time, excellent yields, multicomponent character reaction, mild conditions, column chromatography free purification procedure.

Language: Английский

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Electron Donor-Acceptor Complex Enabled Photocascade Strategy for Synthesis of trans-Dihydrofuro[3,2-c]chromen-4-one Scaffolds via Radical Conjugate Addition of Pyridinium Ylide

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A photocascade strategy is disclosed for the synthesis of trans -dihydrofurocoumarin utilising EDA complex followed by 1,4-radical conjugate addition pyridinium ylide.

Language: Английский

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