ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(12)
Published: Feb. 26, 2024
Abstract
A
novel
phosphine‐free
ruthenium
pincer
complex
based
on
an
NNN
ligand
has
been
prepared
and
fully
characterized.
The
was
subsequently
employed
as
efficient
catalyst
for
the
N‐methylation
of
amines
direct
nitroarenes
using
methanol
a
C1
source
under
mild
reaction
conditions
following
borrowing‐hydrogen
approach.
Both
catalytic
transformations
were
performed
with
only
amounts
base
closed
air
without
any
other
additives.
Results in Engineering,
Journal Year:
2024,
Volume and Issue:
23, P. 102515 - 102515
Published: July 6, 2024
The
extensive
use
of
photocatalysis
to
address
environmental
concerns,
energy
production,
and
organic
transformations
has
attracted
attention
in
recent
decades.
SnO/CSO
photocatalytic
materials
were
fabricated
through
a
single-step
hydrothermal
method
comprehensively
characterized
using
muti-technique
approach
demonstrate
the
physicochemical,
morphological,
electronic
features.
According
experiments,
could
remove
>96
%
acid
blue
92
(AB92)
azo
dye
under
optimum
conditions,
with
rate
constant
2.37
×
10−2
min−1.
Furthermore,
photocatalyst
significantly
outperformed
commercial
TiO2
(P25),
reducing
CO2
CO
CH4
production
10.8
1.18
μmol
g−1
h−1,
respectively,
visible
light
irradiation.
successful
direct
alkylation
amines
valuable
compounds
within
10
min
reaction
time
conversion
selectivity
>90
was
another
capability
materials,
making
it
good
candidate
for
pharmaceutical
synthesis
purposes.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(26)
Published: Feb. 14, 2024
Abstract
This
review
provides
a
comprehensive
overview
of
mono‐alkylation
methodologies
targeting
crucial
nitrogen
moieties
–
amines,
amides,
and
sulfonamides
found
in
organic
building
blocks
pharmaceuticals.
Emphasizing
the
intersection
chemical
precision
with
drug
discovery,
central
challenge
addressed
is
achieving
one‐pot
mono‐selective
short‐chain
N‐alkylations
(methylations,
ethylations,
n
‐propylations),
preventing
undesired
overalkylation.
Additionally,
sustainable,
safe,
benign
alternatives
to
traditional
alkylating
agents,
including
alcohols,
carbon
dioxide,
carboxylic
acids,
nitriles,
alkyl
phosphates,
quaternary
ammonium
salts,
carbonates,
are
explored.
review,
categorized
by
nature
agent,
aids
researchers
selecting
suitable
methods
for
N‐alkylation.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(16)
Published: March 23, 2024
Abstract
The
N‐methylation
reaction
of
amines
with
methanol
via
the
borrowing‐hydrogen
strategy
is
an
important
method
for
construction
C−N
bonds.
Compared
other
C1
sources,
such
as
toxic
formaldehyde
or
expensive
formic
acid,
more
suitable
reactions
due
to
its
eco‐friendliness
and
low
price.
Using
this
strategy,
various
types
N‐methylated
products,
including
biological
pharmaceutical
molecules
have
been
prepared.
Here,
we
present
a
thorough
survey
decades
articles
showing
current
developments
in
methanol.
We
discuss
homogenous,
heterogenous
light‐driven
catalytic
systems
both
N,N‐dimethylation
reactions.
This
review
presents
shortcomings
provides
future
development
progress
Dalton Transactions,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Two
cobalt(
ii
)
complexes
C1
and
C2,
supported
by
an
NNN
pincer,
were
synthesized,
characterized
with
various
techniques.
These
utilized
to
study
catalytic
activity
in
the
N
-alkylation
of
amines
via
borrowing
hydrogen
strategy.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 3832 - 3852
Published: Jan. 1, 2024
Kinetic
analysis
was
performed
for
the
construction
of
biomass-based
amines
by
N
-alkylation
using
an
Ir
complex
immobilized
in
covalent
triazine
frameworks.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 11159 - 11169
Published: May 4, 2024
Herein,
we
present
a
hassle-free
approach
to
synthesize
Ni
nanoparticles
(NPs)
and
support
them
onto
oxidized
charcoal
(OC)
produce
Ni-oxidized
nanomaterials
(Ni-OC).
Subsequently,
Ni-NPs
Ni-OCs
are
characterized
using
powder
X-ray
diffraction
(PXRD),
Fourier-transform
infrared
(FTIR)
spectroscopy,
photoelectron
(XPS)
transmission
electron
microscopy
(TEM),
Brunauer–Emmett–Teller
(BET)
techniques.
The
size
distribution
curve
reveals
that
the
diameter
of
embedded
in
OC
falls
range
3–7
nm.
Surface
area
studies
show
Ni-OC
have
specific
surface
areas
36.5
248.9
m2/g,
respectively.
Interestingly,
exhibits
soft
ferromagnetic
nature
nickel.
used
as
catalysts
for
N-alkylation
reaction
between
aniline
benzyl
alcohol.
excellent
yields
(70–92%)
N-alkylated
products.
Notably,
catalyst
loading
only
0.0482
mmol
is
sufficient
activate
broad
substrate
scope
with
large
functional
group
tolerance.
In
addition,
developed
synthetic
protocol
can
be
further
exploited
catalytic
synthesis
1,2-disubstituted
benzimidazole
derivatives
(65–89%)
effective
It
has
been
observed
hydrogen-borrowing
mechanism
powers
both
processes.
outstanding
reusability
magnetic
recoverability
alcohol
more
than
seven
cycles.
contrast
Ni-NPs,
higher
activity
reaction.
This
could
explained
by
interactions
groups
available
on
charcoal,
which
enhance
Ni-OC.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(6)
Published: May 16, 2023
Abstract
This
report
describes
the
synthesis
of
a
new
N
‐(4‐(benzo[
d
]thiazole‐2‐yl)phenyl)‐1‐(pyridine‐2‐yl)methanimine
ligand
(
L1
)
by
reaction
2‐(4‐aminophenyl)benzothiazole
with
pyridine‐2‐carboxaldehyde.
The
three
ruthenium(II)
arene
complexes
were
synthesized
[RuCl
2
(p‐cymene)]
C1
),
(benzene)]
C2
and
(hmb)]
[hmb=hexamethylbenzene]
C3
).
characterized
help
standard
analytical
techniques
like
1
H
13
C{
H}
Nuclear
Magnetic
Resonance
(NMR),
Fourier
Transform
Infrared
(FTIR),
Ultraviolet‐visible
(UV‐Visible),
High‐Resolution
Mass
Spectrometry
(HRMS),
cyclic
voltammetry,
elemental
analysis
techniques.
structure
ruthenium
complex
its
bonding
mode
authenticated
single
crystal
X‐ray
diffraction.
showed
pseudo‐octahedral
half‐sandwich
“piano‐stool”
type
geometry
around
Ru
center.
–
used
to
catalyze
‐alkylation
aniline
derivatives
using
aliphatic
alcohols
(EtOH,
PrOH,
MeOH).
Among
all
catalysts,
highest
yield
alkylated
(up
95%)
1.0
mol%
catalyst
loading.
order
alkylation
toward
alcohol
was
EtOH
=
PrOH
>
MeOH.
precursors
poor
yields
(30–33%),
demonstrating
design‘s
potential
in
catalysis
reactions.
proton
NMR
mixture
after
h
shows
formation
Ru−H
intermediate,
which
gave
desired
products.
Overall,
these
are
promising
candidates
for
organic
transformation.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: Jan. 11, 2024
Abstract
Alcohols
are
widely
available
and
can
be
derived
from
renewable
resources.
Catalytic
alcohol
amination
for
N
‐alky
amine
synthesis
using
the
borrowing
hydrogen
strategy
is
an
environmentally
benign
prominent
sustainable
method,
which
produces
water
as
sole
byproduct.
However,
expensive
noble
metals
generally
employed
this
transformation,
while
nonprecious
metal‐based
catalysts
were
also
known
reaction
have
attracted
considerable
attention
recently.
Herein,
efficient
‐alkylation
of
amines
with
alcohols
base‐metal
cobalt
reported.
This
catalyzed
by
N‐heterocyclic
carbene
cobalt‐pincer
catalyst
operates
simply
under
mild
conditions.
Various
aniline
substrates
functional
groups
including
nitrile,
ether,
thioether
alkene
could
well
tolerated.
Moreover,
experimental
studies
DFT
calculations
performed
to
illustrate
mechanism.
Our
results
suggest
that
proceeds
via
a
autotransfer
