Preparation and evaluation of transdermal hydrogel of chitosan coated nanocurcumin for enhanced stability and skin permeability

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(12), P. 105302 - 105302

Published: Sept. 25, 2023

Curcumin (CR) is a natural product that has great interest in biopharmaceutical applications. It several biological effects antagonizes inflammation, oxidative stress, and cancer. On the other hand, low aqueous solubility, stability, dissolution rate are main challenges to using curcumin. In present investigation, curcumin was formulated as nanosystem known nanocurcumin combination of polyvinyl pyrrolidone (PVP) with different polymers stabilizing agents. The formulations were prepared evaluated by measuring particle size, surface charge, drug content, stability. selected formulation PVPK30-Poloxamer 188 demonstrated significantly smaller size (272.1 ± 15.32 nm) higher settlement volume ration compared formulations. Also, showed solubility rates stabilizer combinations. Chitosan added coating polymer enhance short-term storage colloidal result stability proved chitosan (0.05%)-coated dispersion good during non-coated nanocurcumin. Non-coated chitosan-coated loaded into Carbopol934 hydrogel matrix investigate effect on permeability across skin. results revealed amount permeated

Language: Английский

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Hierarchical Integration of Curcumin‐Loaded CaCO₃ Nanoparticles and Black Phosphorus Nanosheets in Core/Shell Nanofiber for Cranial Defect Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Reconstruction and healing of large craniofacial bone defects are major clinical challenges due to high risk chronic inflammation reduced cell mineralization levels. Herein, a core‐shell nanofiber‐based implant with significant pro‐osteogenesis capability for treating skull is reported, which hierarchically integrated curcumin‐loaded calcium carbonate nanoparticles (CaCO 3 @Cur NPs) in the outer layers black phosphorus nanosheets (BPNSs) core compartments. The radical alignment nanocomponents allows sequential situ release therapeutic agents controlled manner after implantation. Curcumin can repolarize M1 macrophages into M2 phenotypes anti‐inflammation purposes. Meanwhile, released phosphate ions promote biomineralization hydroxyapatite at defect site facilitate regeneration. Evaluations on cranial defect‐bearing rat models demonstrated that electrospun fibers present study substantially promoted restoration damaged skulls inhibited wound bed. This strategy provides new idea treatment clinic.

Language: Английский

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Boosting Curcumin Bioavailability with Egg White Protein Aerogels: A Sustainable Supercritical CO₂-Based Approach for Enhanced Bioaccessibility, Antioxidant Activity, and Anti-Inflammatory Effects

Future Foods, Journal Year: 2024, Volume and Issue: unknown, P. 100532 - 100532

Published: Dec. 1, 2024

Language: Английский

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Enhanced Breast Cancer Therapy Using Multifunctional Lipid- Coated Nanoparticles Combining Curcumin Chemotherapy and Nitric Oxide Gas Delivery

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

The limitations of conventional treatment modalities for cancer, particularly breast have promoted the need to develop safer drug delivery systems (DDS). Chemotherapy combined with gas therapy has emerged as an attractive cancer strategy. In this study, curcumin (Cur) loaded amorphous calcium carbonate nanoparticles (Cur-CaCO₃) were prepared by diffusion reaction. A "one-step" ethanol injection method was then used prepare lipid-coated (Cur-CaCO₃@LA-Lip) L-arginine (LA) achieve a combination chemotherapy and NO enhance antitumor effect. Cur-CaCO₃@LA-Lip characterized evaluated transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis spectrometry, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) differential scanning calorimetry (DSC). TEM observed that subspherical had distinct lipid layer covering periphery. FTIR, XRD, DSC indicated successful synthesis Cur-CaCO₃@LA-Lip. exhibited large loading capacity 8.89% 3.1% Cur LA, respectively, effectively preventing leakage. Furthermore, in vitro vivo, sustained-release, high cellular uptake, tumor accumulation, good biocompatibility, robust cytotoxicity, efficacy.

Language: Английский

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Dihydroxyphenylalanine-conjugated high molecular weight polyethylenimine for targeted delivery of Plasmid

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 4, 2024

Language: Английский

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