Biomimetics,
Journal Year:
2023,
Volume and Issue:
9(1), P. 5 - 5
Published: Dec. 23, 2023
The
3D
(three-dimensional)
micro–nanostructured
diatom
biosilica
obtained
from
cultivated
diatoms
was
used
as
a
support
to
immobilize
epitaxially
growing
AgCl-Ag
hybrid
nanoparticles
((Ag-AgCl)NPs)
for
the
synthesis
of
nanocomposites
with
antimicrobial
properties.
prepared
composites
that
contained
grown
(Ag-AgCl)NPs
were
investigated
in
terms
their
morphological
and
structural
characteristics,
elemental
mineral
composition,
crystalline
forms,
zeta
potential,
photoluminescence
properties
using
variety
instrumental
methods
including
SEM
(scanning
electron
microscopy),
TEM
(transmission
EDX
(energy-dispersive
X-ray
spectroscopy),
XRD
(X-ray
powder
diffraction),
zeta-potential
measurement,
spectroscopy.
content
(AgCl-Ag)NPs
amounted
4.6
mg/g
8.4
AgClNPs/AgNPs
ratios
percentage
86/14
51/49,
respectively.
Hybrid
evenly
dispersed
dominant
size
5
25
nm
composite
an
amount
silver.
average
7.5
nm;
also,
there
1–2
particles
20–40
nm.
potential
mechanism
studied.
MIC
(the
minimum
inhibitory
concentration
method)
approach
investigate
activity
against
microorganisms
Klebsiella
pneumoniae,
Escherichia
coli,
Staphylococcus
aureus.
containing
natural
showed
resistance
bacterial
strains
American
Type
Cultures
Collection
clinical
isolates
(diabetic
foot
infection
wound
isolates).
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(13), P. 9080 - 9098
Published: Jan. 1, 2024
Two
novel
metal–organic
frameworks
(MOFs),
synthesized
from
4,6-diamino-2-pyrimidinethiol
with
Zn
and
Co
metal
ions,
display
antibacterial,
antibiofilm,
antioxidant
properties,
serving
multifunctionality
in
biological
environmental
domains.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(2), P. 173 - 173
Published: Feb. 9, 2024
Nanotechnology
has
emerged
as
a
cornerstone
in
contemporary
research,
marked
by
the
advent
of
advanced
technologies
aimed
at
nanoengineering
materials
with
diverse
applications,
particularly
to
address
challenges
human
health.
Among
these
challenges,
antimicrobial
resistance
(AMR)
risen
significant
and
pressing
threat
public
health,
creating
obstacles
preventing
treating
persistent
diseases.
Despite
efforts
recent
decades
combat
AMR,
global
trends
indicate
an
ongoing
concerning
increase
AMR.
The
primary
contributors
escalation
AMR
are
misuse
overuse
various
agents
healthcare
settings.
This
led
severe
consequences
not
only
terms
compromised
treatment
outcomes
but
also
substantial
financial
burdens.
economic
impact
is
reflected
skyrocketing
costs
attributed
heightened
hospital
admissions
increased
drug
usage.
To
this
critical
issue,
it
imperative
implement
effective
strategies
for
therapies.
comprehensive
review
will
explore
latest
scientific
breakthroughs
within
metal–organic
frameworks
use
mesoporous
metallic
oxide
derivates
agents.
We
their
biomedical
applications
shedding
light
on
promising
avenues
combating
Finally,
we
conclude
current
state
research
offer
perspectives
future
development
nanomaterials
battle
against
Industrial & Engineering Chemistry Research,
Journal Year:
2023,
Volume and Issue:
62(11), P. 4729 - 4737
Published: March 6, 2023
In
biomedical
applications,
biocompatible
and
nontoxic
compounds
are
the
most
critical
types
of
cytotoxic
effects.
this
work,
nanobiomaterial
MCC/IL/Ag-AgCl
NPs
were
fabricated
by
immobilizing
Ag-AgCl
nanoparticles
on
surface
organic
biopolymer
[microcrystalline
cellulose
(MCC)]
without
using
any
reducing
agent.
The
physical
chemical
properties
characterized
techniques
including
transmission
electron
microscopy
(TEM),
scanning
(SEM),
energy-dispersive
X-ray
(EDX)
analysis,
diffraction
(XRD),
FOurier
transform
infrared
(FT-IR)
spectroscopy,
atomic
absorption
spectroscopy
(AAS).
in
vitro
antibacterial
activity
was
investigated
methicillin-resistant
Staphylococcus
aureus
(ATCC-43300)
multidrug-resistant
Pseudomonas
aeruginosa
(ATCC-27853).
results
such
as
MIC
MBC
illustrated
that
antimicrobial
effect
against
(1–2
μg/mL
value)
higher
than
(4
also
microtiter
plate
method,
antibiofilm
MCC/IL/Ag-AgClNPs
remarkable
a
variety
low
concentrations
(32,
16,
8,
4,
2,
1
μg/mL).
Besides,
cytotoxicity
study
(cell
death
induction)
Caco-2
cells
revealed
toxic
effects
different
doses
up
to
400
ppm
for
MCC/IL
support,
which
further
confirmed
products.
It
is
expected
these
can
inhibit
biofilm
formation
bacteria
surfaces
equipment,
reduce
nosocomial
infections,
hospital
environments,
especially
intensive
care
unit,
surgery
unit/room.
