Nobiletin-rich kososan, a Kampo formula, prevents the onset of apathy-like behavior and neuroinflammation in sickness behavior mouse model induced by increasing doses of lipopolysaccharide DOI Creative Commons
Naoki Ito,

Rieko Miki,

Naoya Kawada

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Highlights•Post-infection depression poses significant clinical challenges.•Repeated NKS treatment prevents LPS-induced apathy-like behavior in mice.•NKS neuroinflammation by increasing anti-inflammatory milieu.•NKS ameliorates brain vascular inflammation.•NKS may be useful for preventing post-infection depression.AbstractInfectious diseases are often concomitant with symptoms of lassitude and emotional disturbances, including depression, the so-called sickness behavior. Kososan, a Kampo (traditional Japanese herbal) formula, has been clinically used depressive mood, demonstrated efficacy stress-induced depressive-like mouse models. Additionally, our previous study shown that nobiletin-rich kososan (NKS) aging-related behaviors mice. Here, we examined whether alleviates model induced lipopolysaccharide (LPS). Repeated oral administration positive control antidepressant paroxetine (Paro) significantly prevented this Paro increased milieu hippocampus prefrontal cortex (PFC), as well microglia, LPS-injected The expression tight junction protein claudin-5 was also NKS, but not Paro, PFC In vitro analysis using microvascular endothelial cells (BMVECs) showed incubation 5% serum derived from mice orally administered resulted increase heme oxygenase 1 autophagic flux markers. Moreover, levels BMVECs were under LPS-stimulated conditions. These results suggest exerts prophylactic effects against behavior, partly mediated proteins brain. This provides scientific evidence supporting potential depression.

Language: Английский

SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-β/smad signaling pathway DOI Creative Commons
Yu Xia, Qihui Luo, Qi Gao

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 110979 - 110979

Published: March 28, 2024

TGF-β/Smad signaling pathway plays an important role in the pathogenesis and progression of liver fibrosis. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+) dependent enzyme responsible for deacetylating proteins. Increasing numbers reports have shown that molecular mechanism SIRT1 as effective therapeutic target fibrosis but transformation not very clear. In present study, fibrotic tissues were screened by staining with Masson, hematoxylin-eosin (H&E) Immunohistochemistry (IHC) histopathological observation from biopsy seventy-seven rhesus monkey, which fixed 4% paraformaldehyde (PFA) after treatment high-fat diet (HFD) two years. And function was further determined serum biochemical tests. The mRNA levels protein expression rat hepatic stellate (HSC-T6) cells Resveratrol (RSV) Nicotinamide (NAM), respectively. results showed increasing monkeys, impaired, transforming growth factor-β1 (TGF-β1), p-Smad3 (p-Smad3) alpha-smooth muscle actin (α-SMA) up-regulated, while Smad7 down-regulated. Moreover, when stimulated HSC-T6 RSV to activate 6, 12, 24 h, promoted smad7, TGF-β1, α-SMA inhibited. contrast, NAM inhibit decreased, p-Smad3, expressions increased. These indicate acts protective factor fibrosis, may be attributed inhibiting monkey.

Language: Английский

Citations

5
The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target DOI Creative Commons

Mufei Wang,

Juanjuan Zhao,

Jiuxia Chen

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17094 - e17094

Published: March 29, 2024

Liver disease is a common and serious threat to human health. The progression of liver diseases influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, autophagy. Various factors lead the dysfunction these processes basing on different pathogeny, pathology, clinical manifestation, pathogenesis, are grouped into categories. Specifically, Sirtuin1 (SIRT1), member sirtuin protein family, has been extensively studied in context injury recent years confirmed significant role disease. SIRT1 found play critical regulating key injury. Further, seems cause divers outcomes types diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring novel target. To elucidate mechanisms underlying sirtuin1 its potentiality as target, this review outlines signaling pathways associated with injury, discusses advances targeting

Language: Английский

Citations

5
Sinensetin, a polymethoxyflavone from citrus fruits, ameliorates LPS-induced acute lung injury by suppressing Txnip/NLRP3/Caspase-1/GSDMD signaling-mediated inflammatory responses and pyroptosis DOI

Zaibin Xu,

Hui-Yu Hu,

Kongyan Wang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(14), P. 7592 - 7604

Published: Jan. 1, 2024

The functional effect and molecular mechanism diagram of SIN ameliorated ALI.

Language: Английский

Citations

4
HDAC3: A Multifaceted Modulator in Immunotherapy Sensitization DOI Creative Commons
Rui Han, Yi‐Bo Luo,

Jingdong Gao

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 182 - 182

Published: Feb. 13, 2025

Histone deacetylase 3 (HDAC3) has emerged as a critical epigenetic regulator in tumor progression and immune modulation, positioning it promising target for enhancing cancer immunotherapy. This work comprehensively explores HDAC3's multifaceted roles, focusing on its regulation of key immune-modulatory pathways such cGAS-STING, ferroptosis, the Nrf2/HO-1 axis. These are central to evasion, antigen presentation, cell activation. Additionally, distinct effects HDAC3 various types-including role T activation, restoring NK cytotoxicity, promoting dendritic maturation, modulating macrophage polarization-are thoroughly examined. findings underscore capacity reshape microenvironment, converting immunologically "cold tumors" into "hot thereby increasing their responsiveness The therapeutic potential inhibitors is highlighted, both standalone agents combination with checkpoint inhibitors, overcome resistance improve treatment efficacy. Innovative strategies, development selective advanced nano-delivery systems, integration photodynamic or photothermal therapies, proposed enhance precision minimize toxicity. By addressing challenges toxicity, patient heterogeneity, mechanisms, this study provides forward-looking perspective clinical application inhibitors. It highlights significant personalized immunotherapy, paving way more effective treatments improved outcomes patients.

Language: Английский

Citations

0
Cirsium japonicum leaf extract attenuated lipopolysaccharide-induced acute respiratory distress syndrome in mice via suppression of the NLRP3 and HIF1α pathways DOI
Eun Yeong Lim,

Gun‐Dong Kim,

Ha‐Jung Kim

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156601 - 156601

Published: March 2, 2025

Language: Английский

Citations

0
Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice DOI
Zuomin Hu,

Zhongxing Chu,

Xuke Ling

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105066 - 105066

Published: Sept. 6, 2024

Language: Английский

Citations

2
Integration of microbiomics, metabolomics, and transcriptomics reveals the therapeutic mechanism underlying Fuzheng-Qushi Decoction for the treatment of lipopolysaccharide-induced lung injury in mice DOI
Kai-En Guo, Yuting Yin,

Linxin Zheng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118584 - 118584

Published: July 15, 2024

Language: Английский

Citations

1
Nobiletin-rich kososan, a Kampo formula, prevents the onset of apathy-like behavior and neuroinflammation in sickness behavior mouse model induced by increasing doses of lipopolysaccharide DOI Creative Commons
Naoki Ito,

Rieko Miki,

Naoya Kawada

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Highlights•Post-infection depression poses significant clinical challenges.•Repeated NKS treatment prevents LPS-induced apathy-like behavior in mice.•NKS neuroinflammation by increasing anti-inflammatory milieu.•NKS ameliorates brain vascular inflammation.•NKS may be useful for preventing post-infection depression.AbstractInfectious diseases are often concomitant with symptoms of lassitude and emotional disturbances, including depression, the so-called sickness behavior. Kososan, a Kampo (traditional Japanese herbal) formula, has been clinically used depressive mood, demonstrated efficacy stress-induced depressive-like mouse models. Additionally, our previous study shown that nobiletin-rich kososan (NKS) aging-related behaviors mice. Here, we examined whether alleviates model induced lipopolysaccharide (LPS). Repeated oral administration positive control antidepressant paroxetine (Paro) significantly prevented this Paro increased milieu hippocampus prefrontal cortex (PFC), as well microglia, LPS-injected The expression tight junction protein claudin-5 was also NKS, but not Paro, PFC In vitro analysis using microvascular endothelial cells (BMVECs) showed incubation 5% serum derived from mice orally administered resulted increase heme oxygenase 1 autophagic flux markers. Moreover, levels BMVECs were under LPS-stimulated conditions. These results suggest exerts prophylactic effects against behavior, partly mediated proteins brain. This provides scientific evidence supporting potential depression.

Language: Английский

Citations

0