Exploring the bioactive properties, extraction methods, and detection techniques of phlorotannins from brown algae: implications for health and nutraceutical applications

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: Jan. 29, 2025

Language: Английский

---

Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: From action mechanism to therapeutic target in clinical trials

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Jan. 18, 2025

The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a critical modulator in inflammatory disease. Activation mutation of NLRP3 can cause severe inflammation diseases such as chronic infantile neurologic cutaneous articular syndrome, Muckle-Wells familial cold autoinflammatory syndrome 1. To date, great effort has been made to decode the underlying mechanisms activation. priming activation drive maturation release active interleukin (IL)-18 IL-1β pyroptosis, which significantly trigger many including diseases, immune disorders, metabolic neurodegenerative diseases. investigation therapeutic target for disease treatment hot topic both preclinical studies clinical trials. Developing potent inhibitors downstream IL-1 attracts wide-spectrum attention research pharmaceutical fields. In this minireview, we first updated molecular involved associated signaling pathways. We then reviewed cellular pathways obesity, diabetes, other addition, briefly roles cancer growth relative checkpoint therapy. Finally, trials with treatments targeting its were summarized.

Language: Английский

---

HPTLC hyphenated with planar effect-directed assays (EDA) for the rapid screening and evaluation of macro algae fermentation with respect to their antioxidant and anti-inflammatory activity

Algal Research, Journal Year: 2025, Volume and Issue: unknown, P. 103978 - 103978

Published: Feb. 1, 2025

Language: Английский

---

Rodent Models for Alzheimer Disease: Experimental Induction, Pathophysiological Mechanisms, and Biomarker Profiling

Published: May 1, 2025

Background Alzheimer’s disease (AD), the most common neurodegenerative disorder, is driven by amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), neuroinflammation, and oxidative stress. Rodent models are critical for studying its multifactorial etiology, combining genetic, environmental, epigenetic factors. This review evaluates rodent AD models, including chemical induction (e.g., aluminum, scopolamine) transgenic systems 5xFAD, APP/PS1). Chemical mimic sporadic triggers, while transgenics replicate genetic mutations. Combinatorial approaches toxin- exposed transgenics) address limitations. Biomarkers such as Aβ/tau ratios, neuroinflammatory cytokines (TNF-α, IL-1β), stress markers (MDA, SOD) validate pathology, measured via ELISA, PET imaging, omics technologies.

Language: Английский

---

Marine algae-derived nanoparticles (MADNs): green synthesis, characterization, and therapeutic applications

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(5)

Published: May 6, 2025

Abstract Marine algae, a reservoir of bioactive compounds, offer immense therapeutic potential, especially when harnessed through nanotechnology. This review comprehensively explores the synthesis, characterization, and applications marine algae-derived nanoparticles (MADNs), with particular focus on their antioxidant properties. notably red possess unique biochemical compositions rich in polyphenols, flavonoids, polysaccharides, carotenoids. These compounds confer robust capacities, protecting algae from oxidative stress induced by environmental extremities. The details how these molecules can be synthesized into nanoparticles, leveraging green synthesis methods that utilize algae's intrinsic reducing stabilizing agents, promoting sustainable nanoparticle production. integration nanotechnology amplifies efficacy MADNs demonstrating superior reactivity, stability, bioavailability. Characterization advanced techniques like TEM, XRD, FTIR has underscored potential mitigating damage cellular models. By scavenging reactive oxygen species (ROS), show promise interventions for conditions linked to stress, including cancer neurodegenerative diseases. highlights dual benefits sustainability enhanced provided MADNs. approach not only minimizes footprint but also ensures bioactivity nanoparticles. clinical implications are profound, suggesting new paradigm development eco-friendly agents. findings presented herein aim stimulate further research underscore pivotal role advancing nanomedicine.

Language: Английский

---

Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2996 - 2996

Published: Sept. 5, 2024

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations efficacy tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, terpenoids, have demonstrated anti-inflammatory effects both preclinical clinical studies. By modulating responses promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies MS. This review provides insights into molecular cellular basis MS pathogenesis, emphasizing role inflammation disease progression. It critically evaluates emerging evidence supporting use plant-derived to attenuate symptomology. In addition, we provide comprehensive source information detailing known mechanisms action assessing context with focus on their neuroprotective properties.

Language: Английский

---

Antioxidant, Antimicrobial, and Anti-Inflammatory Effects of Liriodendron chinense Leaves

ACS Omega, Journal Year: 2024, Volume and Issue: 9(25), P. 27002 - 27016

Published: June 10, 2024

Liriodendron chinense has been widely utilized in traditional Chinese medicine to treat dispelling wind and dampness used for alleviating cough diminishing inflammation. However, the antioxidant, antimicrobial, anti-inflammatory effects of L. leaves key active constituents remained elusive. So, we conducted some experiments support application by investigating antibacterial, abilities, identify potential responsible activities. The ethanol extract (LCLE) was isolated extracted, assays measuring ferric reducing antioxidant power, total DPPH•, ABTS•+, •OH were assess its vitro capacities. Antimicrobial activities LCLE investigated minimal inhibitory levels, minimum antibacterial concentrations, disc diffusion test, scanning electron microscope examination. Further, vivo including macro indicators examination, histopathological biochemical parameters measurement investigate on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. further purified through column chromatography, LPS-induced RAW264.7 cells constructed diminished inflammation identified chemical composites. ABTS•+ radicals extensively neutralized treatment. administration also presented broad-spectrum antimicrobial properties, especially against Staphylococcus epidermidis disrupting cell walls. ALI mice significantly ameliorated intervention, as evidenced histological changes liver tissues well reductions nitric oxide (NO), TNF-α, IL-6 production. Furthermore, three novel compounds fragransin B2, liriodendritol, rhamnocitrin isolated, purified, from LCLE. These exhibited differential regulation NO accumulation IL-10, IL-1β, IL-6, COX-2, iNOS mRNA expression induced LPS. Fragransin B2 more effective inhibiting TNF-α expression, while powerful expression. had significant effects. probably LCLE, which might act synergistically inflammatory-related disorders. This study provided a valuable view healing curing inflammatory diseases.

Language: Английский

---

Microalgae: An Exciting Alternative Protein Source and Nutraceutical for the Poultry Sector

Food Science of Animal Resources, Journal Year: 2024, Volume and Issue: 45(1), P. 243 - 265

Published: Dec. 20, 2024

Microalgae have garnered a considerable attention as sustainable substitute customary feed ingredients for poultry, predominantly due to their extraordinary nutritive profile and purposeful properties. These minuscule organisms are protein rich, retain an ample quantity of essential fatty acids, vitamins, minerals, antioxidants, thus capable improving value poultry diets. comparatively delivers outstanding source containing substantial amount innumerable bioactive complexes, omega-3 acids in addition the amino (methionine lysine), crucial optimal growth development. Besides nutritional significance, microalgae immunomodulatory antioxidant properties that help reduce oxidative stress enhance immune status, thereby overall health performance. Additionally, proved induce antimicrobial intestinal benefits via upregulated gut eubiosis, promoting colonization probiotic bacteria offering protection against infections. nutraceutical particularly important production reducing dependence on antibiotic promoters produce free food. This review aims highlights multifaceted advantages functional additive diet support efficient production.

Language: Английский

---