Coenzyme-Protein Interactions since Early Life
Published: Feb. 26, 2024
Recent
findings
in
protein
evolution
and
peptide
prebiotic
plausibility
have
been
setting
the
stage
for
reconsidering
role
of
peptides
early
stages
life’s
origin.
Ancient
families
found
to
share
common
themes
proteins
reduced
composition
prebiotically
plausible
amino
acids
reported
capable
structure
formation
key
functions,
such
as
binding
RNA.
While
this
may
suggest
relevance
life,
their
functional
repertoire
when
composed
a
limited
number
residues
(missing
some
most
sophisticated
groups
today’s
alphabet)
has
debated.Cofactors
enrich
scope
about
half
extant
enzymes
but
whether
they
could
also
bind
lacking
evolutionary
late
remains
speculative.
The
aim
study
was
resolve
propensity
organic
cofactors
by
analysis
protein-coenzyme
interactions
across
Protein
Data
Bank
(PDB).
We
find
that
are
more
abundant
sites
ancient
coenzymes
rely
frequently
on
involvement
backbone
atoms
metal
ion
cofactors.
Moreover,
we
identified
few
select
examples
where
coenzyme
is
supported
solely
available
acids.
These
results
imply
coenzyme-peptide
collaboration
preceding
establishment
Central
Dogma
full
alphabet
evolution.
Language: Английский
A Systematic Investigation of TMB Substrate Composition for Signal Enhancement in ELISA
Analytical Biochemistry,
Journal Year:
2025,
Volume and Issue:
704, P. 115908 - 115908
Published: May 23, 2025
Language: Английский
Peptides En Route from Prebiotic to Biotic Catalysis
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(15), P. 2027 - 2037
Published: July 17, 2024
ConspectusIn
the
quest
to
understand
prebiotic
catalysis,
different
molecular
entities,
mainly
minerals,
metal
ions,
organic
cofactors,
and
ribozymes,
have
been
implied
as
key
players.
Of
these,
inorganic
cofactors
gained
attention
for
their
ability
catalyze
a
wide
array
of
reactions
central
modern
metabolism
frequently
participate
in
these
within
enzymes.
Nevertheless,
bridging
gap
between
remains
fundamental
question
origins
life.In
this
Account,
peptides
are
investigated
potential
bridge
linking
catalysis
by
minerals/cofactors
enzymes
that
dominate
life's
chemical
reactions.
Before
ribosomal
synthesis
emerged,
random
sequences
were
plausible
on
early
Earth.
This
was
made
possible
sources
amino
acid
delivery
synthesis,
well
condensation
under
variety
conditions.
Early
proteins
probably
exhibited
distinct
compositions,
enriched
small
aliphatic
acidic
residues.
An
increase
abundance
acids
with
larger
side
chains
canonical
basic
groups
most
likely
dependent
emergence
more
challenging
(bio)synthesis.
Pressing
questions
thus
arise:
how
did
composition
influence
peptide
properties,
what
extent
could
they
contribute
metabolism?Recent
research
from
our
group
colleagues
shows
highly
peptides/proteins
comprising
only
presumably
"early"
fact
competent
at
secondary
structure
formation
even
possess
adaptive
folding
characteristics
such
spontaneous
refoldability
chaperone
independence
achieve
soluble
structures.
Moreover,
we
showed
can
still
bind
RNA
utilizing
ions
carboxylate
phosphoester
functional
groups.
And
finally,
ancient
shown
be
capable
binding
considered
prebiotically
plausible,
supporting
properties
providing
groups,
which
would
nominate
them
catalytic
hubs
great
relevance.These
findings
underscore
biochemical
plausibility
an
peptide/protein
world
devoid
complex
yet
collaborating
other
species.
Drawing
mechanistic
protein-cofactor
it
is
speculated
here
peptide/protein-cofactor
ensemble
facilitate
similar
range
reactions,
albeit
lower
rates.
hypothesis
invites
systematic
experimental
test.Nonetheless,
Account
does
not
exclude
scenarios
prebiotic-to-biotic
or
prioritize
any
specific
pathways
syntheses.
The
objective
examine
availability,
composition,
among
various
factors
involved
life.
Language: Английский
Protocellular Heme and Iron–Sulfur Clusters
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(16), P. 2293 - 2302
Published: Aug. 5, 2024
ConspectusCentral
to
the
quest
of
understanding
emergence
life
is
uncover
role
metals,
particularly
iron,
in
shaping
prebiotic
chemistry.
Iron,
as
most
abundant
accessible
transition
metals
on
Earth,
played
a
pivotal
early
biochemical
processes
and
continues
be
indispensable
modern
biology.
Here,
we
discuss
our
recent
contributions
probing
plausibility
complexes
with
including
heme
iron-sulfur
clusters,
mediating
chemistry
beneficial
protocell.
Laboratory
experiments
spectroscopic
findings
suggest
plausible
pathways,
often
facilitated
by
UV
light,
for
synthesis
clusters.
Once
formed,
displays
catalytic,
peroxidase-like
activity
when
complexed
amphiphiles.
This
could
have
been
two
ways.
First,
catalytically
removed
molecule
(H
Language: Английский
Coenzyme-Protein Interactions since Early Life
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 1, 2023
Abstract
Recent
findings
in
protein
evolution
and
peptide
prebiotic
plausibility
have
been
setting
the
stage
for
reconsidering
role
of
peptides
early
stages
life’s
origin.
Ancient
families
found
to
share
common
themes
proteins
reduced
composition
prebiotically
plausible
amino
acids
reported
capable
structure
formation
key
functions,
such
as
binding
RNA.
While
this
may
suggest
relevance
life,
their
functional
repertoire
when
composed
a
limited
number
residues
(missing
some
most
sophisticated
groups
today’s
alphabet)
has
debated.
Cofactors
enrich
scope
about
half
extant
enzymes
but
whether
they
could
also
bind
lacking
evolutionary
late
remains
speculative.
The
aim
study
was
resolve
propensity
organic
cofactors
by
analysis
protein-coenzyme
interactions
across
Protein
Data
Bank
(PDB).
We
find
that
are
more
abundant
sites
ancient
coenzymes
rely
frequently
on
involvement
backbone
atoms
metal
ion
cofactors.
Moreover,
we
identified
few
select
examples
where
coenzyme
is
supported
solely
available
acids.
These
results
imply
coenzyme-peptide
collaboration
preceding
establishment
Central
Dogma
full
alphabet
evolution.
Language: Английский
Coenzyme-Protein Interactions since Early Life
Published: Feb. 26, 2024
Recent
findings
in
protein
evolution
and
peptide
prebiotic
plausibility
have
been
setting
the
stage
for
reconsidering
role
of
peptides
early
stages
life’s
origin.
Ancient
families
found
to
share
common
themes
proteins
reduced
composition
prebiotically
plausible
amino
acids
reported
capable
structure
formation
key
functions,
such
as
binding
RNA.
While
this
may
suggest
relevance
life,
their
functional
repertoire
when
composed
a
limited
number
residues
(missing
some
most
sophisticated
groups
today’s
alphabet)
has
debated.Cofactors
enrich
scope
about
half
extant
enzymes
but
whether
they
could
also
bind
lacking
evolutionary
late
remains
speculative.
The
aim
study
was
resolve
propensity
organic
cofactors
by
analysis
protein-coenzyme
interactions
across
Protein
Data
Bank
(PDB).
We
find
that
are
more
abundant
sites
ancient
coenzymes
rely
frequently
on
involvement
backbone
atoms
metal
ion
cofactors.
Moreover,
we
identified
few
select
examples
where
coenzyme
is
supported
solely
available
acids.
These
results
imply
coenzyme-peptide
collaboration
preceding
establishment
Central
Dogma
full
alphabet
evolution.
Language: Английский
Coenzyme-Protein Interactions since Early Life
Published: Oct. 16, 2024
Recent
findings
in
protein
evolution
and
peptide
prebiotic
plausibility
have
been
setting
the
stage
for
reconsidering
role
of
peptides
early
stages
life’s
origin.
Ancient
families
found
to
share
common
themes
proteins
reduced
composition
prebiotically
plausible
amino
acids
reported
capable
structure
formation
key
functions,
such
as
binding
RNA.
While
this
may
suggest
relevance
life,
their
functional
repertoire
when
composed
a
limited
number
residues
(missing
some
most
sophisticated
groups
today’s
alphabet)
has
debated.Cofactors
enrich
scope
about
half
extant
enzymes
but
whether
they
could
also
bind
lacking
evolutionary
late
remains
speculative.
The
aim
study
was
resolve
propensity
organic
cofactors
by
analysis
protein-coenzyme
interactions
across
Protein
Data
Bank
(PDB).
We
find
that
are
more
abundant
sites
ancient
coenzymes
rely
frequently
on
involvement
backbone
atoms
metal
ion
cofactors.
Moreover,
we
identified
few
select
examples
where
coenzyme
is
supported
solely
available
acids.
These
results
imply
coenzyme-peptide
collaboration
preceding
establishment
Central
Dogma
full
alphabet
evolution.
Language: Английский