Beyond the Hayflick limit: How microbes influence cellular aging

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

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β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

Food & Function, Journal Year: 2024, Volume and Issue: 15(6), P. 3199 - 3213

Published: Jan. 1, 2024

NMN prolonged the life span and delayed senescence in premature ageing mice.

Language: Английский

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The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases

Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 166 - 189

Published: June 18, 2024

The human gut microbiome is well-recognized as a key player in maintaining health. However, it dynamic entity that changes across the lifespan. How microbial occur later decades of life shape host health or impact age-associated inflammatory neurological diseases such multiple sclerosis (MS) still unclear. Current understanding aging largely limited to cross-sectional observational studies. Moreover, studies humans are by confounding host-intrinsic and extrinsic factors not easily disentangled from aging. This review provides comprehensive summary existing literature on its known relationships with diseases, specific focus MS. We will also discuss preclinical animal models shed light complex microbiota-host interactions have potential influence disease pathology progression individuals. Lastly, we propose avenues investigation deconvolute features an microbiota contribute disease, alternatively promote advanced age.

Language: Английский

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Gut Microbial Dysbiosis Differs in Two Distinct Cachectic Tumor-Bearing Models Consuming the Same Diet

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1076 - 1076

Published: April 6, 2024

The impact of cancer cachexia on the colonic microbiota is poorly characterized. This study assessed effect two cachectic-producing tumor types gut to determine if a similar dysbiosis could be found. In addition, it was determined diet containing an immunonutrient-rich food (walnuts) known promote growth probiotic bacteria in colon alter and slow cachexia. Male Fisher 344 rats were randomly assigned semi-purified with or without walnuts. Then, within each group, further treatment group: tumor-bearing ad libitum fed (TB), non-tumor-bearing (NTB-AL), group pair-fed TB (NTB-PF). implanted either Ward carcinoma MCA-induced sarcoma, both transplantable lines. Fecal samples collected after development cachexia, species identified using 16S rRNA gene analysis. Both groups developed but had differently altered microbiome. Beta diversity unaffected by (NTB-AL, TB, NTB-PF) regardless type affected diet. Also, consistently changed relative abundance several taxa, while did not. control increased A. Anaeroplasma, walnut genus Ruminococcus. There no common fecal bacterial changes characteristic Diet microbiota, these insufficient progression suggesting more complex than few shifts.

Language: Английский

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High exposure to carrageenan in young mice may impair behavior, immunity, redox and inflammatory states throughout the aging process

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115143 - 115143

Published: Sept. 27, 2024

Language: Английский

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