Comparative analysis of glimepiride interactions with bovine serum albumin and fibrinogen using fluorescence spectroscopy DOI Creative Commons

Apoorva Pathania,

Harman Deep Kour,

Monika Bhattu

et al.

E3S Web of Conferences, Journal Year: 2024, Volume and Issue: 588, P. 02017 - 02017

Published: Jan. 1, 2024

Bovine Serum Albumin (BSA) and Fibrinogen (Fib) are the model proteins extensively used for investigating drug-protein interactions due to their distinct binding characteristics structural similarities human serum albumin. The present report examines between Glimepiride (GM) [a sulfonylurea Type 2 Diabetes mellitus management) Fib And BSA, respectively. Fluorescence spectroscopy was employed analyze quenching mechanisms constants at 298 K 290 K, results indicate that GM binds BSA via hydrophobic forces, with rate showing significant interactions. constant ( k b ) interaction GM-Fib found be 1.297 × 10 4 Lmol -1 1.262× respectively Gibbs free energy (ΔG) equal -5.609 Kcal/mol, -3.627 Kcal/mol GM- determined 1.24 5 Lmol⁻¹ 9.896 3 K. ΔG associated these is -6.947 -5.302 thermodynamic parameters suggest spontaneous processes a negative value of ΔG. provide valuable insights into GM’s stability contributing understanding essential drug development.

Language: Английский

Water-soluble dinuclear zinc(II) complexes bridged by auxiliary para-substituted benzoate ligands: synthesis, structure, spectroscopic characterization and protein binding affinity DOI

Tapan Sarkar,

Sujan Sk, Ranjay K. Tiwari

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142073 - 142073

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the binding characteristics of bovine serum albumin with CDK4/6 inhibitors Ribociclib: Multi-spectral analysis and molecular simulation studies DOI
Shao‐Liang Jiang,

Wang-Cai Chen,

Yuting Wu

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 258, P. 112992 - 112992

Published: July 17, 2024

Language: Английский

Citations

3
Stabilizing effect of quercetin upon bovine serum albumin as a model protein DOI

Amit G. Rathod,

Priyanka Tiwari,

Jatin Shaily

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114663 - 114663

Published: March 1, 2025

Language: Английский

Citations

0
Tyrosinase inhibition, molecular docking and molecular dynamics simulation studies of anthraquinone derivative from aloe vera as potential pigmentation dermatosis and anti-food browning agent DOI

Zhu Wang,

Zhuo You,

Lu Chen

et al.

Spectroscopy Letters, Journal Year: 2024, Volume and Issue: 57(8), P. 452 - 468

Published: July 4, 2024

Language: Английский

Citations

2
Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (AsIII) and Methylarsenite (MAsIII) in Paddy Soil DOI
Lijuan Li, Jian Tian, Ke Huang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(17), P. 7469 - 7479

Published: April 1, 2024

Trivalent arsenicals such as arsenite (As

Language: Английский

Citations

1
Synthesis of Dimeric Indoles from Friedel–Crafts Reaction of Indoles with Ketones Catalysed by a Bronsted Acid Ionic Liquid and Their Interactions with BSA and DNA DOI
Sai Deepak Pasuparthy, Pranati Somkuwar, Venkatesan Kali

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(34), P. 14904 - 14923

Published: Jan. 1, 2024

The synthesis of 35 dimeric indole derivatives was carried out by using [BCMIM][Cl] ionic liquid as a catalyst. binding interaction between bovine serum albumin (BSA)/deoxyribonucleic acid (DNA) and synthesized compounds has been investigated.

Language: Английский

Citations

1
2-Benzimidazolamine-Acetamide Derivatives as Antibacterial Agents: Synthesis, ADMET, Molecular Docking, and Molecular Simulation Studies DOI

Nasreen Akhtar Mazumdar,

Afreen Inam,

Ayesha Akhtar

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract A series of 2-benzimidazolamine-acetamide derivatives were synthesized by substitution reaction different anilines with chloroacetyl chloride followed the 2-aminobenzimidazole formed substituted chloroacetamides. The structures all compounds elucidated various spectral techniques and evaluated against five bacterial strains. Out ten, N-(2-fluorophenyl)-substituted acetamide displayed better minimum inhibitory concentration (MIC). Disk diffusion assay combination studies also performed on same compound. Molecular docking this compound E. coli methionine aminopeptidase (METAP) effective binding, molecular dynamics simulation further suggested a stable complex formation. Thus, these results indicate that scaffolds can serve as model for developing antibacterial agents.

Language: Английский

Citations

1
Design and Development of 2-Benzimidazolamine - Acetamide Derivatives as Antibacterial Agents DOI

Ayesha Akhtar,

Asghar Ali, Kashish Azeem

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Comparative analysis of glimepiride interactions with bovine serum albumin and fibrinogen using fluorescence spectroscopy DOI Creative Commons

Apoorva Pathania,

Harman Deep Kour,

Monika Bhattu

et al.

E3S Web of Conferences, Journal Year: 2024, Volume and Issue: 588, P. 02017 - 02017

Published: Jan. 1, 2024

Bovine Serum Albumin (BSA) and Fibrinogen (Fib) are the model proteins extensively used for investigating drug-protein interactions due to their distinct binding characteristics structural similarities human serum albumin. The present report examines between Glimepiride (GM) [a sulfonylurea Type 2 Diabetes mellitus management) Fib And BSA, respectively. Fluorescence spectroscopy was employed analyze quenching mechanisms constants at 298 K 290 K, results indicate that GM binds BSA via hydrophobic forces, with rate showing significant interactions. constant ( k b ) interaction GM-Fib found be 1.297 × 10 4 Lmol -1 1.262× respectively Gibbs free energy (ΔG) equal -5.609 Kcal/mol, -3.627 Kcal/mol GM- determined 1.24 5 Lmol⁻¹ 9.896 3 K. ΔG associated these is -6.947 -5.302 thermodynamic parameters suggest spontaneous processes a negative value of ΔG. provide valuable insights into GM’s stability contributing understanding essential drug development.

Language: Английский

Citations

0