International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136874 - 136874
Published: Oct. 30, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 133083 - 133083
Published: June 12, 2024
Language: Английский
Citations
19
Luminescence, Journal Year: 2025, Volume and Issue: 40(1)
Published: Jan. 1, 2025
ABSTRACT Tetrachlorobisphenol A (TCBPA) is a kind of fire retardant extensively used in our life, but it can accumulate organisms and potentially have toxic effects. Transferrin (TF) glycoprotein predominantly present the blood plasma, serving as an essential mediator for transportation iron other small molecules. In study, various techniques including multi‐spectroscopic molecular docking were employed to examine interaction between TCBPA TF. The TF–TCBPA complex was formed with binding constant ( K ) 2.181 ± 0.035 × 10 4 M −1 at 298 K. Δ H S all negative, which means dominant driving forces van der Waals H‐bonds. secondary structure TF changed by TCBPA, resulting decline α‐helix structure, corresponding increase β‐sheet structure. revealed that positioned within pocket TF, engaged interactions some amino acid residues through different forces. Importantly, Tyr426/Asp392/His585 implies interferes ions vivo. All above results indicated adverse effects on activity should be more attention.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661
Published: March 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162676 - 162676
Published: April 1, 2025
Language: Английский
Citations
0
Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100667 - 100667
Published: April 22, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1594 - 1594
Published: Feb. 13, 2025
The aim of this study was to investigate the usefulness human embryonic kidney HEK293 cells as a model normal in biotin-mediated therapy. expression and role sodium multivitamin transporter (SMVT) uptake accumulation free biotin, well cationic neutral biotinylated PAMAM dendrimers fourth generation synthesized our laboratory, were assessed comparison other immortalized (HaCaT) cancer (HepG2, U-118 MG). obtained data showed that higher level SMVT not associated with stronger biotin dendrimers. Biotinylation increased selective an inversely proportional manner concentration used; however, lower than cell lines. time-dependent profiles differed significantly. Therefore, it should be assumed efficiency nanoparticles' depends on multiple cellular transport mechanisms. Toxicity tests significantly sensitivity conjugates for HepG2 HaCaT cells. Molecular modeling studies profile suggest only but also monocarboxylate 1 (MCT-1) may play important nanoparticles into Due complexity problem, further are necessary. In summary, can considered valuable biotin- targeted therapy using based
Language: Английский
Citations
0
The Analyst, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Carbon dots (CDs) are a type of carbon-based nanoparticle (NP) that have risen in popularity due to their unique tuneable physicochemical and optical properties.
Language: Английский
Citations
0
Advanced Optical Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Abstract Serendipitously discovered, carbon dots (CDs) have attracted significant attention as a potential contrast agent for photoacoustic imaging (PAI) in the biomedical sector. CDs play an essential role PAI, contributing significantly to early detection of diseases and monitoring treatment progress, particularly tumor imaging. This review emphasizes domain highlighting their characteristics like biocompatibility, enhanced spatial resolution, optical absorption NIR region, facile surface functionalization tumor‐ targeted The study explores use enhancing resolution PAI improved visualization tumors organs such breast, cervical, liver, gastrointestinal, skin, cardiovascular system, nervous others. Challenges associated with optimizing signal‐to‐noise ratio ensuring stability under physiological conditions, also been discussed.
Language: Английский
Citations
1
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Abstract Novel‐protein‐derived carbon dots have recently been reported with high biocompatibility, superior spatial resolution, photobleaching resistance, customizability, and no post‐synthesis conjugation requirement. These nanoparticles bring new capabilities in bioimaging targeted therapeutics. Protein‐based contain a core surface groups from the protein that can retain molecular recognition properties. In this work, systematic study of synthesis conditions to tune nanoparticle function is presented. Bovine serum albumin used as model simulate what parameter alterations yield valuable changes such red‐shifted photoluminescence, specific size distribution, chemistry functionalization. The dissociation constant, K D also calculated, for BSA‐derived NPs simulated 1:1 protein‐ligand binding at equilibrium. It found increased temperatures generally led higher quantum yields more CDs believed be due larger diameters, while nitrogen doping decreased. However, when using microwave radiation, are has 2.5–4.4% increase nitrogen, resulting most highest samples. Oven samples possessed 1.6–17.5x lower compared Understanding effects these parameters on CD characteristics enables scientists rationally design properties applications.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136874 - 136874
Published: Oct. 30, 2024
Language: Английский
Citations
0