Despite
widespread
interest
in
nanoscale
pillar
structures
for
various
optical
devices,
including
solar
cells,
photonic
crystal
lasers,
and
sensors,
the
critical
challenges
mass
production
are
high
equipment
costs
limited
scalability
of
traditional
manufacturing
methods.
To
overcome
these
hurdles,
this
study
develops
a
simple
highly
scalable
etch-mask
superposition
technique
based
on
thermally
assisted
nanotransfer
printing
(T-nTP)
Cr
line
patterns.
The
orthogonal
linear
mask
patterns
creates
double-height
cross-point
arrays
that
effectively
selectively
protect
underlying
SiO
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(1), P. 252 - 260
Published: Jan. 1, 2025
Explosive
analogues
(1-NN,
4-NP,
and
5-NI)
picric
acid
with
low
concentrations
(10
−4
–10
−7
M)
detected
on
SERS
substrates
consist
of
SiO
2
spheres
covered
Ag
layers
AgNPs.
ACS Applied Nano Materials,
Journal Year:
2025,
Volume and Issue:
8(4), P. 1903 - 1911
Published: Jan. 22, 2025
Surface-enhanced
Raman
spectroscopy
represents
a
highly
efficient
detection
method,
offering
significant
advantages
in
the
identification
and
of
target
analytes
food.
To
ensure
that
substrate
exhibits
high
sensitivity,
it
is
essential
to
facilitate
formation
stable
plasmonic
"hot
spot"
regions.
In
this
study,
gold
nanospheres
(Au
NSs)
were
synthesized
on
capillary
substrates
via
situ
growth
seed-mediated
method.
The
results
demonstrated
optimal
signal
enhancement
was
achieved
when
APTES
concentration
20%
diameter
Au
NSs
approximately
65
nm.
limits
fabricated
for
Rhodamine
6G
crystal
violet
probe
molecules
are
10–11
10–10
M,
respectively.
addition,
aspartame
can
be
detected
at
levels
as
low
0.0391
g/L,
which
significantly
below
national
standard.
result
demonstrates
has
excellent
uniformity,
stability
properties.
Therefore,
suitable
food
additive
with
promising
prospects
further
development.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Surface-enhanced
Raman
scattering
(SERS)
is
recognized
as
a
powerful
analytical
method.
However,
its
efficacy
hindered
by
considerable
signal
variability
stemming
from
factors
like
surface
irregularities,
temporal
instability
of
the
substrate,
interference
with
substrate
signal,
polarization
sensitivity
and
uneven
molecular
distribution.
To
address
these
challenges,
new
strategy
employed
to
enhance
reproducibility
SERS
signals.
Initially,
periodic
3D
metallic
structure
utilized
achieve
polarization-independent
ultrahigh
enhancement.
Additionally,
averaging
over
multiple
points
normalization
are
implemented.
The
integration
techniques
enables
multimodal
sensing
(SERS,
SEF,
SPR)
using
plasmonic
chip,
demonstrating
enhancement
through
interaction
extended
localized
plasmons
alongside
nanoantenna-type
resonances.
chip
comprises
silver
2D
grating
adorned
Au
nanocubes,
behaving
metasurface
amplify
local
fields,
thus
facilitating
SERS.
Its
uniformity
independence
together
mitigate
variability.
Fabricated
View,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
The
precise
fabrication
of
arrays
gold
and
silver
nanodots
(Au&Ag_NDs)
to
create
plasmonic
lattices
on
different
substrates
through
cost‐effective,
scalable
approaches
remains
challenging.
aim
this
research
is
engineer
a
new
class
hierarchical
based
Au&Ag_NDs
generated
polymer
via
template
replica‐assisted
nanoimprinting.
This
method
harnesses
combination
nanopatterning
anodization,
magnetron
sputtering,
annealing
generate
with
tunable
features
at
the
nanoscale.
These
are
explored
as
ultrasensitive
surface‐enhanced
Raman
scattering
(SERS)
platforms
for
detection
model
organic
(rhodamine
B
[RhB]).
reproducible
achieve
remarkable
enhancement
detect
RhB
molecules,
low
limit
10
−8
M.
field
factor
7
indicates
that
developed
adequate
efficient
highly
sensitive
SERS
detection.
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(4), P. 266 - 266
Published: Feb. 10, 2025
Exosome
detection
is
crucial
for
biomedical
research
and
clinical
diagnostics
due
to
their
unique
characteristics.
Surface-enhanced
Raman
spectroscopy
(SERS)
based
on
nanostructure
substrates
with
local
field
enhancement
capability
a
promising
approach.
However,
the
random
distribution
of
nanostructures
leads
uneven
"hotspots"
distribution,
which
limits
application
in
SERS
detection.
Here,
we
systematically
investigated
impact
experimental
parameters
morphology
analyzed
formation
mechanism,
achieving
controllable
nanocone
fabrication.
Subsequent
experiments
confirmed
reliability
effectiveness
fabricated
exosome
This
work
not
only
realized
flexible
control
but
also
expanded
prospects
analysis.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Clozapine
is
widely
regarded
as
one
of
the
most
effective
therapeutics
for
treatment-resistant
schizophrenia.
Despite
its
proven
efficacy,
therapeutic
use
clozapine
complicated
by
narrow
index,
which
necessitates
rapid
and
precise
drug
monitoring
(TDM)
to
optimize
patient
outcomes
minimize
adverse
effects.
However,
conventional
techniques,
such
high-performance
liquid
chromatography,
are
limited
their
high
costs,
complex
instrumentation,
long
turnaround
times.
Herein,
we
propose
a
novel
approach
that
integrates
artificial
neural
networks
(ANNs)
with
surface-enhanced
Raman
spectroscopy
(SERS)
on
plasmonic
metasurface
TDM
two
primary
metabolites,
norclozapine
clozapine-N-oxide,
in
human
serum.
The
ANN-SERS
strategy
enables
accurate
classification
robust
concentration
prediction
three
analytes.
We
envision
integrated
framework
could
deliver
scalable
biomedical
diagnostic
tool
studying
wide
variety
chemical
biological
molecules
clinical
settings.
