Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations DOI

Zeshan Ali Sandhu,

Muhammad Asam Raza, Umme Farwa

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: May 30, 2025

Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties. This review presents a comprehensive overview of recent developments in CDs within the context systems (DDSs) utilization carriers loading, stabilization, delivery. It also describes functionalized therapeutic applications, including cancer, antimicrobial, gene therapies. Key strategic issues such toxicity, biodistribution, manufacturability thoroughly elaborated critically evaluated identify novel approaches address crucial challenges. The promising potential transform current methods is driving researchers undertake further biological investigations regarding application clinical settings, well explore future prospects biomedical field.

Language: Английский

Blue Fluorescent Carbon Dots Doped with Nitrogen and Sulfur as a Dual-Functional Fluorescent Probe for the Detection of Hg2+ and Chloramphenicol DOI

Hongxiang Liu,

Shaogui Wu

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1329, P. 141459 - 141459

Published: Jan. 15, 2025

Language: Английский

Citations

3
Fluorescent carbon dots based on food wastes: Applications in food safety detection DOI
Chenghao Liu,

Yanqiu Mei,

Qiaowen Lei

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156434 - 156434

Published: Oct. 5, 2024

Language: Английский

Citations

10
A novel and high-performance tumor inhibitor of La, N co-doped carbon dots for U251 and LN229 cells DOI
Xinyun Ye,

Huanglian Zhong,

Lin Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114520 - 114520

Published: Jan. 14, 2025

Language: Английский

Citations

2
Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects DOI Creative Commons
Н. А. Печникова, Kalliopi Domvri, Κonstantinos Porpodis

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

ABSTRACT Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress utilizing CQDs for drug delivery, bioimaging, biosensing, cancer therapy. With unique optical properties, such as yield, photostability, enable precise bioimaging sensitive biosensing. Their small size, ease surface functionalization allow development targeted delivery systems, enhancing therapeutic precision minimizing side effects. In therapy, have shown photodynamic photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cells while sparing healthy tissues. Furthermore, CQDs’ ability penetrate biological barriers including blood–brain barrier opens new possibilities delivering agents hard‐to‐reach areas, tumors or diseased However, challenges optimizing synthesis, ensuring long‐term stability, addressing safety concerns environments remain critical hurdles. discusses current efforts overcome these improve CQD performance clinical settings, scalable production methods enhanced biocompatibility. As research progresses, are expected play an important role improving healthcare offering more treatment options contributing advancements personalized medicine.

Language: Английский

Citations

3
Biological Waste-Derived Carbon Dots and Their Applications DOI
Subhamoy Banerjee, Ruchira Mukherjee

Nanostructure science and technology, Journal Year: 2025, Volume and Issue: unknown, P. 107 - 128

Published: Jan. 1, 2025

Language: Английский

Citations

0
Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release DOI

Handa Liu,

Kexin An, Ning Qiao

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130699 - 130699

Published: March 1, 2025

Language: Английский

Citations

0
Carbon Dots as a Fluorescent Nanosystem for Crossing the Blood–Brain Barrier with Plausible Application in Neurological Diseases DOI Creative Commons
Catarina Araújo, Raquel O. Rodrigues, Manuel Bañobre‐López

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 477 - 477

Published: April 6, 2025

Background/Objectives: The development of effective therapies for brain disorders is highly correlated with the ability drugs or nanosystems to cross blood–brain barrier (BBB), which has been limited. Recently, carbon dots (CDs) have receiving attention be used as BBB-crossing theranostic agents due their inherent advantages, such low size, excellent biocompatibility, high quantum yield (QY), tunable fluorescence, drug loading, and relatively easy synthesis at cost. aim this study was design CDs precisely controlled fluorescence properties advanced bioimaging an in-depth assessment BBB permeability. Methods: were synthesized using a microwave-assisted approach, optimized through microwaves’ irradiation time, employing citric acid, urea, sodium fluoride precursors. sample labeled NF-CD. Results: A comprehensive physicochemical, photoluminescence, biological characterization revealed NF-CD diffuse across neuromimetic-BBB model, mainly small size (average diameter 4.0 ± 1.1 nm), exhibiting excitation-dependent in blue green wavelengths, biocompatibility QY, exceptional photostability. Conclusions: Owing characteristics compatibility, presents promising opportunities applications, particularly brain-targeted bioimaging, nanocarrier-based immunotherapy delivery, early-stage diagnostics, personalized medicine. NF-CD’s further underscores relevance pioneering nanomaterial-based strategies neurological disorder diagnostics precision-targeted therapeutic interventions. Overall, research contributes broader field nanotechnology-driven biomedical advancements, fostering innovations delivery systems.

Language: Английский

Citations

0
Carbon dots-based drug delivery for bone regeneration DOI Creative Commons
Congzhan Liu,

Yingzi Li,

Xiaohua Liu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 29, 2025

Carbon dots (CDs) are a class of nanobiomaterials with significant potential in bone regeneration. Their excellent biocompatibility, tunable fluorescence, high stability, low toxicity, and abundant functional groups make CDs promising candidates for efficient drug delivery tissue contribute to targeted release, enhance osteogenic differentiation, interact cellular components facilitate formation. Recent research highlights the roles scaffold-based approaches, offering controlled real-time bioimaging capabilities. This review provides comprehensive overview regeneration, focus on their synthesis, functionalization, biomedical applications. It begins by exploring CD synthesis methods, physicochemical properties, mechanisms action. Next, it discusses CD-based systems applications Finally, challenges future perspectives optimizing enhanced therapeutic outcomes.

Language: Английский

Citations

0
Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations DOI

Zeshan Ali Sandhu,

Muhammad Asam Raza, Umme Farwa

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: May 30, 2025

Carbon dots (CDs) are recognized as outstanding nanocarriers for drug delivery owing to their superior biocompatibility, straightforward synthetic routes, and tunable surface properties. This review presents a comprehensive overview of recent developments in CDs within the context systems (DDSs) utilization carriers loading, stabilization, delivery. It also describes functionalized therapeutic applications, including cancer, antimicrobial, gene therapies. Key strategic issues such toxicity, biodistribution, manufacturability thoroughly elaborated critically evaluated identify novel approaches address crucial challenges. The promising potential transform current methods is driving researchers undertake further biological investigations regarding application clinical settings, well explore future prospects biomedical field.

Language: Английский

Citations

0