ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 5068 - 5079

Published: June 28, 2024

External factors often lead to predictable damage, such as chemical injuries, burns, incisions, and wounds. Bacterial resistance antibiotics at wound sites underscores the importance of developing hydrogel composite systems with inorganic nanoparticles possessing antibacterial properties treat infected wounds expedite skin regeneration process. In this study, a promising TiO2-HAp@PF-127@CBM organic integrated system was designed address challenges associated bacterial healing. The synthesized TiO2-hydroxyapatite (HAp) nanocomposites were coated an FDA-approved PluronicF-127 polymer combined carbomer (CBM) accomplish final product. exhibit enhanced biocompatibility against L929 HUVECs cell proliferation effects. To mitigate oxidative stress caused by TiO2-induced reactive oxygen species in dark environments for effective effects, HAp promotes proliferation, expediting layer formation. CBM binds nanoparticles, facilitating their gradual release promoting reduced inflammation tissue observed group suggest favorable environment repair. These results align prior findings highlighting wound-healing titanium-HAp-based materials. ability dressing promote granulation formation facilitate epidermal its potential effects healing applications.

Language: Английский