Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties DOI Creative Commons

Reham E. Abdelwahab,

Ahmed H. M. Elwahy,

Nada S. Ibrahim

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 8, 2025

Abstract A ring annelation reaction was used to successfully prepare benzo[4,5]imidazo[1,2- a ][1,3,5]triazines (Systematic Name: 1,3,4a,9-tetraza-4 H -fluoren-2-amines) tethered phenoxy- N -arylacetamide, pyrazole, and 2-(4-(1-phenyl-1 -pyrazol-3-yl)phenoxy)- -arylacetamide moieties utilizing 1-(1 -benzo[ d ]imidazol-2-yl)guanidine the proper aldehydes as precursors. 2-(Phenylamino)ethyl fragment of compound 7 cleaved off 8 formed. The constitutions novel compounds were confirmed based on spectral data. antibacterial activity evaluated for prepared against two gram-negative gram-positive bacteria. Among them, 12b (inhibition zone 16 ± 0.7 mm) most promising S. aureus compared Gentamycin (15 0 mm). Also, 5a 5d exerted comparable zones 13 1.4 2.1 mm), respectively . Minimum inhibitory concentration (MIC) evaluation showed that had lowest MIC value (78.1 µg/mL).

Language: Английский

Synthesis, cytotoxic evaluation, and binding studies of novel Sulphamethoxazole-based Cyanoacrylamides as potential antitumor agents DOI Creative Commons

Fatma G. Mohamed,

Mohamed A. Ragheb, Ahmed H. M. Elwahy

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102119 - 102119

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties DOI Creative Commons

Reham E. Abdelwahab,

Ahmed H. M. Elwahy,

Nada S. Ibrahim

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 8, 2025

Abstract A ring annelation reaction was used to successfully prepare benzo[4,5]imidazo[1,2- a ][1,3,5]triazines (Systematic Name: 1,3,4a,9-tetraza-4 H -fluoren-2-amines) tethered phenoxy- N -arylacetamide, pyrazole, and 2-(4-(1-phenyl-1 -pyrazol-3-yl)phenoxy)- -arylacetamide moieties utilizing 1-(1 -benzo[ d ]imidazol-2-yl)guanidine the proper aldehydes as precursors. 2-(Phenylamino)ethyl fragment of compound 7 cleaved off 8 formed. The constitutions novel compounds were confirmed based on spectral data. antibacterial activity evaluated for prepared against two gram-negative gram-positive bacteria. Among them, 12b (inhibition zone 16 ± 0.7 mm) most promising S. aureus compared Gentamycin (15 0 mm). Also, 5a 5d exerted comparable zones 13 1.4 2.1 mm), respectively . Minimum inhibitory concentration (MIC) evaluation showed that had lowest MIC value (78.1 µg/mL).

Language: Английский

Citations

0