Molecular understanding of the self-assembly of an N-isopropylacrylamide delivery system for the loading and temperature-dependent release of curcumin DOI Creative Commons
Qijiang Shu,

Fuhua Yang,

Zedong Lin

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: July 29, 2024

Global changes and drug abuse are forcing humanity to face various disease problems, alternative therapies with safe natural substances have important research value. This paper combines techniques in quantum chemical calculations molecular simulations provide molecular-level insight into the dynamics of self-assembly N-isopropylacrylamide (NIPAM) for loading curcumin (CUR). The results indicate that increasing chain length NIPAM molecules reduces their efficiency encapsulating locking CUR, electrostatic interactions van der Waals main driving forces behind evolution system configurations these processes. isopropyl groups two phenolic ring planes CUR contact areas interaction between types molecules. thermosensitive effect can alter distribution around CUR. As a result, when temperature rises from ambient (300 K) human characteristic (310 K), NIPAM-CUR radial functions suggest body is more suitable release. Our findings offer vital theoretical foundation practical guidance researchers develop temperature-sensitive delivery systems tailored addressing its clinical application bottleneck. Curcumin substance beneficial pharmacological properties, but poor solubility, instability absorption hinder use as therapeutic agent body. Here, authors explore release curcumin.

Language: Английский

Enhancing biocompatibility and functionality: Carbon nanotube-polymer nanocomposites for improved biomedical applications DOI

M. Maghimaa,

Suresh Sagadevan,

E Boojhana

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105958 - 105958

Published: July 9, 2024

Language: Английский

Citations

15
A Mechanistic Understanding to Photophysical Phenomenon in Development of Near-Infrared (NIR) Responsive Hydrogels: Advancements in precision Drug Delivery DOI
Tejasvi Pandey, Vivek Pandey

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106682 - 106682

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in sensing technologies using functional carbon nanotube-hydrogel nanocomposites DOI
Mansour A.S. Salem,

Aadil Shafi Bhat,

Rabiya Mehandi

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114139 - 114139

Published: Feb. 1, 2025

Language: Английский

Citations

0
Design and characterization of tunable chitosan hydrogels cross-linked with epiclon through amide bond formation modified with multi-walled carbon nanotubes for adsorption of aflatoxin B 1 from aqueous solutions DOI
Ali Reza Karimi,

Sahand Fateh,

Fahimeh Bayat

et al.

Journal of Macromolecular Science Part A, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 24, 2025

Language: Английский

Citations

0
Design and Application of Stimuli‐Responsive Nanocomposite Hydrogels: A Review DOI Open Access
Xiaohan Guo, Huan Liu,

Aminov Nail

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract In order to improve the disadvantages of traditional hydrogels such as low mechanical strength and lack responsiveness, different types nanoparticles or nanostructures are added into hydrogel network through in situ polymerization, self‐assembly techniques, other strategies, giving a variety special properties, stimulation sensitivity, optical electrical reversibility. With development nano materials synthesis technology, nanocomposite have shown great potential drug delivery, tissue engineering, motion detection, wastewater treatment, been extensively studied recent years. This review comprehensively elucidates state‐of‐the‐art preparation strategies underlying response mechanisms diverse stimulus‐responsive hydrogels, spanning temperature, pH, humidity, electrical, light responses. It systematically dissects their applications biomedicine, environmental remediation, flexible sensing, composite phase change materials. Moreover, it delves future prospects challenges, emphasizing need for continuous innovation unlock full emerging fields address existing limitations.

Language: Английский

Citations

0
Polycaprolactone-Based Composite Electrospun Nanofibers as Hybrid Biomaterial Systems Containing Hydroxyl- or Carboxylic Acid-Functionalized Multiwall Carbon Nanotubes DOI Creative Commons
Y. Emre Bulbul, Nursel Dilsiz

Fibers and Polymers, Journal Year: 2024, Volume and Issue: 25(5), P. 1701 - 1712

Published: April 20, 2024

Abstract Composite electrospun nanofibers based on polycaprolactone (PCL) have shown promise in various biomedical applications due to their unique properties. This study investigates the effects of incorporating hydroxyl (–OH)- or carboxylic acid (–COOH)-functionalized multiwall carbon nanotubes (MWCNTs) into PCL matrices. Two types functionalized additives, MWCNT-OH and MWCNT-COOH, were used at different concentrations (0.06 0.12 wt%). Various characterization techniques including FTIR, XRD, AFM, SEM, water contact angle analysis, tensile strength testing employed evaluate changes nanofiber morphology, crystallinity, surface topography, wettability, mechanical In addition, vitro cytotoxicity assays conducted using HUVECs L929 fibroblasts over 1-, 3-, 5-day intervals. represents a novel examination MWCNTs as additives biopolymer The findings indicate that small amounts enhances physicochemical characteristics nanofibers, making them more suitable for applications. While both MWCNT improved properties compared pure MWCNT-incorporated exhibited most favorable features. conclusion, this research highlights potential tailored PCL-based composite containing advanced biomaterial systems applications, contributing development innovative biomaterials diverse contexts.

Language: Английский

Citations

1
Molecular understanding of the self-assembly of an N-isopropylacrylamide delivery system for the loading and temperature-dependent release of curcumin DOI Creative Commons
Qijiang Shu,

Fuhua Yang,

Zedong Lin

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: July 29, 2024

Global changes and drug abuse are forcing humanity to face various disease problems, alternative therapies with safe natural substances have important research value. This paper combines techniques in quantum chemical calculations molecular simulations provide molecular-level insight into the dynamics of self-assembly N-isopropylacrylamide (NIPAM) for loading curcumin (CUR). The results indicate that increasing chain length NIPAM molecules reduces their efficiency encapsulating locking CUR, electrostatic interactions van der Waals main driving forces behind evolution system configurations these processes. isopropyl groups two phenolic ring planes CUR contact areas interaction between types molecules. thermosensitive effect can alter distribution around CUR. As a result, when temperature rises from ambient (300 K) human characteristic (310 K), NIPAM-CUR radial functions suggest body is more suitable release. Our findings offer vital theoretical foundation practical guidance researchers develop temperature-sensitive delivery systems tailored addressing its clinical application bottleneck. Curcumin substance beneficial pharmacological properties, but poor solubility, instability absorption hinder use as therapeutic agent body. Here, authors explore release curcumin.

Language: Английский

Citations

0