Photoisomerization Dynamics of Azo-Escitalopram Using Surface Hopping and a Semiempirical Method DOI Creative Commons
Hans Georg Gallmetzer, Eduarda Sangiogo Gil, Leticia González

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

The photoisomerization dynamics of azo-escitalopram, a synthetic photoswitchable inhibitor the human serotonin transporter, is investigated in both gas-phase and water. We use trajectory surface hopping method─as implemented SHARC─interfaced with floating occupation molecular orbital-configuration interaction semiempirical method to calculate on-the-fly energies, forces, couplings. inclusion explicit water molecules enabled using an electrostatic quantum mechanics/molecular mechanics framework. find that yield trans-azo-escitalopram wavelength- environment-dependent,

Language: Английский

The Role of Double Excitations in Exciton Dynamics of Multiazobenzenes: Trisazobenzenophane as a Test Case DOI Creative Commons
Evgenii Titov

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(29), P. 7482 - 7488

Published: July 16, 2024

Molecular exciton dynamics underlie energy and charge transfer processes in organic multichromophoric systems. A particularly interesting class of the latter is multiphotochromic systems made molecules capable photochemical transformations. Exciton assemblies photoswitches have been recently investigated using either molecular model or supermolecular configuration interaction (CI) singles, both approaches being based on a semiempirical Hamiltonian combined with surface hopping dynamics. Here, we study how inclusion double excitations nonadiabatic simulations affects multiazobenzenes, trisazobenzenophane as an example. We find that CI singles doubles yield virtually same time scale dynamical localization, ∼50 fs for studied multiazobenzene. However, considerably excited state lifetimes isomerization quantum yields.

Language: Английский

Citations

0

Photoisomerization Dynamics of Azo-Escitalopram Using Surface Hopping and a Semiempirical Method DOI Creative Commons
Hans Georg Gallmetzer, Eduarda Sangiogo Gil, Leticia González

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

The photoisomerization dynamics of azo-escitalopram, a synthetic photoswitchable inhibitor the human serotonin transporter, is investigated in both gas-phase and water. We use trajectory surface hopping method─as implemented SHARC─interfaced with floating occupation molecular orbital-configuration interaction semiempirical method to calculate on-the-fly energies, forces, couplings. inclusion explicit water molecules enabled using an electrostatic quantum mechanics/molecular mechanics framework. find that yield trans-azo-escitalopram wavelength- environment-dependent,

Language: Английский

Citations

0