Single‐Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing DOI Creative Commons
Weijie Xu,

Qiuru Huang,

Yujuan Qi

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Testicular ageing is accompanied by a series of morphological changes, while the features mitochondrial dysfunction remain largely unknown. Herein, we observed range age‐related modifications in testicular morphology and spermatogenic cells, conducted single‐cell RNA sequencing on young old testes Drosophila . Pseudotime trajectory revealed significant changes germline subpopulations during ageing. Our examination unveiled that genes showing bias spermatids exhibited higher dN/dS than those GSCs_Spermatogonia. Genes biased towards GSCs_Spermatogonia displayed Interestingly, demonstrated lower contrast to spermatids, revealing complexity evolutionary adaptations Furthermore, mitochondria associated events, including oxidative phosphorylation, TCA cycle pyruvate metabolism, were significantly enriched subpopulations. Specifically, function was impaired process ageing, concurrently emphasising role several key nuclear genome‐encoded regulatory genes, such as Hsp60B, fzo, Tim17b1 mRpL12. data offer insights into homeostasis regulated process.

Language: Английский

Design, synthesis and biological evaluation of novel naphthoquinothiazole derivatives as potent antitumor agents through inhibiting STAT3 DOI

Dongmei Fan,

Pingxian Liu,

Z.-Q. Li

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107565 - 107565

Published: June 15, 2024

Language: Английский

Citations

2
Single‐Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing DOI Creative Commons
Weijie Xu,

Qiuru Huang,

Yujuan Qi

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Testicular ageing is accompanied by a series of morphological changes, while the features mitochondrial dysfunction remain largely unknown. Herein, we observed range age‐related modifications in testicular morphology and spermatogenic cells, conducted single‐cell RNA sequencing on young old testes Drosophila . Pseudotime trajectory revealed significant changes germline subpopulations during ageing. Our examination unveiled that genes showing bias spermatids exhibited higher dN/dS than those GSCs_Spermatogonia. Genes biased towards GSCs_Spermatogonia displayed Interestingly, demonstrated lower contrast to spermatids, revealing complexity evolutionary adaptations Furthermore, mitochondria associated events, including oxidative phosphorylation, TCA cycle pyruvate metabolism, were significantly enriched subpopulations. Specifically, function was impaired process ageing, concurrently emphasising role several key nuclear genome‐encoded regulatory genes, such as Hsp60B, fzo, Tim17b1 mRpL12. data offer insights into homeostasis regulated process.

Language: Английский

Citations

1