Zinc from an Essential Element to an Antiparasitic Therapeutic Agent
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Tropical
parasitic
diseases
affect
millions
of
people
around
the
world,
particularly
in
poor
countries.
The
human
that
will
be
covered
this
review
are
malaria
and
neglected
diseases,
such
as
leishmaniasis,
Chagas
disease,
African
trypanosomiasis.
current
treatments
for
these
present
several
problems,
development
drug
resistance,
very
limited
drugs
available
clinic,
significant
side
effects
drugs,
a
long
treatment
period.
For
reasons,
there
is
an
urgent
need
to
develop
new
chemotherapeutics
eradicate
or
eliminate
diseases.
Zinc-based
against
could
alternative
therapy
overcome
difficulties
approved
metallodrugs
antiparasitic
agents.
becoming
exciting
field
research
because
zinc
essential
element
can
lead
multitarget
agents,
which
reviewed
here.
Language: Английский
Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers
Chemical Research in Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Despite
the
popularity
of
electronic
cigarettes
(e-cigs)
among
adolescent
and
youth
never-smokers
adult
smokers
seeking
a
less
harmful
substitute
for
tobacco
cigarettes,
long-term
health
impact
vaping
is
largely
unknown.
Biochemical,
molecular,
toxicological
analyses
biospecimens
from
e-cig
users
as
well
assays
in
relevant
vitro
models
silico
studies
can
identify
chemical
constituents
emissions
that
may
contribute
to
disease-causing
potential
vaping.
E-cig
aerosol
contains
wide
range
toxic
carcinogenic
compounds,
which
metals
are
particular
concern.
This
due
known
or
suspected
role
various
pathogenesis
numerous
diseases.
Many
metalloids
(herein
referred
"metals")
have
been
detected
liquid
(e-liquid)
and/or
cells,
tissues,
biofluids,
other
specimens
users.
Metals
contaminate
ingredients
e-liquid
corrode
internal
components
device.
also
be
directly
aerosolized
surface
heating
element
parts
Inhalation
metal
habitual
vapers
nonusers
through
secondary
exposure
increase
body
burden
chemicals.
review
summarizes
state
research
on
e-cig-derived
their
contributions
estimated
risks
Highlighting
composition
aerosol,
it
focuses
contents
inhaled
associated
with
this
exposure.
Emphasis
placed
adolescents
who
vulnerable
populations
bear
disproportionate
risk
harm
products.
The
gaps
knowledge,
methodological
challenges,
opportunities
ahead
discussed.
importance
translating
findings
into
actionable
information
used
regulation
manufacturing
products
underscored.
Language: Английский
Comprehensive assessment of matrix effects in metallomics: evaluating 27 metals in serum, heparine-plasma-, EDTA-plasma and citrate-plasma by ICP-MS analysis
Journal of Trace Elements in Medicine and Biology,
Journal Year:
2025,
Volume and Issue:
89, P. 127667 - 127667
Published: May 1, 2025
Language: Английский
Gold complexes: a new frontier in the battle against lung cancer
Reviews in Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Abstract
Lung
cancer
is
the
second
leading
cause
of
mortality
related
to
cancer.
So,
it
very
necessary
explore
novel
strategies
eradicate
it.
Currently,
gold
based
medicinal
compounds
have
emerged
as
remarkable
anticancer
agents
and
expressed
strong
potential
against
lung
cell
lines.
This
review
provides
a
comprehensive
overview
history,
advancements,
recent
state
complexes
in
treatment
We
discuss
biological
evaluation
relation
with
chemical
structures
numerous
complexes,
including
those
featuring
thiosemicarbazone,
N
-heterocyclic
imine,
carbenes,
steroidyl
NHC,
CAACs,
carbamates,
diphosphanes
ligands.
Gold
complexes’
cytotoxicity
has
been
assessed
contrasted
that
standard
drugs
such
auranofin
cisplatin,
special
focus
on
IC
50
values
for
evaluating
potency.
targets
deliver
detailed
understanding
therapies,
paving
way
future
research
clinical
applications.
Language: Английский