
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 17, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 17, 2024
Language: Английский
Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Language: Английский
Citations
2Green Chemical Engineering, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
4Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 83 - 103
Published: Jan. 1, 2025
Language: Английский
Citations
0Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
0Ankara Universitesi Eczacilik Fakultesi Dergisi, Journal Year: 2025, Volume and Issue: 49(2), P. 14 - 14
Published: May 4, 2025
Objective: Phase II detoxification enzymes called Glutathione S-Transferases (GSTs) protect our bodies from the harmful effects of xenobiotics. The GSTP1 isoenzyme not only detoxifies toxic substances but also contributes to cancer treatment resistance. earliest and most potent GST inhibitor is ethacrynic acid (EA). This work compares graphene quantum dots (GQDs) with EA that has been shown be beneficial in anticancer investigations, using molecular docking analysis order offer idea a possible GSTP1. Material Method: density functional theory (DFT) method was applied theoretical calculations on GQDs compound Gaussview 5.0 software. application Gaussian 09 used refine geometry. Calculations electrostatic potential (MEP) were identify compounds' reactive sites. PyRx Tools AutoDock Vina software conduct studies between optimized molecule receptor-ligand interactions visualized Discover Studio Visualizer 4.0. Result Discussion: found interact H Site residues GSTP1, as EA. However, their electrophilicity much lower than We think they can inhibitors by increasing surface modifications.
Language: Английский
Citations
0Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101348 - 101348
Published: Sept. 26, 2024
Language: Английский
Citations
1Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 17, 2024
Language: Английский
Citations
0