A Quantum Chemical, Biological, and Experimental Analysis of Newly Synthesized Schiff-based PEI CA/N-GQDs Nanomaterials: Evaluation of Anticancer Potential in Human Neuroblastoma Cell DOI Creative Commons
Murat Kılıç, Buket Altınok Güneş, Omer Faruk Kırlangıç

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well theoretically DFT method. addition to their biological activities, cytotoxic, apoptotic cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According UV-Vis data, observed that exhibits phenol-imine/keto-amine tautomerism, phenomenon common 2-hydroxy bases help explain various properties material. Furthermore, predominantly exists keto-amine form. demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed binds DNA through an electrostatic interaction causes oxidative hydrolytic cleavage DNA, which results increase ROS cell, activation CASPASE-3, leading cells undergo apoptosis, inhibiting division G1/S phase. believe chemical Schiff-based PEI N-GQDs make them superior carrier molecule cancer treatment. Furthermore anticancer PEI-CA/N-GQDs suggest potential therapeutic agent neuroblastoma.

Language: Английский

CO2 Adsorption Using Graphene-Based Materials: A Review DOI
Ridhwan Lawal, Mohammad M. Hossain

Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

2

CO2 capture and conversion using graphene-based materials: a review on recent progresses and future outlooks DOI Creative Commons
Mutawakkil Isah, Ridhwan Lawal, Sagheer A. Onaizi

et al.

Green Chemical Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4

Progress in thermoplastic/thermoset polymeric nanocomposites reinforced with graphene quantum dots DOI
Ayesha Kausar

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 83 - 103

Published: Jan. 1, 2025

Language: Английский

Citations

0

A comprehensive investigation of PtNPs/PEI N-GQDs nanocomposite: DFT modeling, anticancer activity, and biosensing applications DOI Creative Commons
Buket Altınok Güneş, Omer Faruk Kırlangıç, Murat Kılıç

et al.

Journal of Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0

GRAPHENE QUANTUM DOTS AND ITS DERIVATIVES AS A POTENTIAL INHIBITOR OF GLUTATHIONE S-TRANSFERASE PI-1 ISOENZYME: A COMPUTATIONAL STUDY DOI Open Access
Murat Kılıç, Bahadır Boyacıoğlu

Ankara Universitesi Eczacilik Fakultesi Dergisi, Journal Year: 2025, Volume and Issue: 49(2), P. 14 - 14

Published: May 4, 2025

Objective: Phase II detoxification enzymes called Glutathione S-Transferases (GSTs) protect our bodies from the harmful effects of xenobiotics. The GSTP1 isoenzyme not only detoxifies toxic substances but also contributes to cancer treatment resistance. earliest and most potent GST inhibitor is ethacrynic acid (EA). This work compares graphene quantum dots (GQDs) with EA that has been shown be beneficial in anticancer investigations, using molecular docking analysis order offer idea a possible GSTP1. Material Method: density functional theory (DFT) method was applied theoretical calculations on GQDs compound Gaussview 5.0 software. application Gaussian 09 used refine geometry. Calculations electrostatic potential (MEP) were identify compounds' reactive sites. PyRx Tools AutoDock Vina software conduct studies between optimized molecule receptor-ligand interactions visualized Discover Studio Visualizer 4.0. Result Discussion: found interact H Site residues GSTP1, as EA. However, their electrophilicity much lower than We think they can inhibitors by increasing surface modifications.

Language: Английский

Citations

0

Anti-cancer activity and optoelectronic properties via DFT calculations of rare-earth dually doped wurtzite-type ZnO nano-systems DOI
Y. Slimani, S. Çalışkan, Firdos Alam Khan

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101348 - 101348

Published: Sept. 26, 2024

Language: Английский

Citations

1

A Quantum Chemical, Biological, and Experimental Analysis of Newly Synthesized Schiff-based PEI CA/N-GQDs Nanomaterials: Evaluation of Anticancer Potential in Human Neuroblastoma Cell DOI Creative Commons
Murat Kılıç, Buket Altınok Güneş, Omer Faruk Kırlangıç

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract In this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well theoretically DFT method. addition to their biological activities, cytotoxic, apoptotic cell cycle arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According UV-Vis data, observed that exhibits phenol-imine/keto-amine tautomerism, phenomenon common 2-hydroxy bases help explain various properties material. Furthermore, predominantly exists keto-amine form. demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed binds DNA through an electrostatic interaction causes oxidative hydrolytic cleavage DNA, which results increase ROS cell, activation CASPASE-3, leading cells undergo apoptosis, inhibiting division G1/S phase. believe chemical Schiff-based PEI N-GQDs make them superior carrier molecule cancer treatment. Furthermore anticancer PEI-CA/N-GQDs suggest potential therapeutic agent neuroblastoma.

Language: Английский

Citations

0