Gold Nanostar‐Decorated Electrospun Nanofibers Enable On‐Demand Drug Delivery DOI Open Access
Mohammad Ali Haghighat Bayan, Alicja Kosik‐Kozioł, Zuzanna J. Krysiak

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract This study explores the development of a photo‐responsive bicomponent electrospun platform and its drug delivery capabilities. is composed two polymers poly(lactide‐ co ‐glycolide) (PLGA) poly(3‐hydroxybutyrate‐ ‐3‐hydroxyvalerate) (PHBV). Then, decorated with plasmonic gold nanostars (Au NSs) that are capable on‐demand release. Using Rhodamine‐B (RhB) as model drug, release behavior bi‐polymer system compared versus homopolymer fibers. The RhB incorporated in PHBV part platform, which provides more sustained release, both absence presence near‐infrared (NIR) irradiation. Under NIR exposure, thermal imaging reveals notable increase surface temperature, facilitating enhanced Furthermore, demonstrates upon multiple irradiation cycles. offers promising approach for stimuli‐responsive delivery, making it strong candidate therapy applications.

Language: Английский

Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance DOI Creative Commons
Mahbubur Rahman,

Mohashin Kabir,

Tarikul Islam

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by rapid degradation, limited bioavailability, poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area tunable pore size, designed used as cur delivery carrier to overcome these limitations. The synthesis of cur-loaded ZIF-8 involves solvothermal method, followed encapsulation within the porous structure ZIF-8. amount was varied synthesize series panel 0.5 mg/mL cur@ZIF-8 that showed higher drug loading efficiency (85.91 ± 1.26%) capability (12.93 0.19%) without changes in shape, crystallinity, chemical composition, thermal stability original exhibited (1591.02 m2/g) micropore volume (0.54 cm3/g). Cur@ZIF-8 demonstrated superior outstanding antibacterial achieving 99% compared free cur. It less cytotoxicity against human fibroblast cells better antioxidant properties than Furthermore, release rate under acidic conditions, which promotes wound healing due microenvironment skin. biocompatibility nanoparticles highlight their potential promising candidates for diverse applications.

Language: Английский

Citations

5
Gold Nanostar‐Decorated Electrospun Nanofibers Enable On‐Demand Drug Delivery DOI Open Access
Mohammad Ali Haghighat Bayan, Alicja Kosik‐Kozioł, Zuzanna J. Krysiak

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract This study explores the development of a photo‐responsive bicomponent electrospun platform and its drug delivery capabilities. is composed two polymers poly(lactide‐ co ‐glycolide) (PLGA) poly(3‐hydroxybutyrate‐ ‐3‐hydroxyvalerate) (PHBV). Then, decorated with plasmonic gold nanostars (Au NSs) that are capable on‐demand release. Using Rhodamine‐B (RhB) as model drug, release behavior bi‐polymer system compared versus homopolymer fibers. The RhB incorporated in PHBV part platform, which provides more sustained release, both absence presence near‐infrared (NIR) irradiation. Under NIR exposure, thermal imaging reveals notable increase surface temperature, facilitating enhanced Furthermore, demonstrates upon multiple irradiation cycles. offers promising approach for stimuli‐responsive delivery, making it strong candidate therapy applications.

Language: Английский

Citations

0