Role of vitamin D3 in mitigating sodium arsenite-induced neurotoxicity in male rats DOI
Heba M. Abdou, Abeer Saad, Heba‐Tallah Abd Elrahim Abd Elkader

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)

Published: Nov. 5, 2024

Abstract Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the protective effects of vitamin D3 (Vit. D3) in countering oxidative stress, neuroinflammation apoptosis induced by sodium arsenite (SA) cerebral cortex rats. Male Wistar rats were subjected to a daily oral administration (NaAsO2, SA) at dosage 5 mg/kg, along 500 IU/kg Vit. D3, combination both substances for four weeks. results indicated that effectively mitigated SA-induced increase stress markers, thiobarbituric acid reactive (TBARS) nitric oxide (NO), decrease antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, glutathione peroxidase; GPx), as well pro-inflammatory markers including, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), amyloid-beta (Aβ)1–42. Furthermore, reversed alterations neurochemicals acetylcholinesterase (AchE), monoamine oxidase (MAO), dopamine (DA), acetylcholine (Ach) ameliorated histopathological changes cortex. Moreover, immunohistochemical analyses revealed reduced overexpression cysteine aspartate-specific protease-3 (caspase-3) glial fibrillary acidic protein (GFAP) male Consequently, co-administration can protect against neurotoxicity, primarily through its antioxidant, anti-inflammatory, anti-apoptotic, anti-astrogliosis effects.

Language: Английский

The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications DOI Open Access
Giuseppe Merra,

Giada La Placa,

Marcello Covino

et al.

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

Citations

0
Neurotoxic effects of aluminum and manganese: From molecular to clinical effects DOI
Н.В. Зайцева,

М.А. Zemlyanova,

A B Gekht

et al.

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123480 - 123480

Published: April 1, 2025

Language: Английский

Citations

0
Fisetin attenuates AlCl3-induced neurodegeneration by modulating oxidative stress and inflammatory cytokine release in adult albino wistar rats. DOI Creative Commons

E. G.,

Justus Nmaduka Nwachukwu,

Rahul Rajan R.S

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101812 - 101812

Published: Nov. 13, 2024

Language: Английский

Citations

2
Role of vitamin D3 in mitigating sodium arsenite-induced neurotoxicity in male rats DOI
Heba M. Abdou, Abeer Saad, Heba‐Tallah Abd Elrahim Abd Elkader

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(6)

Published: Nov. 5, 2024

Abstract Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the protective effects of vitamin D3 (Vit. D3) in countering oxidative stress, neuroinflammation apoptosis induced by sodium arsenite (SA) cerebral cortex rats. Male Wistar rats were subjected to a daily oral administration (NaAsO2, SA) at dosage 5 mg/kg, along 500 IU/kg Vit. D3, combination both substances for four weeks. results indicated that effectively mitigated SA-induced increase stress markers, thiobarbituric acid reactive (TBARS) nitric oxide (NO), decrease antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, glutathione peroxidase; GPx), as well pro-inflammatory markers including, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), amyloid-beta (Aβ)1–42. Furthermore, reversed alterations neurochemicals acetylcholinesterase (AchE), monoamine oxidase (MAO), dopamine (DA), acetylcholine (Ach) ameliorated histopathological changes cortex. Moreover, immunohistochemical analyses revealed reduced overexpression cysteine aspartate-specific protease-3 (caspase-3) glial fibrillary acidic protein (GFAP) male Consequently, co-administration can protect against neurotoxicity, primarily through its antioxidant, anti-inflammatory, anti-apoptotic, anti-astrogliosis effects.

Language: Английский

Citations

1