The highs and lows of monoamine oxidase as molecular target in cancer: an updated review DOI Creative Commons
Iasmina M. Hâncu,

Silvia Giuchici,

Adina V. Furdui-Lința

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The global burden of cancer as a major cause death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A MAO-B, are mammalian mitochondrial enzymes responsible for oxidative deamination neurotransmitters amines central nervous system peripheral tissues constant generation hydrogen peroxide main deleterious ancillary product. However, given complexity biology, MAO involvement tumorigenesis is multifaceted different tumors displaying either an increased or decreased profile. inhibitors currently approved treatment neurodegenerative diseases (mainly, Parkinson’s disease) secondary/adjunctive therapeutic options depression. Herein, we review literature characterizing MAO’s putative role several malignancies, also provide perspectives regarding potential biomarker that could play future oncology.

Language: Английский

The highs and lows of monoamine oxidase as molecular target in cancer: an updated review DOI Creative Commons
Iasmina M. Hâncu,

Silvia Giuchici,

Adina V. Furdui-Lința

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The global burden of cancer as a major cause death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A MAO-B, are mammalian mitochondrial enzymes responsible for oxidative deamination neurotransmitters amines central nervous system peripheral tissues constant generation hydrogen peroxide main deleterious ancillary product. However, given complexity biology, MAO involvement tumorigenesis is multifaceted different tumors displaying either an increased or decreased profile. inhibitors currently approved treatment neurodegenerative diseases (mainly, Parkinson’s disease) secondary/adjunctive therapeutic options depression. Herein, we review literature characterizing MAO’s putative role several malignancies, also provide perspectives regarding potential biomarker that could play future oncology.

Language: Английский

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