Four-Dimensional Printing of β-Tricalcium Phosphate-Modified Shape Memory Polymers for Bone Scaffolds in Osteochondral Regeneration
Materials,
Journal Year:
2025,
Volume and Issue:
18(2), P. 306 - 306
Published: Jan. 11, 2025
The
use
of
scaffolds
for
osteochondral
tissue
regeneration
requires
an
appropriate
selection
materials
and
manufacturing
techniques
that
provide
the
basis
supporting
both
cartilage
bone
formation.
As
are
designed
to
replicate
a
part
replaced
ensure
cell
growth
differentiation,
implantable
have
meet
various
biological
requirements,
e.g.,
biocompatibility,
biodegradability,
mechanical
properties.
Osteoconductive
such
as
tricalcium
phosphate
ceramics
some
biodegradable
polymers
appear
be
perfect
choice.
present
work
evaluates
structural,
mechanical,
thermal,
functional
properties
shape
memory
terpolymer
modified
with
β-tricalcium
(β-TCP).
A
new
approach
is
using
developed
4D
printing,
particular
focus
on
its
applicability
in
medical
implants.
In
this
study,
parameters
scaffold
components
were
developed.
examined
via
scanning
electron
microscopy
energy
dispersive
spectroscopy
(SEM-EDS),
Fourier-transform
infrared
(FTIR),
differential
calorimetry
(DSC),
testing.
cytotoxicity
result
was
obtained
MTT
assay,
alkaline
phosphatase
(ALP)
activity
measured.
structural
microstructural
investigations
confirmed
integration
β-TCP
into
filament
matrix
scaffolds.
Thermal
stability
enhanced
delayed
depolymerization
polymer
matrix.
studies
demonstrated
effective
recovery.
vitro
culture
revealed
significantly
increased
viability
β-TCP-modified
after
3
weeks.
can
tailored
applications
which
partial
recovery
acceptable,
Language: Английский
3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair
Materials,
Journal Year:
2025,
Volume and Issue:
18(8), P. 1826 - 1826
Published: April 16, 2025
A
novel
bi-layered
scaffold,
obtained
via
3D
printing
and
electrospinning,
was
designed
to
improve
osteochondral
region
reconstruction.
The
upper
electrospun
membrane
will
act
as
a
barrier
against
unwanted
tissue
infiltration,
while
the
lower
3D-printed
layer
provide
porous
structure
for
ingrowth.
Graphene
integrated
into
scaffold
its
antibacterial
properties,
drug
Osteogenon®
(OST)
added
promote
bone
regeneration.
composite
scaffolds
were
subjected
comprehensive
physical,
thermal,
mechanical
evaluations.
Additionally,
their
biological
functionality
assessed
by
means
of
NHAC-kn
cells.
0.5%
graphene
addition
PCL
significantly
increased
strain
at
break,
enhancing
material
ductility.
GNP
also
acted
an
effective
nucleating
agent,
raising
crystallization
temperatures
supporting
mineralization.
high
surface
area
facilitated
rapid
apatite
formation
attracting
calcium
phosphate
ions.
This
confirmed
FTIR,
µCT
SEM
analyses,
which
highlighted
positive
impact
on
mineral
deposition.
synergistic
interaction
between
nanoplatelets
created
bioactive
environment
that
enhanced
cell
adhesion
proliferation,
promoted
superior
formation.
These
findings
highlight
scaffold’s
potential
promising
biomaterial
repair
regenerative
medicine.
Language: Английский