Polydopamine-functionalized acellular fish scale scaffolds for accelerated bone tissue regeneration DOI Creative Commons
Shilong Su, Ruideng Wang, Jinwu Bai

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(18), P. 13857 - 13873

Published: Jan. 1, 2025

The complex microenvironment changes in the bone defect site are main reason for its refractory treatment, including significant increase level of reactive oxygen species (ROS) and inflammatory dysregulation. There is an urgent need to develop some bioactive materials that can regulate promote regeneration. This study proposed a new strategy designing tissue engineering scaffolds based on fish scales developed polydopamine-functionalized acellular scale scaffold (PDA-AFS). results showed PDA-AFS had excellent mechanical properties, special three-dimensional surface topography, biodegradability. In vitro good biocompatibility cell adhesion ability, could effectively reduce ROS levels, immunomodulatory activity. More importantly, enhance osteogenic differentiation marrow mesenchymal stem cells endogenous regeneration critical-sized calvarial defects. addition, transcriptome analysis also provided clues possible mechanism. Overall, we provide treatment

Language: Английский

A novel strategy for bone defect repair: Stromal cell-derived factor 1α sustained-release acellular fish scale scaffolds combined with injection of bone marrow mesenchymal stem cells promote bone regeneration DOI Creative Commons
Shilong Su, Jinwu Bai, Ruideng Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101759 - 101759

Published: April 1, 2025

Patients with bone defects often have weak cell vitality and differentiation ability of endogenous marrow mesenchymal stem cells (BMSCs), which makes regeneration face challenges. At present, the tissue engineering strategies are mainly to build grafts by loading on scaffolds in vitro. These many difficulties that limit their clinical application. To this end, we developed a new strategy for defect repair, namely chemotactic cell-free combined BMSCs injection. We first prepared polydopamine-functionalized acellular fish scale scaffold can continuously release stromal cell-derived factor 1α (SDF-1α) (termed as SDF-1α/PAFS) vivo at least 10 days. The study results showed not only has excellent mechanical properties good biocompatibility but also reactive oxygen scavenging activity, immunomodulation, angiogenesis, osteogenesis. More importantly, SDF-1α/PAFS recruit postoperatively injected into repair. constructed mouse cranial model, experimental confirmed combining injection effectively promote Overall, provides promising better convenience operability.

Language: Английский

Citations

0

Polydopamine-functionalized acellular fish scale scaffolds for accelerated bone tissue regeneration DOI Creative Commons
Shilong Su, Ruideng Wang, Jinwu Bai

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(18), P. 13857 - 13873

Published: Jan. 1, 2025

The complex microenvironment changes in the bone defect site are main reason for its refractory treatment, including significant increase level of reactive oxygen species (ROS) and inflammatory dysregulation. There is an urgent need to develop some bioactive materials that can regulate promote regeneration. This study proposed a new strategy designing tissue engineering scaffolds based on fish scales developed polydopamine-functionalized acellular scale scaffold (PDA-AFS). results showed PDA-AFS had excellent mechanical properties, special three-dimensional surface topography, biodegradability. In vitro good biocompatibility cell adhesion ability, could effectively reduce ROS levels, immunomodulatory activity. More importantly, enhance osteogenic differentiation marrow mesenchymal stem cells endogenous regeneration critical-sized calvarial defects. addition, transcriptome analysis also provided clues possible mechanism. Overall, we provide treatment

Language: Английский

Citations

0