Towards Point-of-Care Single Biomolecule Detection Using Next Generation Portable Nanoplasmonic Biosensors: A Review DOI Creative Commons
Saeed Takaloo, Alexander H. Xu, Liena Zaidan

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 593 - 593

Published: Dec. 4, 2024

Over the past few years, nanoplasmonic biosensors have gained widespread interest for early diagnosis of diseases thanks to their simple design, low detection limit down biomolecule level, high sensitivity even small molecules, cost-effectiveness, and potential miniaturization, name but a benefits. These intrinsic natures technology make it perfect solution compact portable designs that combine sampling, analysis, measurement into miniaturized chip. This review summarizes applications, theoretical modeling, research on biosensor designs. In order develop designs, three basic components been miniaturized: light sources, plasmonic chips, photodetectors. There are five types designs: SPR, components, flexible, wearable SERS-based, microfluidic. The latter design also reduces diffusion times allows amounts samples be delivered near chips. properties nanomaterials nanostructures discussed, which improved performance metrics. Researchers made progress in improving reproducibility these biosensors, is major obstacle commercialization. Furthermore, future trends will focus enhancing metrics, optimizing biorecognition, addressing practical constraints, considering surface chemistry, employing emerging technologies. foreseeable future, merged result offering single biomolecule.

Language: Английский

Photonic Nanomaterials for Wearable Health Solutions DOI Creative Commons
Taewoong Park, Jung Woo Leem, Young L. Kim

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

Citations

3
Trends and Advances in Wearable Plasmonic Sensors Utilizing Surface-Enhanced Raman Spectroscopy (SERS): A Comprehensive Review DOI Creative Commons
Svetlana N. Khonina, Nikolay L. Kazanskiy

Sensors, Journal Year: 2025, Volume and Issue: 25(5), P. 1367 - 1367

Published: Feb. 23, 2025

Wearable sensors have appeared as a promising solution for real-time, non-invasive monitoring in diverse fields, including healthcare, environmental sensing, and wearable electronics. Surface-enhanced Raman spectroscopy (SERS)-based leverage the unique properties of SERS, such plasmonic signal enhancement, high molecular specificity, potential single-molecule detection, to detect identify wide range analytes with ultra-high sensitivity selectivity. However, it is important note that utilize various sensing mechanisms, not all rely on SERS technology, their design depends specific application. This comprehensive review highlights recent trends advancements technologies, focusing design, fabrication, integration into practical devices. Key innovations material selection, use nanomaterials flexible substrates, significantly enhanced sensor performance wearability. Moreover, we discuss challenges miniaturization, power consumption, long-term stability, along solutions address these issues. Finally, outlook technologies presented, emphasizing need interdisciplinary research drive next generation smart wearables capable real-time health diagnostics, monitoring, beyond.

Language: Английский

Citations

3
Wearable SERS devices in health management: Challenges and prospects DOI

Biqing Chen,

Jiayin Gao,

Haizhu Sun

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125957 - 125957

Published: Feb. 26, 2025

Language: Английский

Citations

0
Surface Enhanced Raman Scattering for Biomolecular Sensing in Human Healthcare Monitoring DOI Creative Commons
Stacey Laing, Sian Sloan‐Dennison, Karen Faulds

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Since the 1980s, surface enhanced Raman scattering (SERS) has been used for rapid and sensitive detection of biomolecules. Whether a label-free or labeled assay is adopted, SERS demonstrated low limits in variety biological matrices. However, analysis confined to laboratory due several reasons such as reproducibility scalability, both which have discussed at length literature. Another possible issue with lack widespread adoption that its application point use (POU) testing only now being fully explored advent portable spectrometers. Researchers are investigating how can be output on POU platforms lateral flow assays, wearable sensors, volatile organic compound (VOC) human healthcare monitoring, favorable results rival gold standard approaches. obstacle faces interpretation wealth information obtained from platform. To combat this, machine learning shown provide quick accurate generated data, leading discrimination many clinically relevant This review will discuss advancements combined strength bring produce powerful platform monitoring.

Language: Английский

Citations

0
Highly sensitive and rapid Raman detection of lactic acid in human sweat based on reflective tapered optical fiber DOI
Rui Wang, Xinghua Yang, Fengjun Tian

et al.

Optics & Laser Technology, Journal Year: 2025, Volume and Issue: 188, P. 112975 - 112975

Published: April 14, 2025

Language: Английский

Citations

0
Towards Point-of-Care Single Biomolecule Detection Using Next Generation Portable Nanoplasmonic Biosensors: A Review DOI Creative Commons
Saeed Takaloo, Alexander H. Xu, Liena Zaidan

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 593 - 593

Published: Dec. 4, 2024

Over the past few years, nanoplasmonic biosensors have gained widespread interest for early diagnosis of diseases thanks to their simple design, low detection limit down biomolecule level, high sensitivity even small molecules, cost-effectiveness, and potential miniaturization, name but a benefits. These intrinsic natures technology make it perfect solution compact portable designs that combine sampling, analysis, measurement into miniaturized chip. This review summarizes applications, theoretical modeling, research on biosensor designs. In order develop designs, three basic components been miniaturized: light sources, plasmonic chips, photodetectors. There are five types designs: SPR, components, flexible, wearable SERS-based, microfluidic. The latter design also reduces diffusion times allows amounts samples be delivered near chips. properties nanomaterials nanostructures discussed, which improved performance metrics. Researchers made progress in improving reproducibility these biosensors, is major obstacle commercialization. Furthermore, future trends will focus enhancing metrics, optimizing biorecognition, addressing practical constraints, considering surface chemistry, employing emerging technologies. foreseeable future, merged result offering single biomolecule.

Language: Английский

Citations

2