Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 631 - 631

Published: Jan. 13, 2025

Cancer stem cells (CSC) are known to be the main source of tumor relapse, metastasis, or multidrug resistance and mechanisms counteract eradicate them their activity remain elusive. There different hypotheses that claim origin CSC might in regular (SC) and, due accumulation mutations, these normal become malignant, any malignant cell that, under certain environmental circumstances, acquires all qualities CSC. Multiple studies indicate lifestyle diet represent a wellbeing can prevent ameliorate phenotype In this review, after brief introduction SC CSC, we analyze effects phenolic non-phenolic dietary compounds highlight molecular shown link diets activation colon, breast, prostate cancer. We focus analysis on specific markers such as sphere formation, CD surface markers, epithelial–mesenchymal transition (EMT), Oct4, Nanog, Sox2, aldehyde dehydrogenase 1 (ALDH1) major signaling pathways PI3K/Akt/mTOR, NF-κB, Notch, Hedgehog, Wnt/β-catenin conclusion, better understanding how bioactive our influence dynamics raise valuable awareness towards reducing cancer risk.

Language: Английский

Hypoxia and intrinsic radiosensitivity: Exploring mechanisms in radiation resistance of cancers and biomarkers for enhanced treatment strategies

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101450 - 101450

Published: April 3, 2025

Language: Английский