Mild Oxidation of Plant Polyphenols Yields Modular Nanoparticle‐Forming Materials with Drug Loading Capabilities DOI Open Access
Suhair Sunoqrot,

Samah Abusulieh,

Ilya Anufriev

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Plant polyphenols have attracted interest as green precursors for functional materials due to their unique chemical features. Here, an approach formulate nanoparticles (NPs) from a hydrophobic (quercetin; QCT) and hydrophilic (tannic acid; TA) polyphenol, by leveraging propensity oxidation, is presented. QCT TA are partially oxidized form oxQCT oxTA, respectively. The subsequently used NPs nanoprecipitation alone or in the presence of amphiphilic polymers. Characterization reveals notable change increased thermal stability, with reduced antioxidant anti-inflammatory activities compared unmodified QCT. Conversely, oxTA shows insignificant chemistry pristine TA, yet it displays greater activity, altered activity. Particle size morphology formulated examined dynamic light scattering (DLS), analytical ultracentrifugation (AUC), transmission electron microscopy (TEM). results indicate that co-formulating different polymers impacts particle size, polydispersity index, morphology. Lastly, co-formulated other capable loading drugs such amphotericin B curcumin, forming sub-200 nm high efficiencies, which validates use drug delivery systems.

Language: Английский

Mild Oxidation of Plant Polyphenols Yields Modular Nanoparticle‐Forming Materials with Drug Loading Capabilities DOI Open Access
Suhair Sunoqrot,

Samah Abusulieh,

Ilya Anufriev

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Plant polyphenols have attracted interest as green precursors for functional materials due to their unique chemical features. Here, an approach formulate nanoparticles (NPs) from a hydrophobic (quercetin; QCT) and hydrophilic (tannic acid; TA) polyphenol, by leveraging propensity oxidation, is presented. QCT TA are partially oxidized form oxQCT oxTA, respectively. The subsequently used NPs nanoprecipitation alone or in the presence of amphiphilic polymers. Characterization reveals notable change increased thermal stability, with reduced antioxidant anti-inflammatory activities compared unmodified QCT. Conversely, oxTA shows insignificant chemistry pristine TA, yet it displays greater activity, altered activity. Particle size morphology formulated examined dynamic light scattering (DLS), analytical ultracentrifugation (AUC), transmission electron microscopy (TEM). results indicate that co-formulating different polymers impacts particle size, polydispersity index, morphology. Lastly, co-formulated other capable loading drugs such amphotericin B curcumin, forming sub-200 nm high efficiencies, which validates use drug delivery systems.

Language: Английский

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