Nonlinear Magnetic Response Measurements in Study of Magnetic Nanoparticles Uptake by Mesenchymal Stem Cells DOI Creative Commons
V. A. Ryzhov, Yaroslav Marchenko, V. V. Deriglazov

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(9), P. 675 - 675

Published: April 29, 2025

Stem cells therapies offer a promising approach in translational oncology, as well regenerative medicine due to the tropism of these damage site. To track distribution stem cells, latter could be labeled by MRI-sensitive superparamagnetic (SPM) iron oxide nanoparticles. In current study, magnetic properties nanoparticles (MNPs) incorporated into bone marrow-derived fetal mesenchymal (FetMSCs) were evaluated employing nonlinear response measurements. Synthesized dextran-coated additionally characterized X-ray diffraction, transmission electron microscopy, and dynamic light scattering. The MNP uptake FetMSCs 24 h following coincubation was studied longitudinal weak alternating field with registration second harmonic magnetization. Subsequent data processing using formalism based on numerical solution Fokker–Planck kinetic equation allowed us determine parameters state MNPs culture medium. It found that formed aggregates medium; they absorbed during coincubation. exhibited SPM regime medium, remained virtually unchanged indicating preservation aggregation inside cells. This implies also organic shell FetMSCs. accumulation gradually increased concentration MNPs. Thus, study confirmed labeling MSCs is an effective method for subsequent cell tracking retain their properties.

Language: Английский

Nonlinear Magnetic Response Measurements in Study of Magnetic Nanoparticles Uptake by Mesenchymal Stem Cells DOI Creative Commons
V. A. Ryzhov, Yaroslav Marchenko, V. V. Deriglazov

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(9), P. 675 - 675

Published: April 29, 2025

Stem cells therapies offer a promising approach in translational oncology, as well regenerative medicine due to the tropism of these damage site. To track distribution stem cells, latter could be labeled by MRI-sensitive superparamagnetic (SPM) iron oxide nanoparticles. In current study, magnetic properties nanoparticles (MNPs) incorporated into bone marrow-derived fetal mesenchymal (FetMSCs) were evaluated employing nonlinear response measurements. Synthesized dextran-coated additionally characterized X-ray diffraction, transmission electron microscopy, and dynamic light scattering. The MNP uptake FetMSCs 24 h following coincubation was studied longitudinal weak alternating field with registration second harmonic magnetization. Subsequent data processing using formalism based on numerical solution Fokker–Planck kinetic equation allowed us determine parameters state MNPs culture medium. It found that formed aggregates medium; they absorbed during coincubation. exhibited SPM regime medium, remained virtually unchanged indicating preservation aggregation inside cells. This implies also organic shell FetMSCs. accumulation gradually increased concentration MNPs. Thus, study confirmed labeling MSCs is an effective method for subsequent cell tracking retain their properties.

Language: Английский

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