Physiologically Based RadioPharmacoKinetic (PBRPK) Modeling to Simulate and Analyze Radiopharmaceutical Therapies: Studies of Non-Linearities, Multi-Bolus Injections, and Albumin Binding DOI Creative Commons

Ali Fele‐Paranj,

Babak Saboury,

Carlos Uribe

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 6, 2023

Abstract Background: We aimed to develop a publicly shared computational physiologically based pharmacokinetic (PBPK) model reliably simulate and analyze radiopharmaceutical therapies (RPTs), including probing of hot-cold ligand competitions as well alternative injection scenarios drug designs, towards optimal therapies. Results: To handle the complexity PBPK models (over 150 differential equations), scalable modeling notation called ”reaction graph” is introduced, enabling easy inclusion various interactions. refer this radiopharmacokinetic (PBRPK) modeling, fine-tuned specifically for radiopharmaceuticals. As three important applications, we used our PBRPK (i) study effect competition between hot cold species on delivered doses tumors organs at risk. In addition, (ii) evaluated an paradigm utilizing multi-bolus injections in RPTs instead prevalent single injections. Finally, (iii) impact varying albumin-binding affinities by ligands, implications RPTs. found that labeled unlabeled ligands can lead non-linear relations injected activity dose particular organ, sense doubling does not necessarily result doubled organ (a false intuition from external beam radiotherapy). observed fractionating higher payload delivery organs, though tumor. By contrast, out increased such delivering more tumors, be attributed number factors allows us probe. Conclusions: Advanced enables simulation analysis variety intervention design scenarios,

Language: Английский

[113mIn]In-AMBA: A Novel Diagnostic Agent for SPECT Imaging of GRPR-Expressing Tumors DOI

Mohammad Moazami-Ashtiani,

Saeed Rajabifar,

Samaneh Zolghadri

et al.

Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

0
The radiopharmaceutical renaissance: radiating hope in cancer therapy DOI Creative Commons
Brianne Sullivan, Andrew A. Davis,

Peter Bak

et al.

Biopharma Dealmakers, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The commercial success of second-generation radiopharmaceuticals in oncology has re-ignited interest this modality, resulting a surge dealmaking and increased venture financing for companies the field.

Language: Английский

Citations

1
Preparation and labeling of technitium-99m kit In pharmaceutical grade clean room DOI Open Access
Md. Ruhul Amin,

Azizul Haque,

Avishek Biswas

et al.

Journal of Chemical Engineering, Journal Year: 2014, Volume and Issue: 27(2), P. 31 - 35

Published: Jan. 29, 2014

Technetium-99m radiopharmaceuticals are in widespread use owing to the availability and affordability of 99Mo/99m-Tc generators variety kits for formulating desired products. Together, they provide an array specific tools diagnosing a large number diseases affecting bones major organs body such as heart, brain, liver, kidney thyroid. Nuclear medicine requires high quality that safe administration efficacious given application. In Bangladesh, no commercial production was done before this. This paper presents theoretical basis describes procedures preparing three selected kits. Details ingredients also included. The described here can be used develop manuals standard operating Bangladesh. report is expected serve guide radiopharmaceutical manufacturing centers centralized pharmacies involved current environment It will useful resource many hospital radio pharmacy departments routinely compound 99m-Tc radiopharmaceuticals. Three namely: MDP, DMSA DTPA were prepared. Paper Chromatography disparate polar non-polar part kit-solution finally gamma spectrometry (HPGe) deduce Radiochemical Purity (RCP). By reviewing purity values, it found only has passed 95% barrier which required percentage suggests findings require more practice involve exquisite points, contribute Tc-99m vivo-kits at Radioisotope Production Division (RIPD), AERE, INST their projected future mass successfully. DOI: http://dx.doi.org/10.3329/jce.v27i2.17798 Journal Chemical Engineering, IEB Vol. ChE. 27, No. 2, December 2012: 31-35

Language: Английский

Citations

2
Physiologically Based RadioPharmacoKinetic (PBRPK) Modeling to Simulate and Analyze Radiopharmaceutical Therapies: Studies of Non-Linearities, Multi-Bolus Injections, and Albumin Binding DOI Creative Commons

Ali Fele‐Paranj,

Babak Saboury,

Carlos Uribe

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 6, 2023

Abstract Background: We aimed to develop a publicly shared computational physiologically based pharmacokinetic (PBPK) model reliably simulate and analyze radiopharmaceutical therapies (RPTs), including probing of hot-cold ligand competitions as well alternative injection scenarios drug designs, towards optimal therapies. Results: To handle the complexity PBPK models (over 150 differential equations), scalable modeling notation called ”reaction graph” is introduced, enabling easy inclusion various interactions. refer this radiopharmacokinetic (PBRPK) modeling, fine-tuned specifically for radiopharmaceuticals. As three important applications, we used our PBRPK (i) study effect competition between hot cold species on delivered doses tumors organs at risk. In addition, (ii) evaluated an paradigm utilizing multi-bolus injections in RPTs instead prevalent single injections. Finally, (iii) impact varying albumin-binding affinities by ligands, implications RPTs. found that labeled unlabeled ligands can lead non-linear relations injected activity dose particular organ, sense doubling does not necessarily result doubled organ (a false intuition from external beam radiotherapy). observed fractionating higher payload delivery organs, though tumor. By contrast, out increased such delivering more tumors, be attributed number factors allows us probe. Conclusions: Advanced enables simulation analysis variety intervention design scenarios,

Language: Английский

Citations

1