Exploring the promise of regulator of G Protein Signaling 20: insights into potential mechanisms and prospects across solid cancers and hematological malignancies DOI Creative Commons
Yulu Wang, Jiading Qin, Amit Sharma

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 3, 2024

RGS (Regulator of G protein signaling) proteins have long captured the fascination researchers due to their intricate involvement across a wide array signaling pathways within cellular systems. Their diverse and nuanced functions positioned them as continual subjects scientific inquiry, especially given implications certain family members in various cancer types. Of particular note this context is RGS20, whose clinical relevance molecular significance hepatocellular carcinoma we recently investigated. These investigations prompted questions into prevalence pathogenic mutations RGS20 gene network interacting that could contribute complex landscape biology. In our study, aim unravel multifaceted interplay between other cancer. Expanding on line research dedicated uncovering mechanisms cancers. particular, redirected attention examining role hematological malignancies, with specific focus multiple myeloma follicular lymphoma. cancers hold significant promise for further investigation, understanding pathogenesis unveil novel therapeutic strategies treatment avenues. Furthermore, exploration has extended encompass latest discoveries concerning potential diseases affecting central nervous system, thereby broadening scope its beyond oncology neurobiology related fields.

Language: Английский

Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies DOI Creative Commons
Hui Ma,

Qing-Zhu Yan,

Jingru Ma

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(10), P. 1295 - 1312

Published: March 14, 2024

Hepatitis B virus (HBV) reactivation is a clinically significant challenge in disease management. This review explores the immunological mechanisms underlying HBV reactivation, emphasizing progression and It delves into host immune responses reactivation’s delicate balance, spanning innate adaptive immunity. Viral factors’ disruption of this as are interactions between viral antigens, cells, cytokine networks, checkpoint pathways, examined. Notably, roles T natural killer antigen-presenting cells discussed, highlighting their influence on progression. impact severity, hepatic flares, liver fibrosis progression, hepatocellular carcinoma detailed. Management strategies, including anti-viral immunomodulatory approaches, critically analyzed. The role prophylactic therapy during immunosuppressive treatments explored alongside novel immunotherapeutic interventions to restore control prevent reactivation. In conclusion, comprehensive furnishes holistic view that propel With dedicated focus understanding its implications for prospects efficient management article contributes significantly knowledge base. more profound insights intricate elements system will inform evidence-based ultimately enhancing elevating patient outcomes. dynamic landscape strategies scrutinized, approaches. preventing potential innovative proactively deter

Language: Английский

Citations

8
MicroRNAs in Hepatocellular Carcinoma Pathogenesis: Insights into Mechanisms and Therapeutic Opportunities DOI Open Access
Khadijeh Mahboobnia, Dianne J. Beveridge, George C. Yeoh

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9393 - 9393

Published: Aug. 29, 2024

Hepatocellular carcinoma (HCC) presents a significant global health burden, with alarming statistics revealing its rising incidence and high mortality rates. Despite advances in medical care, HCC treatment remains challenging due to late-stage diagnosis, limited effective therapeutic options, tumor heterogeneity, drug resistance. MicroRNAs (miRNAs) have attracted substantial attention as key regulators of pathogenesis. These small non-coding RNA molecules play pivotal roles modulating gene expression, implicated various cellular processes relevant cancer development. Understanding the intricate network miRNA-mediated molecular pathways is essential for unraveling complex mechanisms underlying hepatocarcinogenesis developing novel approaches. This manuscript aims provide comprehensive review recent experimental clinical discoveries regarding role miRNAs influencing hallmarks HCC, well their promising utility potential targets.

Language: Английский

Citations

6
Prognostic Significance of Ppfibp1 Expression in Early-Stage Lung Adenocarcinoma: A Clinical and Bioinformatics Study DOI

Wenyou Yang,

Bin Zhang,

Xiaxia Mi

et al.

Published: Jan. 1, 2025

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Syzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204 - 5p-Mediated Bcl- 2 Upregulation and Bax/Caspase 9/Caspase 3 Downregulation DOI Creative Commons

Walaa I. E. Abdel-Badeea,

Ahmed Abdel‐Wahab, Ahmed A. Mahmoud

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract The correlation between exposure to environmental pollutants and adverse impacts on fertility has been documented. Cadmium (Cd) is one of the most toxic elements that impairs female reproductive capacity. Syzygium cumini a plant contains polyphenols with strong antioxidant properties. Our study aimed investigate possible protective effects fruit extract (SCFE) quercetin (QU) against Cd-induced ovarian toxicity apoptosis in rats assisted by measuring oxidative stress markers, hormonal profile, intrinsic apoptotic pathway, miRNA-204-5p, histopathology. For that, 45 adult were divided randomly into five groups; control, cadmium chloride (CdCl 2 ), CdCl + QU, SCFE200, SCFE400, experiment lasted 35 days. induced irregular estrus cycle, challenges, as evidenced increased malondialdehyde decreased indicators include superoxide dismutase, catalase reduced glutathione, imbalances, including follicle-stimulating hormone, luteinizing anti-mullarian estrogen, progesterone levels. Additionally, Cd triggered through upregulating miRNA- 204 - 5p expression turn downregulated Bcl- upregulated members mitochondrial pathway Bax caspases 3 , 9 . histopathological findings, morphometric lesion scoring ovarian, uterine tissues confirmed negative Cd. Interestingly, treatment QU or SCFE, especially at higher dose (400 mg/kg), significantly ameliorated these effects, suggesting their potential agents toxicity.

Language: Английский

Citations

0
SP1 undergoes phase separation and activates RGS20 expression through super-enhancers to promote lung adenocarcinoma progression DOI Creative Commons

Liying Shan,

Wenmeng Wang, Lijuan Du

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(29)

Published: July 8, 2024

Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, but underlying molecular mechanisms remain largely unclear. The transcription factor (TF) specificity protein 1 (SP1) plays a crucial role in development various cancers, including LUAD. Recent studies have indicated that master TFs may form phase-separated macromolecular condensates to promote super-enhancer (SE) assembly and oncogene expression. In this study, we demonstrated SP1 undergoes phase separation its zinc finger 3 DNA-binding domain essential for process. Through Cleavage Under Targets & Release Using Nuclease (CUT&RUN) using antibodies against H3K27ac, found significant correlation between enrichment SE elements, identified regulator G signaling 20 (RGS20) gene as most likely target regulated by through mechanisms, verified finding different approaches. oncogenic activity relies on ability RGS20 activation, which can be abolished glycogen synthase kinase J4 (GSK-J4), demethylase inhibitor. Together, our findings provide evidence regulates expression thereby promoting LUAD cell progression. This study also revealed an innovative therapies intervening SP1-mediated formation.

Language: Английский

Citations

3
Exploring the promise of regulator of G Protein Signaling 20: insights into potential mechanisms and prospects across solid cancers and hematological malignancies DOI Creative Commons
Yulu Wang, Jiading Qin, Amit Sharma

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 3, 2024

RGS (Regulator of G protein signaling) proteins have long captured the fascination researchers due to their intricate involvement across a wide array signaling pathways within cellular systems. Their diverse and nuanced functions positioned them as continual subjects scientific inquiry, especially given implications certain family members in various cancer types. Of particular note this context is RGS20, whose clinical relevance molecular significance hepatocellular carcinoma we recently investigated. These investigations prompted questions into prevalence pathogenic mutations RGS20 gene network interacting that could contribute complex landscape biology. In our study, aim unravel multifaceted interplay between other cancer. Expanding on line research dedicated uncovering mechanisms cancers. particular, redirected attention examining role hematological malignancies, with specific focus multiple myeloma follicular lymphoma. cancers hold significant promise for further investigation, understanding pathogenesis unveil novel therapeutic strategies treatment avenues. Furthermore, exploration has extended encompass latest discoveries concerning potential diseases affecting central nervous system, thereby broadening scope its beyond oncology neurobiology related fields.

Language: Английский

Citations

1