The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies DOI Creative Commons

Mo‐Yao Tan,

Yujun Zhang,

Si-Xuan Zhu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 24, 2025

The American Heart Association (AHA) proposed the concept of cardiovascular–kidney–metabolic (CKM) syndrome, underscoring interconnectedness cardiovascular, renal, and metabolic diseases. stress hyperglycemia ratio (SHR) represents an innovative indicator that quantifies blood glucose fluctuations in patients experiencing acute or subacute stress, correlating with detrimental clinical effects. Nevertheless, prognostic significance SHR within individuals diagnosed CKM syndrome stages 0 to 3, particularly respect all-cause cardiovascular disease (CVD) mortality risks, has not been fully understood yet. current study analyzed data from 9647 participants covering based on NHANES (National Health Nutrition Examination Survey) collected 2007 2018. In this study, primary exposure variable was SHR, computed as fasting plasma divided by (1.59 * HbA1c − 2.59). main endpoints were well CVD mortality, death registration sourced through December 31, 2019. CHARLS database (China Retirement Longitudinal Study) utilized validation enhance reliability findings. This included participants, who followed for a median duration 6.80 years. During period, 630 cases 135 CVD-related deaths total recorded. After full adjustment covariates, our results displayed robust positive association (Hazard [HR] = 1.09, 95% Confidence interval [CI] 1.04–1.13). However, exhibited no significant relationship (HR 1.00, CI 0.91–1.11). mediation analysis suggested between risk is partially mediated RDW, albumin, RAR. Specifically, mediating effects 17.0% (95% 46.7%, 8.7%), 10.1% 23.9%, 4.7%), 23.3% 49.0%, 13.0%), respectively. Additionally, analyses indicated correlation among across 0–3 during follow-up period 2011 2020. An increased value positively associated elevated likelihood 0–3, yet it shows mortality. important tool predicting long-term adverse outcomes population. Cardiovascular–kidney–metabolic emphasizes kidney, novel marker reflecting stress-induced fluctuations, but its (stages 0–3) remains uncertain. explores Our findings indicate significantly 1.04–1.13), CI: Mediation Validation using supports these These suggest could serve biomarker patients, offering potential utility stratification management.

Language: Английский

Baicalin and baicalein against myocardial ischemia-reperfusion injury: a review of the current documents DOI

Reza Nasiri,

Reza Arefnezhad,

Kimia Baniasad

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102772 - 102772

Published: Feb. 5, 2025

Language: Английский

Citations

0
The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies DOI Creative Commons

Mo‐Yao Tan,

Yujun Zhang,

Si-Xuan Zhu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 24, 2025

The American Heart Association (AHA) proposed the concept of cardiovascular–kidney–metabolic (CKM) syndrome, underscoring interconnectedness cardiovascular, renal, and metabolic diseases. stress hyperglycemia ratio (SHR) represents an innovative indicator that quantifies blood glucose fluctuations in patients experiencing acute or subacute stress, correlating with detrimental clinical effects. Nevertheless, prognostic significance SHR within individuals diagnosed CKM syndrome stages 0 to 3, particularly respect all-cause cardiovascular disease (CVD) mortality risks, has not been fully understood yet. current study analyzed data from 9647 participants covering based on NHANES (National Health Nutrition Examination Survey) collected 2007 2018. In this study, primary exposure variable was SHR, computed as fasting plasma divided by (1.59 * HbA1c − 2.59). main endpoints were well CVD mortality, death registration sourced through December 31, 2019. CHARLS database (China Retirement Longitudinal Study) utilized validation enhance reliability findings. This included participants, who followed for a median duration 6.80 years. During period, 630 cases 135 CVD-related deaths total recorded. After full adjustment covariates, our results displayed robust positive association (Hazard [HR] = 1.09, 95% Confidence interval [CI] 1.04–1.13). However, exhibited no significant relationship (HR 1.00, CI 0.91–1.11). mediation analysis suggested between risk is partially mediated RDW, albumin, RAR. Specifically, mediating effects 17.0% (95% 46.7%, 8.7%), 10.1% 23.9%, 4.7%), 23.3% 49.0%, 13.0%), respectively. Additionally, analyses indicated correlation among across 0–3 during follow-up period 2011 2020. An increased value positively associated elevated likelihood 0–3, yet it shows mortality. important tool predicting long-term adverse outcomes population. Cardiovascular–kidney–metabolic emphasizes kidney, novel marker reflecting stress-induced fluctuations, but its (stages 0–3) remains uncertain. explores Our findings indicate significantly 1.04–1.13), CI: Mediation Validation using supports these These suggest could serve biomarker patients, offering potential utility stratification management.

Language: Английский

Citations

0