Efficacy equivalence but hidden hurdles: Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 19, 2025

This article discusses the study by Xiao et al, which investigated therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in a mouse model knee osteoarthritis. The results showed that N-hUCMSCs alleviated osteoarthritis-related cartilage damage and inflammation comparably to both serum-cultured hUCMSCs hyaluronic acid. While these findings broaden potential clinical utility circumventing certain drawbacks serum-based cultures, equivalence raises important questions. First, how do differ phenotypically from hUCMSCs, particularly terms proliferation rate, replicative capacity, senescence profile? Second, what advantages might offer over acid - well-established therapy beyond avoiding xenogeneic components ethical concerns? Future research should focus on long-term phenotypic stability, sustained functional benefits, safety profiles, mechanistic insights ascertain whether can surpass current standards care.

Language: Английский

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From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2052 - 2052

Published: Dec. 12, 2024

Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.

Language: Английский

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Mesenchymal Stem Cells: What We Have Learned and How to Manage Them

Biology, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Regenerative medicine is the new frontier of [...].

Language: Английский

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