DNA as a Promising Biomaterial for Bone Regeneration and Potential Mechanisms of Action DOI Creative Commons

Nadeen Meshry,

Karina M. M. Carneiro

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Decoding interactions between biofilms and DNA nanoparticles DOI Creative Commons

Alexandra Sousa,

R.G. Kulkarni,

Mona Johannessen

et al.

Biofilm, Journal Year: 2025, Volume and Issue: 9, P. 100260 - 100260

Published: Feb. 6, 2025

Biofilms present a great challenge in antimicrobial therapy due to their inherent tolerance conventional antibiotics, promoting the need for advanced drug delivery strategies that improve therapy. While various nanoparticles (NPs) have been reported this purpose, DNA-based NPs remain largely unexploited resource against biofilm-associated infections. To fill gap and lay groundwork potential therapeutic exploitation, we investigated diffusion, penetration, retention behaviors of three nanocarriers -plain or modified-within P. aeruginosa biofilms. Watson-Crick base pairing hydrophobic interactions mediated formation plain whilst electrostatic interaction enabled optimization coated via microfluidic mixing. We assessed with biofilm structures Single Plane Illumination Microscopy - Fluorescence Correlation Spectroscopy (SPIM-FCS) Confocal Laser Scanning (CLSM). demonstrate impact parameters on physicochemical properties modified DNA subsequent distinct biofilm. Our results show single stranded micelles (ssDNA micelle) tetrahedral nanostructures (TDN) had similar diffusion penetration profiles, whereas chitosan-coated TDN (TDN-Chit) showed reduced increased retention. This is attributable relatively larger size positive surface charge TDN-Chit NPs. The study shows first foremost can be used as building block antibiofilm therapeutics. Moreover, overall behavioral findings are pivotal strategic selection agents encapsulated within these structures, possibly affecting treatment efficacy. research not only highlights underexplored but also advocates further studies using different refine nanocarrier systems targeted treatments biofilm-related

Language: Английский

Citations

0
Magnetically Controlled All-in-One Sensing Platform for Triple-Mode Detection of Organophosphorus Pesticides Using DNA Tetrahedrons-Polydopamine Reporters DOI

Haiwen Xiao,

Jianing Ma,

Zihan Liu

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 276, P. 117258 - 117258

Published: Feb. 12, 2025

Language: Английский

Citations

0
Self-Assembled DNA Nanocarriers for Treating Bone Fracture and Surgery-related MRSA Infection DOI Creative Commons
Jiaqi Huang, Aishik Chakraborty, Yasmeen Shamiya

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating osteoporosis and related Methicillin-resistant Staphylococcus aureus (MRSA) infection in bone surgery. successfully synthesized TDNs demonstrated their excellent cytocompatibility on blood cells immune cells. Zoledronic acid-loaded TDN displayed increased efficacy regulating remodeling while vancomycin-loaded showed an antibacterial effect against MRSA. This nanomedicine may potentially enhance the therapeutic of zoledronic acid overcoming antibiotic resistance.

Language: Английский

Citations

0
DNA as a Promising Biomaterial for Bone Regeneration and Potential Mechanisms of Action DOI Creative Commons

Nadeen Meshry,

Karina M. M. Carneiro

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0