ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(6), P. 5841 - 5852
Published: March 1, 2024
In
the
realm
of
surface-enhanced
Raman
scattering
(SERS)
research,
precise
detection
and
effective
cleansing
substances
are
critical.
This
study
introduces
a
novel
Au
nanotriangle/Cs2AgBiBr6
(Au
NT/CABB)
SERS
array,
synthesized
through
meticulous
two-step
process,
which
demonstrates
remarkable
effectiveness.
Using
Rhodamine
6G
(R6G)
as
probe
molecule,
this
substrate
accurately
detects
target
molecules
achieves
an
exceptional
threshold
1
×
10–13
M.
The
integration
CABB
into
endows
it
with
photocatalytic
properties,
thereby
accelerating
degradation
adsorbed
signaling
significantly
enhancing
reusability
NT/CABB
arrays.
Furthermore,
arrays
exhibit
outstanding
performance
methylene
blue
(MB)
MB&R6G
mixed
solutions,
distinguishing
between
two
signal
high
fidelity.
Additionally,
enhancement
mechanism
array
is
analyzed
by
finite-difference
time-domain
(FDTD)
simulation
energy
band
structure.
These
findings
highlight
substrate's
dual
capability
in
leveraging
both
electromagnetic
chemical
mechanisms
for
superior
performance,
complemented
integrated
self-cleaning
feature,
making
promising
candidate
environmental
applications.
ACS Synthetic Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 21 - 40
Published: Jan. 6, 2025
The
field
of
healthcare
diagnostics
is
navigating
complex
challenges
driven
by
evolving
patient
demographics
and
the
rapid
advancement
new
technologies
worldwide.
In
response
to
these
challenges,
biosensors
offer
distinctive
advantages
over
traditional
diagnostic
methods,
such
as
cost-effectiveness,
enhanced
specificity,
adaptability,
making
their
integration
with
point-of-care
(POC)
platforms
more
feasible.
recent
years,
aptasensors
have
significantly
evolved
in
capabilities
through
emerging
microfluidics,
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)
systems,
wearable
devices,
machine
learning
(ML),
driving
progress
precision
medicine
global
solutions.
Moreover,
advancements
not
only
improve
accuracy
but
also
hold
potential
revolutionize
early
detection,
reduce
costs,
outcomes,
especially
resource-limited
settings.
This
Account
examines
key
advancements,
focusing
on
how
scientific
breakthroughs,
including
artificial
intelligence
(AI),
improved
sensitivity
precision.
Additionally,
has
enabled
real-time
monitoring
data
analysis,
fostering
advances
personalized
healthcare.
Furthermore,
commercialization
aptasensor
could
increase
availability
clinical
settings
support
use
widespread
solutions
for
health
challenges.
Hence,
this
review
discusses
technological
improvements,
practical
uses,
prospects
while
surrounding
standardization,
validation,
interdisciplinary
collaboration
application.
Finally,
ongoing
efforts
address
are
ensure
that
can
be
effectively
implemented
diverse
systems.
Sensors,
Journal Year:
2025,
Volume and Issue:
25(3), P. 848 - 848
Published: Jan. 30, 2025
Exosomes
carry
diverse
tumor-associated
molecular
information
that
can
reflect
real-time
tumor
progression,
making
them
a
promising
tool
for
liquid
biopsy.
However,
traditional
methods
exosome
isolation
and
detection
often
rely
on
large,
expensive
equipment
are
time-consuming,
limiting
their
practical
applicability
in
clinical
settings.
Microfluidic
technology
offers
versatile
platform
analysis,
with
advantages
such
as
seamless
integration,
portability
reduced
sample
volumes.
Aptamers,
which
single-stranded
oligonucleotides
high
affinity
specificity
target
molecules,
have
been
frequently
employed
the
development
of
aptamer-based
microfluidics
isolation,
signal
amplification,
quantitative
exosomes.
This
review
summarizes
recent
advances
microfluidic
strategies
including
(1)
on-chip
capture
mediated
by
aptamers
combined
nanomaterials
or
nanointerfaces;
(2)
amplification
techniques,
enzyme-free
hybridization
chain
reaction
(HCR),
rolling
circle
(RCA),
DNA
machine-assisted
amplification;
(3)
various
aptamer-assisted
methods,
fluorescence,
electrochemistry,
surface-enhanced
Raman
scattering
(SERS),
magnetism.
The
limitations
these
also
summarized.
Finally,
future
challenges
directions
analysis
exosomes
based
discussed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3728 - 3728
Published: April 26, 2023
Many
biological
processes
(physiological
or
pathological)
are
relevant
to
membrane
proteins
(MPs),
which
account
for
almost
30%
of
the
total
human
proteins.
As
such,
MPs
can
serve
as
predictive
molecular
biomarkers
disease
diagnosis
and
prognosis.
Indeed,
cell
surface
an
important
class
attractive
targets
currently
prescribed
therapeutic
drugs
diagnostic
molecules
used
in
detection.
The
oligonucleotides
known
aptamers
be
selected
against
a
particular
target
with
high
affinity
selectivity
by
iterative
rounds
vitro
library
evolution,
Systematic
Evolution
Ligands
EXponential
Enrichment
(SELEX).
alternative
antibodies,
offer
unique
features
like
thermal
stability,
low-cost,
reuse,
ease
chemical
modification,
compatibility
various
detection
techniques.
Particularly,
immobilized-aptamer
sensing
platforms
have
been
under
investigation
diagnostics
demonstrated
significant
value
compared
other
analytical
These
“aptasensors”
classified
into
several
types
based
on
their
working
principle,
commonly
electrochemical,
optical,
mass-sensitive.
In
this
review,
we
review
studies
aptamer-based
MP-sensing
technologies
applications
included
new
methodological
variations
undertaken
recent
years.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(4), P. 481 - 481
Published: April 16, 2023
Breast
cancer
(BC),
one
of
the
most
common
and
life-threatening
cancers,
has
highest
incidence
rate
among
women.
Early
diagnosis
BC
oncomarkers
is
considered
effective
strategy
for
detecting
treating
BC.
Finding
type
stage
in
women
as
soon
possible
greatest
ways
to
stop
its
negative
effects
on
medical
treatment.
The
development
biosensors
early,
sensitive,
selective
detection
recently
attracted
much
attention.
An
electrochemical
nano
biosensor
(EN)
a
very
suitable
option
powerful
tool
diagnosis.
This
comprehensive
review
provides
information
about
prevalence
pathobiology
BC,
recent
advances
clinically
available
oncomarkers,
point-of-care
(POC)
various
using
nanomaterial-based
signal
amplification
techniques.
