Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5691 - 5691
Published: Dec. 2, 2024
Polyhedron gold nanocrystals enclosed by high-index facets (HIF-Au NCs) are in high demand but very difficult to prepare. To address this issue, we presented a simple, seedless method for synthesizing uniform HIF-Au NCs an aqueous solution, which remarkably reduced the synthesis difficulty. Interestingly, protonated N
Language: Английский
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 344 - 344
Published: Feb. 27, 2025
Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.
Language: Английский
Citations
1
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
This paper describes the first use of conductive metal–organic frameworks as active material in electrochemical detection nitric oxide aqueous solution. Four hexahydroxytriphenylene (HHTP)-based MOFs linked with first-row transition metal nodes (M = Co, Ni, Cu, Zn) were compared thin-film working electrodes for promoting oxidation NO using voltammetric and amperometric techniques. Cu- Ni-linked MOF analogs provided signal enhancement 5- to 7-fold over a control glassy carbon electrode (SANO 6.7 ± 1.2 5.7 1.1 Ni3(HHTP)2 Cu3(HHTP)2, respectively) detecting micromolar concentrations NO. Zinc-based offered more limited 3.1 0.5), while cobalt-based analog had intrinsic redox activity at potentials close oxidation, which interfered sensing. Combining polymer improved stability under repeated scanning (14 3% decrease 10 scans). The stabilized Ni3(HHTP)2@polymer-coated able detect physiologically relevant (LOD 9.0 4.8 nM) sensing experiments, exhibited moderate selectivity against ascorbic acid nitrite (log kj,NO −1.3 0.3 −0.83 0.68 nitrite, respectively). study demonstrates that layered, 2D have promising applicability environments.
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
The development of portable electronic chemical sensors is key to solving a number challenges, including monitoring environmental and industrial hazards, as well understanding improving human health. Framework materials possess several desirable characteristics that make them well-suited for electroanalytical applications, high surface area, atomically precise distribution active sites, tunable properties can be leveraged through modular reticular chemistry. This review highlights the emergence conductive framework components in electrically transduced sensors, new detection wide variety analytes both gas liquid phase. efforts gain fundamental molecular interactions sensing mechanisms between are described, along with applications these on flexible substrates. suggests areas further study, study material–analyte at level continued scalable methods integration into low-power, devices.
Language: Английский
Citations
0
Advanced Sensor Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Abstract Advancements in sensor technologies capable of measuring key biomarkers can greatly enhance medical diagnostics and health monitoring, facilitating more effective diagnosis, treatment, prevention. While there are numerous interest, gaseous ammonia (NH 3 ) stands out due to its significance as an indicator organ function (e.g., liver kidney failure) or bacterial infections Helicobacter pylori , Proteus mirabilis the body. This review discusses metabolism presence NH body organs, well clinical conditions associated with regulation concentrations. paper reviews various sensing materials parameters, along current state‐of‐the‐art gas sensors detecting for biomedical applications. Additionally, it addresses challenges faced by already use highlights that while applications breath analysis well‐developed, vivo remains early stages faces significant challenges. Finally, promising future research directions discussed, including integration catheters Simulator Human Intestinal Microbial Ecosystem, detection antibiotic‐resistant bacteria diagnostics.
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108569 - 108569
Published: May 8, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5691 - 5691
Published: Dec. 2, 2024
Polyhedron gold nanocrystals enclosed by high-index facets (HIF-Au NCs) are in high demand but very difficult to prepare. To address this issue, we presented a simple, seedless method for synthesizing uniform HIF-Au NCs an aqueous solution, which remarkably reduced the synthesis difficulty. Interestingly, protonated N
Language: Английский
Citations
0