Published: Sept. 8, 2024
Language: Английский
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117362 - 117362
Published: March 1, 2025
Language: Английский
Citations
1
International Journal of Mechanical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 109949 - 109949
Published: Jan. 1, 2025
Citations
0
Electrical Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
With the goal of impacting patient quality life and outcomes, sensor science offers significant potential to revolutionize healthcare by providing advances in detection molecular biomarkers for personalized clinical technologies. The community has achieved technical advancements that can impact diagnostics, health monitoring, disease treatment; however, many innovations remain confined laboratory, failing bridge translational gap between research real-world applications. This perspective presents a new direction community, where development centers on needs experiences primary beneficiaries: patients. We provide guidelines resources researchers engage with patients early continuously throughout process inform specifications better align technologies needs, improving their adoption impact. also present examples implementing patient-centered approach planning engagement research. In design impactful sensors patients, must expand focus beyond embrace approach, which will likely lead opportunities collaboration evolution community.
Language: Английский
Citations
0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: May 6, 2025
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0
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: May 17, 2025
The isolation and detection of exosomes as tumor markers are vital importance for the early diagnosis, therapeutic monitoring, mechanistic studies tumors. Here, derived from breast cancer cells were chosen model targets, a wash-free, enzyme-free, handheld mini centrifugation method based on hydrogels was developed to effectively isolate detect exosomes. Dual aptamers (CD63-T1 EpCAM-T2) employed specifically recognize capture This specific recognition triggered formation hybridization chain reaction (HCR) nanostructures captured through interaction hairpin 1 alginate complex (H1-Alg) 2 (H2-Cy3). Ca2+ enabled in situ hydrogel exosome surface. Subsequent low-speed using centrifuge facilitated efficient exosomes, thereby eliminating need tedious washing steps. Utilizing classical chelation ethylene diamine tetraacetic acid (EDTA) with Ca2+, can be rapidly cleaved enzyme-free release demonstrated excellent efficiencies approximately 85% 98%, respectively, cancerous Notably, isolated by system retained biological activity, making them suitable further analysis potential applications. Meanwhile, highly sensitive this strategy could also achieved lower limit low 3.2 × 103 particles/mL. work provides novel cost-effective effective tumor-derived which help promote subsequent application research.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164316 - 164316
Published: June 1, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: April 16, 2024
Background Lung cancer, characterized by its high morbidity and lethality, necessitates thorough research to enhance our understanding of pathogenesis discover novel therapeutic approaches. Recent studies increasingly demonstrate that lung cancer cells can modulate the tumor microenvironment, promoting growth, metastasis through release exosomes. Exosomes are small vesicles secreted contain a variety bioactive molecules such as proteins, nucleic acids, metabolites. This paper presents comprehensive review exosome in progress bibliometric analysis. Methods Publications related exosomes patients were systematically searched on Web Science Core Collection (WoSCC) database. Bibliometric analysis was performed using VOSviwers, CiteSpace, R package “Bibliometrics”. quantitatively analyzed Microsoft Office Excel 2019. The language publication restricted “English” search strategy employed TS=(exosomes or exosomes) TS=(lung cancer). period commenced January 1, 2004, concluded November 12, 2023, at noon. selected literature types included Articles Reviews. Results study encompassed 1699 papers from 521 journals across 71 countries 2105 institutions. Analysis revealed consistent upward trend over years, with notable surge recent times. indicates growing interest depth inquiry into Major institutions China United States, including Nanjing Medical University, Shanghai Jiao Tong Chinese Academy Of Sciences, Utmd Anderson Cancer Center, emerged crucial hubs. annual count this field witnessed continuous rise, particularly years. Key terms non-small cell (NSCLC), microvesicles, intercellular communication, exosomal miRNAs, oncology dominated landscape. Fields like biology, biochemistry, biotechnology, exhibited close relation research. Clotilde Théry most cited author field, underlining her significant contributions. These results broad impact key covering not only disease-specific aspects NSCLC but also basic biological concepts microvesicles communication. Explorations microRNAs have opened new avenues for In summary, is poised continue receiving attention, potentially leading breakthroughs treatment prevention. Conclusion show rising year year, States ranking first second number publications. However, there insufficient academic learning cooperation exchanges between two sides, universities account large proportion field. Jing Li productive author, co-cited Cancers journal highest current focus biomarkers, liquid biopsies, immunotherapy, microenvironment.
Language: Английский
Citations
1
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(3)
Published: June 1, 2024
Abstract Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, play crucial roles in cellular communication disease processes. Among these, exosomes are particularly significant for diagnosing, cancer (which remains a leading cause of death worldwide). Exosomes offer cutting‐edge approaches nanomedicine, biomarkers investigation (diagnosis prognosis), therapeutic. found several body fluids (Blood, plasma, serum, urine, saliva, sweat, CSF, tear). It transforms the liquid biopsy method with more specificity. Exosome‐based sensor (electrochemical aptamer‐based) developers were effective sensitive scanning. Therapeutic prospect stem cell‐derived plant‐derived become promising. Due to its non‐toxicity (depending on source), non‐immunogenic, biocompatibility ability cross biological membranes. an exciting nano‐drug transporter Current time‐modified support development effective, efficient, cost‐effective nanomedicine against cancer. Advanced nanotechnology exosome combining (single profiling, barcoding)transform theranostics approaches. introduce new horizon nanomedicine.
Language: Английский
Citations
1
Published: Sept. 8, 2024
Language: Английский
Citations
0