ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Two-dimensional
(2D)
materials
have
captivated
scientific
imagination,
and
among
this
proliferating
cadre
of
2D
compounds,
borophene;
a
single
layer
boron
atoms
emerges
as
nonpareil
substance
owing
to
its
distinctive
structural,
electronic,
mechanical
properties.
This
review
investigates
the
extraordinary
properties
that
borophene
possesses,
notably
in
χ3
β12
phases,
which
add
directional
metallic
behavior,
along
with
quite
lot
plasticity
high
carrier
mobility.
The
synthesis
has
made
significant
strides
thanks
cutting-edge
techniques
like
molecular
beam
epitaxy
(MBE),
atomic
deposition
(ALD),
chemical
vapor
(CVD)
physical
(PVD),
recent
innovations
breaking
through
scalability
no-go
areas
that,
past,
hindered
material's
widespread
use.
Borophene's
superior
thermal,
properties,
contrast
other
graphene,
accentuate
potential
for
diverse
applications,
particularly
realm
next-generation
sensors.
It
places
particular
emphasis
on
borophene's
appositeness
sensor
technology,
detailing
structural
intricacies
unique
topological
characteristics
make
an
exceptional
candidate.
By
focusing
mechanisms
enable
sensitivity
flexibility,
discussion
brings
light
transformative
interesting
material
while
concurrently
addressing
state-of-the-art
advancements
research,
thereby
providing
forward-looking
perspective
future
opportunities
challenges.
Ultimately,
work
pinpoints
how
borophene,
unprecedented
technological
promise,
is
poised
reshape
technology
opens
new
avenues
exploration
broader
field
advanced
functional
materials.
Microchimica Acta,
Journal Year:
2025,
Volume and Issue:
192(4)
Published: March 11, 2025
Abstract
An
electrochemical
DNA
biosensor
is
presented
for
early
viral
infection
detection,
integrating
molybdenum
disulphide
(MoS₂),
tetrahedral
nanostructures
(TDNs),
and
thionine-modified
carbon
nanodots
(CNDsTy).
The
innovation
of
this
work
lies
in
the
first-time
integration
these
nanomaterials
preparation
a
bioconjugate,
whose
synergy
enables
biosensor’s
functionality.
MoS₂
anchors
TDNs,
which
carry
capture
probe
virus
identification
via
genetic
code
recognition.
CNDsTy
allow
detection
based
on
their
different
affinity
single-stranded
(ssDNA)
double-stranded
(dsDNA),
enabling
hybridization
event
identification.
achieves
high
sensitivity
(detection
limit
5.00
fM)
can
distinguish
loads,
validated
with
SARS-CoV-2
ORF1ab
sequence
human
nasopharyngeal
samples.
Graphical
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 14, 2025
Exosomes
have
emerged
as
vital
biomarkers
for
cancer
diagnosis
because
they
carry
diverse
biomolecules,
reflecting
the
physiological
state
of
their
original
cells.
However,
despite
this
potential,
there
are
still
challenges
in
developing
highly
sensitive,
rapid,
and
efficient
detection
methods
clinical
diagnosis.
Here,
we
present
a
straightforward
approach
enrichment
SERS
quantification
exosomes
via
interaction
between
titanium
dioxide
(TiO2)
phospholipid
bilayer
on
exosome
membrane.
First,
Fe3O4@TiO2
was
employed
rapid
enrichment,
enabling
magnetic
separation
from
biological
fluids.
Subsequently,
surface-enhanced
Raman
scattering
(SERS)
tags,
Ag@NTP@TiO2,
were
applied
to
label
precise
quantification.
Ag@NTP@TiO2
exhibited
strong
homogeneous
signals.
The
TiO2
shell
tags
not
only
facilitated
labeling
rapidly
but
also
ensured
long-term
stability
It
avoided
high
cost
time-consuming
disadvantages
traditional
method
recognizing
with
antibodies
aptamers.
Our
enabled
quantitative
capture
measurement
within
10
min.
range
spanned
5
orders
magnitude,
limit
low
640
particles/mL.
In
plasma
sample
testing,
good
ability
distinguishing
patients
healthy
individuals,
an
area
under
curve
(AUC)
0.880.
All
these
results
suggest
that
our
may
become
powerful
tool
liquid
biopsy
based
analysis
clinics.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.