Renal-Clearable Biomass-Derived Carbon Dots with Red Fluorescence for Masked Cryptic Kidney Injury Imaging

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Masked cryptic kidney injury (MCKI), an early stage of acute (AKI), is challenging to detect and diagnose, especially in the modern context where toxic substances, such as surfactants, are increasingly misused. Consequently, there urgent need for methods visual diagnosis MCKI. In this study, we synthesized environmentally friendly spirulina-derived carbon dots (SpiCDs) using spirulina a biobased raw material through simple hydrothermal process. These SpiCDs, with their ultrasmall size, enable efficient renal clearance. cellular experiments, SpiCDs rapidly entered SDS-damaged cells, facilitating dynamic monitoring cell membrane damage vivo animal experiments demonstrated that were efficiently excreted kidneys began accumulate bladder within 10 min after tail vein injection. The detection red fluorescence urine confirmed metabolic pathway SpiCDs. Furthermore, MCKI model induced by SDS, showed accelerated excretion earlier accumulation bladder, indicating increased sensitivity injury. results suggest provide promising approach MCKI, offering insights into its monitoring.

Language: Английский

Ratiometric Photoacoustic Imaging Probe for Self-Predicting Nanozyme Therapeutic Effects

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Nanozymes with intrinsic enzyme-like properties have garnered significant attention in cancer treatment. However, effective methods to evaluate situ the catalytic activity of nanozymes living systems remain lacking. Herein, we pioneeringly present a novel probe (1-FCuSA) for self-reporting nanozyme activity, which integrates diene electrochromic material (EM 1) and copper single-atom (FCuSA) peroxidase (POD)-like activity. This system is designed self-predict its through ratiometric photoacoustic (PA) imaging signal. Initially, 1-FCuSA exhibits low PA ratio (PA808/PA1064) between 808 1064 nm. Upon reaction hydroxyl radicals (•OH) generated by POD-like FCuSA, signal at nm significantly increases, while remains stable. results an obvious increase PA808/PA1064, enabling accurate monitoring •OH production during nanozyme-catalyzed therapy. Thus, not only induces specific vivo tumor treatment but also provides real-time efficiency imaging. innovative approach may offer new insights into early prediction anticancer efficacy guide application systems.

Language: Английский

Self-assembled Ti3C2Tx/MnFe2O4 hybrid Schottky junction sensor: A breakthrough in electron transfer enhancement and low detection limit for hydroxyl radical detection

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113697 - 113697

Published: April 1, 2025

Language: Английский