Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(8), P. 5232 - 5241
Published: Feb. 13, 2024
In
pursuit
of
potent
pharmaceutical
candidates
and
to
further
improve
their
chemical
traits,
small
ring
systems
can
serve
as
a
potential
starting
point.
Small
units
have
the
additional
merit
loaded
strain
at
core,
making
them
suitable
reactants
they
capitalize
on
this
intrinsic
driving
force.
With
introduction
cyclobutenone
strained
precursor
ketene,
photocycloaddition
with
another
unit,
bicyclo[1.1.0]butane
(BCB),
enables
reactivity
both
π-units
in
transient
ketene.
This
double
strain-release
driven
[2π+2σ]-photocycloaddition
promotes
synthesis
diverse
heterobicyclo[2.1.1]hexane
units,
pharmaceutically
relevant
bioisostere.
The
effective
under
catalyst-free
conditions
high
functional
group
tolerance
defines
its
synthetic
utility.
Experimental
mechanistic
studies
density
theory
(DFT)
calculations
suggest
that
takes
place
via
triplet
mechanism.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(4), P. 1732 - 1737
Published: Jan. 1, 2022
A
general
visible-light-induced
catalyst-/additive-free
strategy
was
developed
for
the
construction
of
various
aroylated
heterocyclesunder
air
and
room
temperature
conditions.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(11), P. 3273 - 3280
Published: Jan. 1, 2022
Visible
light
induced
singlet
nucleophilic
carbenes
undergo
rapid
[2
+
1]-cycloaddition
with
tethered
olefins
to
afford
unique
bicyclo[3.1.0]hexane
and
bicyclo[4.1.0]heptane
scaffolds.
This
cyclopropanation
process
requires
only
visible
irradiation
proceed,
circumventing
the
use
of
exogenous
(photo)catalysts,
sensitisers
or
additives
showcases
a
vastly
underexplored
mode
reactivity
for
in
chemical
synthesis.
The
discovery
additional
transformations
including
cyclopropanation/retro-Michael/Michael
cascade
chromanones
photochemical
C-H
insertion
reaction
are
also
described.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(8), P. 3182 - 3193
Published: Feb. 13, 2023
Combining
more
than
two
metal–organic
frameworks
(MOFs)
with
different
structures
is
an
intelligent
strategy
for
the
architecture
of
hybrid
MOFs.
Herein,
well-organized
UiO-66(Zr)-on-MIL-125(Ti)-NH2
growth
g-C3N4
nanosheets
was
developed
Gomberg–Buchmann–Hey
reaction
under
visible
light
irradiation
(λ
>
420
nm).
First,
UiO-66(Zr)
micropores
as
host
MOFs
were
fabricated
by
a
solvothermal
method.
Subsequently,
MIL-125(Ti)-NH2
crystals
and
grown
inside
to
obtain
new
type
dual
Z-scheme
Zr-MOF/Ti-MOF/g-C3N4
heterojunction
photocatalyst.
Under
irradiation,
this
acts
highly
efficient
photocatalyst
forming
C–C
bonds
via
diazonium
salts,
which
can
compete
best
systems.
The
findings
indicated
that
presence
Zr
Ti
metals
in
MOF-on-MOF
could
significantly
increase
separation
photogenerated
electron–hole
pairs
then
enhance
photocatalytic
performance.
present
study
not
only
provides
insights
into
on
other
but
also
develops
materials
coupling
reactions
organic
irradiation.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(3), P. 1073 - 1080
Published: March 1, 2024
Herein,
we
report
a
highly
regioselective
[4
+
2]-annulation
of
vinyl
sulfoxonium
ylides
with
ynoates
under
light-mediated
conditions.
The
reaction
proceeds
through
the
new
dienyl
ylide,
which
undergoes
photolysis
blue
light
irradiation
to
give
substituted
naphthalene
scaffolds.
method
presented
here
operates
at
room
temperature
and
does
not
require
addition
an
external
photosensitizer.
in
situ-generated
ylide
absorbs
acts
as
photosensitizer
for
formation
arenes.
synthetic
potential
these
benzannulations
was
further
illustrated
by
various
transformations
scale-up
reaction.
Moreover,
control
experiments
quantum
chemical
calculations
reveal
mechanistic
details
developed
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: April 29, 2022
The
radical
chemistry
of
ynamides
has
recently
drawn
the
attention
synthetic
organic
chemists
to
construction
various
N-heterocyclic
compounds.
Nevertheless,
ynamide-radical
remains
a
long-standing
challenge
for
due
its
high
reactivity,
undesirable
byproducts,
severe
inherent
regio-
and
chemoselective
problems.
Importantly,
ynamide
C(sp)-N
bond
fission
an
unsolved
challenge.
In
this
paper,
we
observe
Photoinduced
trigger
fission,
structural
reshuffling
functionalization
2-alkynyl-ynamides
prepare
synthetically
inaccessible/challenging
chalcogen-substituted
indole
derivatives
with
excellent
step/atom
economy.
key
breakthroughs
work
includes,
cleavage,
divergent
precursors,
broad
scope,
easy
handle,
larger-scale
reactions,
generation
multiple
bonds
(N-C(sp2),
C(sp2)-C(sp2),
C(sp2)-SO2R/C-SR,
C-I/C-Se/C-H)
in
few
minutes
without
photocatalysts,
metals,
oxidants,
additives.
Control
experiments
13C-labeling
supporting
conclusion
that
sulfone
radicals
contribute
processes
via
pathway.
Green Synthesis and Catalysis,
Journal Year:
2023,
Volume and Issue:
5(1), P. 1 - 13
Published: Aug. 15, 2023
Spirooxindole
is
a
compound
with
unique
framework
and
broad
bioactivities
in
medicine.
In
this
study,
we
have
reviewed
various
approaches
or
methods
synthesizing
spirooxindole
derivatives
focused
on
green
synthesis.
Synthesis
of
spirooxindoles
mainly
carried
out
through
multicomponent
reactions
combined
such
as
the
use
heterogeneous
catalysts
(nano-sized,
magnetic,
metal-complex,
metal-organic
catalysts),
deep
eutectic
solvent,
solvent-free
reactions,
catalyst-free
well
ultrasonic
microwaves
irradiation.
The
method
addition
to
obtaining
high
yields,
it
also
offers
reductions
hazardous
chemicals,
energy
use,
purification
processes,
waste
generation.
As
result,
synthesis
are
more
environmentally
friendly.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2365 - 2370
Published: March 20, 2024
A
green
visible-light-promoted
and
electron
donor–acceptor
(EDA)
complex-driven
synthetic
strategy
for
the
construction
of
value-added
naphtho[1′,2′:4,5]imidazo[1,2-a]pyridines
from
2-arylimidazo[1,2-a]pyridines
with
Z-α-bromocinnamaldehydes
has
been
accomplished
under
photocatalyst-
transition-metal-free
conditions.
This
efficient
annulation
approach
provides
a
new
straightforward
pathway
annulative
π-extension
imidazo[1,2-a]pyridine-based
aromatics.
Moreover,
sustainable
methodology
exhibits
simple
operation,
wide
range
substrates,
benign
conditions,
good
functional
group
compatibility.
