Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(18), P. 2311 - 2316
Published: May 13, 2023
Comprehensive
Summary
A
transition‐metal‐free
one‐pot
direct
synthesis
of
tetrathiophosphates
(R
1
S)
2
P(S)SR
from
white
phosphorus
(P
4
),
through
intermediate
sodium
alkyltetrathiophosphates
P(S)SNa,
is
presented.
In
the
presence
NaSH,
various
disulfides
such
as
diaryl
disulfidbges
and
dialkyl
are
easily
coupled
with
P
to
give
P(S)SNa
in
almost
quantitative
yield,
which
react
alkyl
halides
one
pot
generate
.
Furthermore,
S
‐(2‐cyanoethyl)‐substituted
P(S)SCH
CH
CN
successfully
designed
a
kind
tetrathiophosphorylation
reagent
iodonium
salts
involving
deprotection‐dealkylation
process.
Expert Opinion on Drug Discovery,
Journal Year:
2022,
Volume and Issue:
17(5), P. 501 - 512
Published: Feb. 23, 2022
Sulfur-containing
functional
groups
are
privileged
motifs
that
occur
in
various
pharmacologically
effective
substances
and
several
natural
products.
Various
functionalities
found
with
a
sulfur
atom
at
diverse
oxidation
states,
as
illustrated
by
thioether,
sulfoxide,
sulfone,
sulfonamide,
sulfamate,
sulfamide
functions.
They
valuable
scaffolds
the
field
of
medicinal
chemistry
part
large
array
approved
drugs
clinical
candidates.Herein,
authors
review
current
research
on
development
organosulfur-based
drug
discovery.
This
article
also
covers
details
their
roles
new
lead
compounds
reported
literature
over
past
five
years
2017-2021.Given
its
prominent
role
importance
discovery,
has
attracted
continuing
interest
been
used
design
demonstrate
variety
biological
pharmacological
feature
activities.
Overall,
sulfur's
continues
to
grow.
However,
many
remain
underused
small-molecule
discovery
deserve
special
attention
armamentarium
for
treating
diseases.
Research
efforts
still
required
synthetic
methodology
direct
access
these
functions
late-stage
functionalization.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(24), P. 14038 - 14083
Published: Nov. 2, 2023
Incorporating
sulfur
(S)
atoms
into
polymer
main
chains
endows
these
materials
with
many
attractive
features,
including
a
high
refractive
index,
mechanical
properties,
electrochemical
and
adhesive
ability
to
heavy
metal
ions.
The
copolymerization
involving
S-containing
monomers
constitutes
facile
method
for
effectively
constructing
polymers
diverse
structures,
readily
tunable
sequences,
topological
structures.
In
this
review,
we
describe
the
recent
advances
in
synthesis
of
via
or
multicomponent
polymerization
techniques
concerning
variety
monomers,
such
as
dithiols,
carbon
disulfide,
carbonyl
sulfide,
cyclic
thioanhydrides,
episulfides
elemental
(S8).
Particularly,
significant
focus
is
paid
precise
control
main-chain
sequence,
stereochemistry,
structure
achieving
high-value
applications.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(48), P. 8895 - 8900
Published: Nov. 28, 2022
Herein,
we
report
a
facile,
efficient,
and
practical
protocol
that
enables
the
preparation
of
aryl
xanthates
dithiocarbamates
from
functionalized
dibenzothiophenium
salts
via
photoactivated
electron
donor-acceptor
complex.
This
mild,
metal-free
method
is
operationally
simple
has
broad
substrate
scope
potential
utility
for
late-stage
functionalization
natural
products
pharmaceuticals.
Finally,
this
also
redefined
reaction
pathway
Leuckart
thiophenol
reaction.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(16)
Published: Feb. 10, 2023
We
herein
report
a
method
that
enables
the
generation
of
glycosyl
radicals
under
highly
acidic
conditions.
Key
to
success
is
design
and
use
sulfinates
as
radical
precursors,
which
are
bench-stable
solids
can
be
readily
prepared
from
commercial
starting
materials.
This
development
allows
installation
units
onto
pyridine
rings
directly
by
Minisci
reaction.
further
demonstrate
utility
this
in
late-stage
modification
complex
drug
molecules,
including
anticancer
agent
camptothecin.
Experimental
studies
provide
insight
into
reaction
mechanism.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(16)
Published: Feb. 27, 2023
Although
the
direct
conversion
of
gaseous
acetylene
into
value-added
liquid
commodity
chemicals
is
becoming
increasingly
attractive,
majority
established
methodologies
are
focused
on
cross-coupling,
hydro-functionalization,
and
polymerization.
Herein,
we
describe
a
1,2-difunctionalization
method
that
inserts
directly
readily
available
bifunctional
reagents.
This
provides
access
to
diverse
C2-linked
1,2-bis-heteroatom
products
in
high
regio-
stereoselectivity
along
with
opening
up
previously
unexplored
synthetic
directions.
In
addition,
demonstrate
this
method's
potential
by
converting
obtained
functionalized
molecules
chiral
sulfoxide-containing
bidentate
ligands.
Using
combination
experimental
theoretical
methods,
mechanism
for
insertion
reaction
was
investigated.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(20), P. 5171 - 5179
Published: Jan. 1, 2023
We
report
a
cross-electrophile
coupling
of
aryl
thiols
with
bromides
via
C–S
bond
activation
instead
S–H
cleavage.
The
reaction
proceeded
effectively
in
the
presence
nickel
catalyst,
magnesium,
and
lithium
chloride
to
afford
various
biaryls
moderate
good
yields.
