Natural Product Research,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 13
Published: Nov. 27, 2023
There
has
been
a
growing
emphasis
on
developing
extraction
methods
that
are
not
only
efficient
but
also
environmentally
friendly
and
sustainable.
One
promising
avenue
is
the
exploration
of
deep
eutectic
solvents
(DESs)
as
neoteric
media.
This
study
aims
to
investigate
potential
DESs
media
for
phenolics-rich
flower
clove
extracts.
Two
were
synthesised
by
mixing
choline
chloride
with
glycerol
lactic
acid
at
molar
ratio
1:2.
The
thermal
profiles
mixture
analysed
using
differential
scanning
calorimetry,
viscosity
density
measured
different
temperatures.
phenolic
compounds
quantitatively
characterised
all
extractants
high-performance
liquid
chromatography.
total
content
antioxidant
activities
extracts
determined.
results
showed
significantly
improved
from
clove,
especially
case
compounds,
considerably
enhanced
activity
use
offers
green,
method
extracting
value-added
products
natural
sources.
Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
102, P. 106761 - 106761
Published: Jan. 1, 2024
In
China,
Jiang
Fructus
aurantii
(JFA)
has
attracted
increasing
interest
as
a
famous
traditional
herbal
medicine
and
valuable
economic
food
for
its
medicinal
industrial
properties.
the
current
work,
contrasted
with
conventional
extraction
techniques,
natural
flavonoids
from
JFA
(naringin
neohesperidin)
were
extracted
remarkable
effectiveness
utilizing
sustainable
deep
eutectic
solvents
combined
ultrasonic-assisted
(DESs-UAE)
protocol.
The
optimal
capacity
can
be
achieved
by
mixing
30
%
water
molar
ratio
of
1:3
choline
chloride
ethylene
glycol,
opposed
to
classical
95
ethanol,
methanol,
water.
Moreover,
DESs-UAE
programs
also
systematically
optimized
employing
Box-Behnken
design
(BBD)
trials,
eventual
findings
suggested
that
best
parameters
27
content
in
DES,
16
mL/g
liquid–solid
ratio,
72
min
time,
62
°C
temperature,
along
corresponding
greatest
contents
NAR
(48.18
mg/g)
NEO
(34.50
mg/g),
respectively.
Notably,
comparison
pre-optimization
data,
DES
efficiency
is
markedly
higher.
Thereafter,
characterization
before
after
extraction,
well
differences
between
four
solvent
extracts,
compared
using
FT-IR
analyses.
Furthermore,
SEM
results
penetration
erosion
abilities
plant
cell
wall
DES-1
stronger
than
those
other
three
solvents,
thus
allowing
more
release
flavonoid
compounds.
conclusion,
present
research
develops
straightforward,
sustainable,
exceedingly
efficient
approach
bioactive
JFA,
which
potential
facilitate
acquisition
active
ingredients
TCM.
Green Chemical Engineering,
Journal Year:
2024,
Volume and Issue:
6(1), P. 36 - 53
Published: June 1, 2024
This
article
presents
a
comprehensive
overview
of
recent
advancements
in
natural
product
extraction,
focusing
on
the
evolution
from
deep
eutectic
solvents
(DESs)
to
systems
(DESys)
for
extraction.
DESs,
known
their
environmentally
friendly
properties,
have
become
crucial
extracting
various
products
plants,
including
micromolecules,
lignin,
and
polysaccharides.
Research
into
extraction
mechanism
reveals
that
target
compounds
typically
form
hydrogen
bonds
with
effectively
becoming
part
solvent
system.
insight
has
led
development
DESys
method,
where
bond
acceptors
(HBAs)
donors
(HBDs)
are
directly
mixed
sample
system
containing
compounds.
The
shift
DES-based
DESys-based
introduces
innovative
approaches
integral
system,
allowing
one-step
dissolution
methodology
eliminates
need
pre-prepared
simplifying
processes
enhancing
efficiency.
Additionally,
strategies
DESs
recycling
reuse
contribute
sustainability
efforts,
offering
cost-effective
solutions.
expanding
applications
cosmetics,
food,
industry,
environmental
fields
highlight
promising
potential.
By
delineating
transition
products,
this
review
offers
valuable
insights
advancing
practice
green
chemical
engineering.
Many
natural
products
(NPs)
exhibit
strong
antioxidant
activity,
making
them
valuable
for
various
applications.
In
this
context,
the
emergence
of
deep
eutectic
solvents
(DESs)
is
expected
to
help
address
growing
demand
innovative,
efficient,
and
more
sustainable
methods
NPs
extraction.
DESs
are
designer
that
provide
higher
yields
enhance
activity
extracted
phytochemicals
compared
with
conventional
volatile
organic
solvents.
Antioxidant
naturally
occurring
molecules
can
also
form
DESs,
either
as
hydrogen
bond
donors
(HBD)
or
acceptors
(HBA),
creating
DES
(NADES)
inherent
activity.
Thus,
containing
exert
synergistic
effects,
entire
system
a
promising
active
ingredient
food
industry
The
synergy
arises
from
enhanced
solubilization
stabilization
in
through
bonding,
ionic
interactions,
van
der
Waals
forces.
Collectively,
enable
effectively
neutralize
oxidants
(such
ROS
free
radicals)
regulate
their
reactions
other
molecules,
achieving
up
3-fold
increase
extracts
regular
vitro.
This
Account
overviews
wide
range
resources
using
DESs.
activities
HBA,
HBD,
along
advantageous
coupling
extracts,
thoroughly
discussed.
Finally,
we
envisage
future
directions
potential
applications
harnessing
collective
guide
advances
chemistry.
Foods,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1916 - 1916
Published: May 8, 2023
Melissa
officinalis
L.
is
a
medicinal
plant
used
worldwide
for
ethno-medical
purposes.
Today,
it
grown
everywhere;
while
known
to
originate
from
Southern
Europe,
now
found
around
the
world,
North
America
New
Zealand.
The
biological
properties
of
this
are
mainly
related
its
high
content
phytochemical
(bioactive)
compounds,
such
as
flavonoids,
polyphenolic
aldehydes,
glycosides
and
terpenes,
among
many
other
groups
substances.
Among
main
activities
associated
with
antimicrobial
activity
(against
fungi
bacteria),
antispasmodic,
antioxidant
insomnia
properties.
still
by
society
(as
natural
medicine)
alleviate
illnesses
symptoms.
Therefore,
in
perspective,
we
provide
an
update
on
profiling
analysis
plant,
well
relationships
specific
pharmacological
effects
phytochemicals.
Currently,
organic
solvents,
ethanol
reveals
highest
effectiveness
solvent
extraction
precious
components
(mainly
rosmarinic
acid).
Additionally,
our
attention
devoted
current
developments
fractionation
phytochemicals
M.
officinalis,
highlighting
ongoing
progress
strategies
that
research
community
has
employed.
Finally,
after
analyzing
literature,
suggest
potential
perspectives
field
sustainable
purification
present
plant.
For
instance,
some
gaps
concern
application
cavitation-assisted
processes,
which
can
effectively
enhance
mass
transfer
reducing
particle
size
extracted
material
situ.
Meanwhile,
membrane-assisted
processes
could
be
useful
obtained
extracts.
On
hand,
further
studies
should
include
ionic
liquids
deep
eutectic
solvents
(DES),
including
DESs
origin
(NADES)
hydrophobic
(hDES),
or
fractionating
along
new
possibilities
effective
formed
situ,
assisted
mechanical
mixing
(mechanochemistry-based
approach).
