Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
Abstract
Albeit
mechanochemistry
is
a
novel
promising
technology
that
gives
access
to
reactivity
under
solvent‐free
conditions,
heating
such
reactions
sometimes
compulsory
obtain
satisfactory
results
in
terms
of
conversion,
selectivity
and/or
yield.
In
this
work,
we
developed
approach
using
dye
absorbs
NIR
photons
and
release
the
energy
as
heat.
Hence,
de
novo
milling
jars
epoxy
resin
doped
with
were
thus
produced
reactors
would
produce
heat
upon
irradiation
at
850
nm.
Temperature
profiles
recorded,
depending
on
irradiance,
charge
resin,
frequency,
showing
an
excellent
control
temperature.
The
usefulness
jar
was
then
demonstrated
mechanochemical
are
known
require
yield
desired
product,
namely
Diels–Alder
high
activation
energies
newly
rearrangement
sydnone
into
corresponding
1,3,4‐oxadiazolin‐2‐one.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(10), P. 5890 - 5899
Published: Jan. 1, 2024
A
novel
approach
utilizing
the
polymer-assisted
grinding
(POLAG)
technique
to
facilitate
regioselective
oxidative
Heck
coupling
of
aryl
boronic
acids
with
electronically
unbiased
olefins
under
solvent-free
conditions
was
presented.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(13), P. 2620 - 2629
Published: Jan. 1, 2024
Mechanochemical
reactions
achieved
by
processes
such
as
milling
and
grinding
are
promising
alternatives
to
traditional
solution-based
chemistry.
This
approach
not
only
eliminates
the
need
for
large
amounts
of
solvents,
thereby
reducing
waste
generation,
but
also
finds
applications
in
chemical
materials
synthesis.
The
focus
this
study
is
on
synthesis
quinazolinone
derivatives
ball
milling,
particular
evodiamine
rutaecarpine
analogues.
These
compounds
interest
due
their
diverse
bioactivities,
including
potential
anticancer
properties.
examines
carried
out
under
conditions,
emphasizing
efficiency
terms
shorter
reaction
times
reduced
environmental
impact
compared
conventional
methods.
analogues
resulted
yields
63-78%
22-61%,
respectively.
In
addition,
these
were
tested
cytotoxic
activity,
exhibited
an
IC
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(31)
Published: June 25, 2024
Abstract
Herein
we
report
our
observations
from
the
study
of
classical
Robinson
annulation
reaction
under
solvent‐free
mechanochemical
activation
by
means
high‐speed
ball
milling.
In
particular,
enantioselective
synthesis
Wieland‐Miescher
ketone
was
used
as
model
reaction.
(
S
)‐Proline
employed
chiral
organocatalyst,
either
alone
or
in
presence
additives
order
to
determine
their
influence
on
reaction's
speed
and
stereoselectivity.
Most
interesting,
among
that
were
examined,
four
solvate
ionic
liquids
SIL
)
afforded
desired
product
with
significantly
improved
enantioselectivity
relative
mechanochemically‐activated
catalyzed
)‐proline
alone.
Furthermore,
required
time
reduced
3
days
90
min.
The
potential
other
proline‐type
organocatalysts
explored
this
ball‐milling
process.
Initial
attempts
increase
scope
afford
related
products
unsuccessful.
HPLC‐MS
experiments
carried
out
detect
some
species
intervene
mechanism
)‐proline‐catalyzed
cyclization
involving
2‐methyl‐1,3‐cyclohexanedione
methyl
vinyl
ketone.
RSC Mechanochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Ball-milling
allowed
the
efficient
preparation
of
ruthenium
complexes
with
photoredox
properties.
With
a
transparent
and
chemically
resistant
milling
jar
in
epoxy
resin,
photoreductive
dehalogenation
was
realized
efficiently
solventless
manner.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 16, 2024
In
the
present
work,
we
report
development
of
a
rapid,
efficient,
and
solvent-free
procedure
for
N-methylation
secondary
amines
under
mechanochemical
conditions.
After
optimization
milling
parameters,
vibrational
ball
mill
was
used
to
synthesize
26
tertiary
N-methylated
amine
derivatives
in
short
time
20
min
(30
Hz
frequency)
high
yields
ranging
from
78
95%.
An
exception
compounds
having
hydroxyl
group
their
structure,
which
decrease
reaction
efficiency
observed.
During
our
research,
investigated
alternate
selectivity
occurring
able
form
ring
closure
products
that
are
3,4-dihydro-2H-1,3-benzoxazine
instead
products.
The
liquid-assisted
grinding
technique
has
been
applied
using
formalin
as
methylating
agent
sodium
triacetoxyborohydride
reducing
reductive
amination
reaction.
